Molecular and Cellular Biochemistry
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Retraction Note: Baicalin augments the differentiation of osteoblasts via enhancement of microRNA-217
Molecular and Cellular Biochemistry - - 2024
Cytokines in exertion-induced skeletal muscle injury
Molecular and Cellular Biochemistry - Tập 179 - Trang 159-168 - 1998
Cytokines are a diverse family of intercellular signaling proteins that influence the movement, proliferation, differentiation, metabolism and membrane processes of target cells. Synthesis and release of cytokines from leukocytes in response to microbial stimuli are well known. This review, however, will present evidence that non-infectious stimuli can induce cytokine secretion from leukocytes and......
Effects of glyburide (glibenclamide) on myocardial function in Langendorff perfused rabbit heart and on myocardial contractility and slow calcium current in guinea-pig single myocytes
Molecular and Cellular Biochemistry - Tập 242 - Trang 81-87 - 2003
Glyburide, also known as glibenclamide, was shown to have positive inotropic effect in human and animal hearts. The objectives of the present study was to investigate the effects of glyburide on developed left ventricular pressure (DLVP), coronary flow (CF), and heart rate (HR), in isolated rabbit heart as well as its effects on myocardial contractility and L-type calcium current, iCa, in guinea p......
A novel loss-of-function mutation in TP53 in an endometrial cancer cell line and uterine papillary serous carcinoma model
Molecular and Cellular Biochemistry - Tập 297 - Trang 179-187 - 2006
The etiology of carcinoma of the uterine endometrium (ECa) is poorly understood. However, loss of apoptosis is one of the major factors that allow cancer cells to survive and progress. Hec50co, a poorly differentiated human ECa cell line, is widely used in the investigation of ECa. Previously, Hec50co xenograft tumor model in nude mice developed an advanced phenotype, similar to that of uterine pa......
Peroxidase-promoted oxidation and peroxidation of the serotonergic neurotoxin 5,7-dihydroxytryptamine
Molecular and Cellular Biochemistry - Tập 112 - Trang 35-44 - 1992
Spectral data provide the first evidence that lactoperoxidase, a model enzyme for most mammalian peroxidases, catalyzed the one-electron oxidation and/or peroxidation of 5,7-dihydroxytryptamine. This process correlates with the production of superoxide radicals as is evident from the observed inhibitory effect of superoxide dismutase on product formation. 5,7-Dihydroxytryptamine is a classical per......
Probucol modulates iron nitrilotriacetate (Fe-NTA)-dependent renal carcinogenesis and hyperproliferative response: diminution of oxidative stress
Molecular and Cellular Biochemistry - - 2007
Oxidative stress in the human heart is associated with changes in the antioxidative defense as shown after heart transplantation
Molecular and Cellular Biochemistry - Tập 204 - Trang 89-96 - 2000
The study was designed to demonstrate - for the first time in humans - that oxidative stress in the heart indicated by lipid peroxidation is associated with time--dependent changes in the enzymatic antioxidative defense. For this purpose, we analyzed the oxygen radical metabolism in 69 myocardial biopsies (taken between the fifth day and 6 years after transplantation) of 31 heart transplant recipi......
Nitric oxide up-regulates DNA-binding activity of nuclear factor-κB in macrophages stimulated with silica and inflammatory stimulants
Molecular and Cellular Biochemistry - - 2000
Nitric oxide (NO), a reactive nitrogen species, plays an important role in inflammatory lung damage. In the present study, we investigated the role of NO in DNA-binding activity of NF-κB in macrophages stimulated with silica or other inflammatory stimulants. Treatment of mouse macrophages (RAW264.7 cells) with a selective inhibitor of inducible nitric oxide synthase (iNOS), L-N6-(1-iminoethyl) lys......
Biphasic estrogen response on bovine adrenal medulla capillary endothelial cell adhesion, proliferation and tube formation
Molecular and Cellular Biochemistry - Tập 177 - Trang 97-105 - 1997
Abnormal angiogenesis underlies many pathological conditions and is critical for the growth and maintenance of various types of tumors, including hormone-dependent cancers. Since estrogens are potent carcinogens in humans and rodents, and are involved in regulating angiogenesis, this study was designed to examine the effect of estrogen on the behavior of an established bovine capillary endothelial......
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