Zur Wirkung von Lithiumcarmin und Lithiumcarbonat auf die Embryonalentwicklung der Maus
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie - Tập 270 - Trang 56-64 - 1971
Tóm tắt
Carmine in a 1% lithium carbonate solution, forms the acid vital dye lithium carmine. The present paper deals with the question whether the embryotoxic and teratogenic effects resulting from the administration of lithium carmine to mice are due to the carmine itself or to the lithium ions. Mice of the NMRI/Han strain were injected i. p. on the 8th day of pregnancy with 100 mg/kg carmine using either a 2.5% or a 4.0% lithium carmine solution. A third group of mice received 40 mg/kg lithium carbonate in 1% solution, corresponding to the dose of lithium given by injecting the 2.5% solution of lithium carmine. Control animals were injected with 0.2 ml of saline. The following results were obtained:
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