Molecular and Cellular Biochemistry
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Retraction Note: Baicalin augments the differentiation of osteoblasts via enhancement of microRNA-217
Molecular and Cellular Biochemistry - - 2024
Cytokines in exertion-induced skeletal muscle injury
Molecular and Cellular Biochemistry - Tập 179 - Trang 159-168 - 1998
Cytokines are a diverse family of intercellular signaling proteins that influence the movement, proliferation, differentiation, metabolism and membrane processes of target cells. Synthesis and release of cytokines from leukocytes in response to microbial stimuli are well known. This review, however, will present evidence that non-infectious stimuli can induce cytokine secretion from leukocytes and......
Effects of glyburide (glibenclamide) on myocardial function in Langendorff perfused rabbit heart and on myocardial contractility and slow calcium current in guinea-pig single myocytes
Molecular and Cellular Biochemistry - Tập 242 - Trang 81-87 - 2003
Glyburide, also known as glibenclamide, was shown to have positive inotropic effect in human and animal hearts. The objectives of the present study was to investigate the effects of glyburide on developed left ventricular pressure (DLVP), coronary flow (CF), and heart rate (HR), in isolated rabbit heart as well as its effects on myocardial contractility and L-type calcium current, iCa, in guinea p......
A novel loss-of-function mutation in TP53 in an endometrial cancer cell line and uterine papillary serous carcinoma model
Molecular and Cellular Biochemistry - Tập 297 - Trang 179-187 - 2006
The etiology of carcinoma of the uterine endometrium (ECa) is poorly understood. However, loss of apoptosis is one of the major factors that allow cancer cells to survive and progress. Hec50co, a poorly differentiated human ECa cell line, is widely used in the investigation of ECa. Previously, Hec50co xenograft tumor model in nude mice developed an advanced phenotype, similar to that of uterine pa......
Peroxidase-promoted oxidation and peroxidation of the serotonergic neurotoxin 5,7-dihydroxytryptamine
Molecular and Cellular Biochemistry - Tập 112 - Trang 35-44 - 1992
Spectral data provide the first evidence that lactoperoxidase, a model enzyme for most mammalian peroxidases, catalyzed the one-electron oxidation and/or peroxidation of 5,7-dihydroxytryptamine. This process correlates with the production of superoxide radicals as is evident from the observed inhibitory effect of superoxide dismutase on product formation. 5,7-Dihydroxytryptamine is a classical per......
Correction of the biochemical defect in porphobilinogen deaminase deficient cells by non-viral gene delivery
Molecular and Cellular Biochemistry - Tập 250 - Trang 65-71 - 2003
Porphobilinogen deaminase (PBGD), the third enzyme in the biosynthesis of heme, is deficient in acute intermittent porphyria (AIP). AIP is a genetic disease characterized by neurovisceral and psychiatric disturbances. Despite a palliative treatment, it may still be lethal. An initial step towards gene therapy was recently taken by showing that PBGD could be expressed to correct the enzyme deficien......
Renoprotective effect of Erdosteine in rats against gentamicin nephrotoxicity: a comparison of 99mTc-DMSA uptake with biochemical studies
Molecular and Cellular Biochemistry - Tập 308 - Trang 35-42 - 2007
Erdosteine is a mucolytic agent having antioxidant properties through its active metabolites in acute injuries induced by pharmacological drugs. This study was designed to investigate the renoprotective potential of Erdosteine against gentamicin (GM)-induced renal dysfunction by using Technetium-99 m dimercaptosuccinic acid (Tc-99 m DMSA) uptake and scintigraphy in rats. For this purpose, male Wis......
Interleukin-8 stimulates progesterone production via the MEK pathway in ovarian theca cells
Molecular and Cellular Biochemistry - - 2012
Interleukin 8 (IL-8) is a chemoattractant associated with ovulation in the mammalian ovary. This chemokine is also involved in the recruitment and activation of neutrophils. Using bovine tissue, we examined the possible role of IL-8 in steroid production by theca cells of the large ovarian follicles. IL-8 promoted progesterone production and stimulated StAR expression in cultured theca cells. The ......
The effect of volume occupancy upon the thermodynamic activity of proteins: some biochemical consequences
Molecular and Cellular Biochemistry - Tập 55 Số 2 - Trang 119-140 - 1983
Influence of collagen gel substrata on certain biochemical activities of hepatocytes in primary culture
Molecular and Cellular Biochemistry - Tập 137 - Trang 127-133 - 1994
In order to study the influence of cell shape as modulated by the extracellular matrix on the cellular activity, hepatocytes isolated from liver were maintained on collagen I coated plastic substrata and collage I gel substrata and certain hepatocyte specific functions were investigated. The incorporation of3[H]-leucine into total proteins and albumin secreted by cells maintained on collagen gel w......
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