NanoBiotechnology
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Quantitative detection of engineered nanoparticles in tissues and organs: An investigation of efficacy and linear dynamic ranges using ICP-AES
NanoBiotechnology - Tập 3 - Trang 46-54 - 2007
The absence of effective non-isotopic quantification methods to determine in
vivo nanoparticle kinetics and distribution is a key obstacle to the development
of various biomedical nanotechnologies. This paper presents a novel adaptation
of the established technology of Inductively Coupled Plasma-Atomic Emission
Spectroscopy (ICP-AES) to a simple technique intended to address this obstacle.
Applica...
Hệ thống vi mô cho phân tích quá trình truyền tín hiệu tế bào Dịch bởi AI
NanoBiotechnology - Tập 1 - Trang 277-278 - 2005
Phát triển thuốc và nghiên cứu sinh học tế bào đều phải đối mặt với sự phức tạp
của mạng lưới truyền tín hiệu phân tử. Những mạng lưới này tích hợp thông tin từ
các tác nhân kích thích khác nhau bên trong tế bào. Sự tiến bộ trong cả hai lĩnh
vực này phần lớn sẽ phụ thuộc vào các kỹ thuật thực nghiệm phản ánh sự phức tạp
của các mạng lưới tín hiệu tế bào. Việc thử nghiệm các tổ hợp, cho dù là của c...
Using microarrays and functional genomics to understand and target cancer
NanoBiotechnology - Tập 1 - Trang 255-256 - 2005
In our work microarrays are of importance for screening the whole genome to sort
out important genes and also for constructing pathways systems for the
understanding of the links between genes. Our studies demonstrate the potential
clinical usefulness of microarrays for the classification of patients and for
understanding cancer biology and identifying new drug targets.
Toward nanoscopic medicine
NanoBiotechnology - Tập 1 - Trang 306-307 - 2005
The cell, as the origin of health and disease, can be considered as a network of
nanoscopic elements embedded in a microcosm of membrane-bounded compartments.
Among nanoscopic elements, protein complexes stand out, because they initiate
and direct all cellular processes. Striking progress in proteomics, molecular
imaging and fluorescence nanoscopy induce me to envision a “Nanoscopic
Medicine”, i.e...
Nanomechanics: Opening new frontiers in bio analyses and diagnostics
NanoBiotechnology - Tập 1 - Trang 289-289 - 2005
Micro-fabricated silicon cantilevers arrays offer a novel label-free approach
where ligand-receptor binding interactions occurring on the sensor generate
nanomechanical signals like bending or a change in mass that is optically
detected in-situ. We report the detection of multiple unlabelled biomolecules
simultaneously down to picomolar concentrations within minutes. Differential
measurements incl...
Localized articular cartilage defects
NanoBiotechnology - Tập 1 - Trang 43-63 - 2005
Current operative and non-operative treatments for articular cartilage (AC)
defect repair still fail to meet clinical expectations. These treatment options
and challenges will be reviewed from a clinical perspective. Various polymeric
and naturally occurring materials serving as scaffolds have shown promising
neocartilage formation, but few studies are able to draw good clinical
correlations. Whil...
Nanoscale time-lapse AFM imaging in solution for DNA aggregation
NanoBiotechnology - Tập 1 - Trang 361-368 - 2005
Revealing the behavior of biofunctional molecules (i.e., nucleic acids, nucleic
acid binding reagents, enzymatic proteins, etc.) by monitoring them in solution
is important for understanding the nanoscale dynamism of their interactions.
Atomic force microscope (AFM) imaging with a dynamic force mode (DFM, i.e.,
tapping mode) in aqueous solution, has many advantages for the imaging of DNA
morpholog...
Applications of carbon nanotubes for cancer research
NanoBiotechnology - Tập 1 - Trang 171-182 - 2005
Carbon nanotubes have many unique properties such as high surface area, hollow
cavities, and excellent mechanical and electrical properties. Interfacing carbon
nanotubes with biological systems could lead to significant applications in
various disease diagnoses. Significant progress in interfacing carbon nanotubes
with biological materials has been made in key areas such as aqueous solubility,
che...
Enhancement of Thermal Properties of Polyvinylpyrrolidone (PVP)-Coated Silver Nanoparticles by Using Plasmid DNA and their Localized Surface Plasmon Resonance (LSPR) Characteristics
NanoBiotechnology - Tập 4 - Trang 36-42 - 2009
In this paper, the enhancement of thermal properties of polymer-coated silver
nanoparticles by the addition of plasmid DNA is described. Nanoparticles of
noble metals such as gold and silver possess specific characteristics by virtue
of their quantum size effects. Therefore, noble metal nanoparticles are used for
chemical sensing and biosensing applications based on their localized surface
plasmon...
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