Short term (15 min) effects of activators of protein kinase A (PKA), PKC and PKG
on cardiac macroscopic (gj) and single channel (γj) gap junctional conductances
were studied in pairs of neonatal rat cardiomyocytes. Under dual whole-cell
voltage-clamp, PKC activation by 100 nM TPA increased gj by 16 ± 2% (mean ±
S.E.M, n=9), 1.5 mM of the PKG activator 8-bromo-cGMP (8Br-cGMP) decreased gj by
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