NanoBiotechnology

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Quantitative detection of engineered nanoparticles in tissues and organs: An investigation of efficacy and linear dynamic ranges using ICP-AES
NanoBiotechnology - Tập 3 - Trang 46-54 - 2007
H. C. Fischer, S. Fournier-Bidoz, W. C. W. Chan, K. S. Pang
The absence of effective non-isotopic quantification methods to determine in vivo nanoparticle kinetics and distribution is a key obstacle to the development of various biomedical nanotechnologies. This paper presents a novel adaptation of the established technology of Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) to a simple technique intended to address this obstacle. Applica...... hiện toàn bộ
Hệ thống vi mô cho phân tích quá trình truyền tín hiệu tế bào Dịch bởi AI
NanoBiotechnology - Tập 1 - Trang 277-278 - 2005
Alexander Ganser, Günter Roth, Karsten Köhler, Thomas André, Andreas Heeren, Wolfgang Henschel, Dieter Kern, Karl-Heinz Wiesmüller, Roland Brock
Phát triển thuốc và nghiên cứu sinh học tế bào đều phải đối mặt với sự phức tạp của mạng lưới truyền tín hiệu phân tử. Những mạng lưới này tích hợp thông tin từ các tác nhân kích thích khác nhau bên trong tế bào. Sự tiến bộ trong cả hai lĩnh vực này phần lớn sẽ phụ thuộc vào các kỹ thuật thực nghiệm phản ánh sự phức tạp của các mạng lưới tín hiệu tế bào. Việc thử nghiệm các tổ hợp, cho dù là của c...... hiện toàn bộ
Using microarrays and functional genomics to understand and target cancer
NanoBiotechnology - Tập 1 - Trang 255-256 - 2005
Torben F. Ørntoft
In our work microarrays are of importance for screening the whole genome to sort out important genes and also for constructing pathways systems for the understanding of the links between genes. Our studies demonstrate the potential clinical usefulness of microarrays for the classification of patients and for understanding cancer biology and identifying new drug targets.
Biocompatibility: Nanomaterials for cell- and tissue engineering
NanoBiotechnology - Tập 1 - Trang 308-309 - 2005
M. O. Riehle
The reaction of cells to varying topographic surfaces has been investigated ever since the beginnings of cell culture technology, as these features influence the cells principle behaviours such as adhesion, spreading, morphology, motility and proliferation. Interest in this aspect of cell biology was renewed when advanced fabrication methods became more widespread. This paper tries to briefly summ...... hiện toàn bộ
Toward nanoscopic medicine
NanoBiotechnology - Tập 1 - Trang 306-307 - 2005
Reiner Peters
The cell, as the origin of health and disease, can be considered as a network of nanoscopic elements embedded in a microcosm of membrane-bounded compartments. Among nanoscopic elements, protein complexes stand out, because they initiate and direct all cellular processes. Striking progress in proteomics, molecular imaging and fluorescence nanoscopy induce me to envision a “Nanoscopic Medicine”, i.e...... hiện toàn bộ
Nanoscale time-lapse AFM imaging in solution for DNA aggregation
NanoBiotechnology - Tập 1 - Trang 361-368 - 2005
Masato Saito, Yuzuru Takamura, Eiichi Tamiya
Revealing the behavior of biofunctional molecules (i.e., nucleic acids, nucleic acid binding reagents, enzymatic proteins, etc.) by monitoring them in solution is important for understanding the nanoscale dynamism of their interactions. Atomic force microscope (AFM) imaging with a dynamic force mode (DFM, i.e., tapping mode) in aqueous solution, has many advantages for the imaging of DNA morpholog...... hiện toàn bộ
Applications of carbon nanotubes for cancer research
NanoBiotechnology - Tập 1 - Trang 171-182 - 2005
Kasif Teker, Ranjani Sirdeshmukh, Kousik Sivakumar, Shoaxin Lu, Eric Wickstrom, Hsin-Neng Wang, Tuan Vo-Dinh, Balaji Panchapakesan
Carbon nanotubes have many unique properties such as high surface area, hollow cavities, and excellent mechanical and electrical properties. Interfacing carbon nanotubes with biological systems could lead to significant applications in various disease diagnoses. Significant progress in interfacing carbon nanotubes with biological materials has been made in key areas such as aqueous solubility, che...... hiện toàn bộ
Nanotechnology-Based Drug Delivery Systems
NanoBiotechnology - Tập 5 - Trang 17-33 - 2009
R. Ravichandran
In recent years, there has been a considerable interest in the development of novel drug delivery systems using nanotechnology. Nanoparticles represent a promising drug delivery system of controlled and targeted release. In this context, nanosuspensions will be effective in increasing the solubility and bioavailability of poorly soluble drugs. This review focuses on advantages, method of preparati...... hiện toàn bộ
Simultaneous detection of DNA-binding proteins using exo-Taq-based reaction
NanoBiotechnology - Tập 2 - Trang 117-121 - 2006
Takashi Fukumori, Hirotaka Miyachi, Kenji Yokoyama
The DNA-binding protein (DBP) has a wide range of roles such as those in DNA repair, recombination, and gene expression. Recently, a microarray-based method has been developed for the high-throughput analysis of DNA-protein interactions. However, to maximize the advantages of this method, the detection process should be improved so that the method can be applied to many proteins without the use of...... hiện toàn bộ
Gold functionalized nano-needles for angular protein movement visualization
NanoBiotechnology - Tập 1 - Trang 227-236 - 2005
A. R. Laine, D. Okuno, K. Tabata, Y. Okada, A. Tixier-Mita, H. Noji, H. Fujita
We have investigated and compared various methods of fabricating silicon nano-needles of 100–200 nm in diameter and 1–2 µm in length for visualization of motor protein movement. Owing to their thin and long geometry, the needles are ideal to amplify and visualize angular movement. To enable highly localized protein attachment, a well-defined attachment point at one end of the needles was prepared....... hiện toàn bộ
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