Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie

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Identification of 5-hydroxytryptamine1A receptor agents using a composite pharmacophore analysis and chemical database screening
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - Tập 343 - Trang 109-116 - 1991
Andrew J. Sleight, Stephen J. Peroutka
A composite pharmacophore analysis and computer-assisted chemical database screening were used to identify a previously unrecognized class of 5-hydroxytryptamine1A (5-HT1A) receptor active agents. An analysis of published data led to the identification of 20 different chemical structures which share nanomolar affinity for the 5-HT1A receptor. From a composite pharmacophore analysis of all 20 poten... hiện toàn bộ
Der Einflu� partieller Adrenalektomien auf Wasserdiurese und endogene Kreatinin-Clearance bei einseitig nephrektomierten Ratten
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - - 1959
Georg Peters
Surprises from a cardiac 5-HT4 TG mouse: spontaneous atrial arrhythmias by endogenous 5-HT of atrial origin? Different mechanism of arrhythmias through 5-HT4 receptors and β-adrenoceptors?
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - Tập 386 Số 5 - Trang 353-356 - 2013
Alberto J. Kaumann
Increasing effect of ethanol on 5-HT3 receptor-mediated 14C-guanidinium influx in N1E-115 neuroblastoma cells
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - Tập 352 Số 2 - Trang 149-156 - 1995
Barann, Martin, Ruppert, Karin, Göthert, Manfred, Bönisch, Heinz
NlE-115 mouse neuroblastoma cells were used to study the influence of ethanol on the 5-HT- and veratridine-induced influx of 14C-guanidinium via the 5-HT3 receptor channel and the fast sodium channel, respectively. Ethanol (10–100 mM) concentration-dependently increased the 5-HT-induced 14C-guanidinium influx, leaving the basal and veratridine (100 μM)-induced influx unaffected. The increasing eff... hiện toàn bộ
Differential effects of methylxanthines on local cerebral blood flow and glucose utilization in the conscious rat
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - Tập 333 - Trang 172-177 - 1986
J. J. Grome, V. Stefanovich
The aim of this study was to test the effects of the three “classical” methylxanthines, theophylline, caffeine and theobromine, on local cerebral blood flow and glucose utilization. Equimolar doses (1.6 μmol/kg/min i.v.) of theophylline and caffeine produced increases in local cerebral glucose utilization and decreases in local cerebral blood flow. These compounds, therefore, re-set the ratio of c... hiện toàn bộ
Ueber das Secale cornutum
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - Tập 4 - Trang 387-408 - 1875
Zweifel
Does anticholinergic medication have a role in treating men with overactive bladder and benign prostatic hyperplasia?
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - Tập 377 - Trang 491-501 - 2008
Kyu-Sung Lee, Hye Won Lee, Deok Hyun Han
This review discusses the available evidence concerning the use of anticholinergic drugs, alone or in combination with α-adrenoceptor antagonists, in men with lower urinary tract symptoms due to benign prostatic hyperplasia, benign prostatic enlargement, or benign prostatic obstruction and concomitant overactive bladder syndrome. We emphasize the safety and efficacy of anticholinergic agents in tr... hiện toàn bộ
Genistein: a promising modulator of apoptosis and survival signaling in cancer
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - Tập 396 - Trang 2893-2910 - 2023
Hemant Joshi, Dhruv Sanjay Gupta, Nosheen Kamruddin Abjani, Ginpreet Kaur, Chakrabhavi Dhananjaya Mohan, Jagjit Kaur, Diwakar Aggarwal, Isha Rani, Seema Ramniwas, Hadi Sajid Abdulabbas, Madhu Gupta, Hardeep Singh Tuli
Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-expanding spectrum of pharmacological benefits. In addition to health benefits such as improved bone health and reduced postmenopausal complications owing to its phytoestrogen properties, it has been widely evaluated for its anti-cancer potential. Several studies have established the potential for its usag... hiện toàn bộ
Die Funktion der schleimartigen Substanzen in den galenischen Präparaten aus Digitalisblättern
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - Tập 163 - Trang 353-365 - 1932
R. A. Hoekstra, H. E. J. ten Kleij
Die schleimartigen Substanzen, welche sich in den galenischen Produkten von Digitalis purpurea finden, hemmen die Kumulation der Glykoside aus diesem Blatte. Es ist wahrscheinlich, daß auch die Blätter von Digitalis lanata ähnlich wirkende schleimartige Substanzen enthalten. Unter Einfluß dieser Schleimstoffe läßt sich die Digitoxinvergiftung des isolierten Froschherzens größtenteils rückgängig ma... hiện toàn bộ
Die chemische Standardisierung des Insulins
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - Tập 128 - Trang 93-96 - 1928
W. Fornet
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