Molecular Imaging and Biology
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Quantitative Analysis of [18F]FMISO PET for Tumor Hypoxia: Correlation of Modeling Results with Immunohistochemistry
Molecular Imaging and Biology - Tập 19 - Trang 120-129 - 2016
Quantitative evaluation of tumor hypoxia based on H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole ([18F]FMISO) positron emission tomography (PET) can deliver important information for treatment planning in radiotherapy. However, the merits and limitations of different analysis methods in revealing the underlying physiological feature are not clear. This study aimed to assess these quantitativ......
Retrospective Brain Motion Correction in Glutamate Chemical Exchange Saturation Transfer (GluCEST) MRI
Molecular Imaging and Biology - Tập 21 - Trang 1064-1070 - 2019
To evaluate the feasibility of motion correction in glutamate chemical exchange saturation transfer (GluCEST) imaging, using a rat model of epileptic seizure. Epileptic seizure was induced in six male Wistar rats by intraperitoneal injection of kainic acid (KA). CEST data were obtained using a 7.0 T Bruker MRI scanner before and 3 h after KA injection. Retrospective motion correction was performed......
Non-invasive Standardised Uptake Value for Verification of the Use of Previously Validated Reference Region for [18F]Flortaucipir and [18F]Florbetapir Brain PET Studies
Molecular Imaging and Biology - Tập 23 - Trang 550-559 - 2021
The simplified reference tissue model (SRTM) is commonly applied for the quantification of brain positron emission tomography (PET) studies, particularly because it avoids arterial cannulation. SRTM requires a validated reference region which is obtained by baseline-blocking or displacement studies. Once a reference region is validated, the use should be verified for each new subject. This verific......
Chronic Cannabinoid Administration to Periadolescent Rats Modulates the Metabolic Response to Acute Cocaine in the Adult Brain
Molecular Imaging and Biology - Tập 13 - Trang 411-415 - 2010
To analyze brain metabolic response to acute cocaine in male and female Wistar rats with or without a history of cannabinoid exposure during periadolescence. The synthetic cannabinoid agonist CP 55,940 (CP) or its vehicle (VH), were administered to male and female rats during periadolescence. When these animals reached adulthood, saline and cocaine-induced changes in 2-deoxy-2-[18F]fluoro-D-glucos......
Quantification of Iron-Labeled Cells with Positive Contrast in Mouse Brains
Molecular Imaging and Biology - Tập 13 - Trang 672-678 - 2010
To quantify small amounts of iron-labeled cells in mouse brains with magnetic resonance imaging (MRI). Iron-labeled cells (from 500 to 7,500) were stereotaxically transplanted into the brain of living mice that were subsequently imaged with MRI at 4.7 T. We compared four quantitative methods: (1) T2 relaxometry, (2) T2* relaxometry, (3) the volume of the cloverleaf hypointense artifact generated o......
SUV of [68Ga]DOTATOC-PET/CT Predicts Response Probability of PRRT in Neuroendocrine Tumors
Molecular Imaging and Biology - Tập 17 Số 3 - Trang 313-318 - 2015
Immune Activation in Pregnant Rats Affects Brain Glucose Consumption, Anxiety-like Behaviour and Recognition Memory in their Male Offspring
Molecular Imaging and Biology - Tập 24 - Trang 740-749 - 2022
Prenatal infection during pregnancy is a risk factor for schizophrenia, as well as for other developmental psychiatric disorders, such as autism and bipolar disorder. Schizophrenia patients were reported to have altered brain metabolism and neuroinflammation. However, the link between prenatal infection, altered brain inflammation and metabolism, and schizophrenia remains unclear. In this project,......
The Value of In Vitro Binding as Predictor of In Vivo Results: A Case for [18F]FDDNP PET
Molecular Imaging and Biology - Tập 21 - Trang 25-34 - 2018
Caution is warranted when in vitro results of biomarkers labeled with tritium were perfunctorily used to criticize in vivo data and conclusions derived with the same tracers labeled with positron emitters and positron emission tomography (PET). This concept is illustrated herein with the PET utilization of [18F]FDDNP, a biomarker used for in vivo visualization of β-amyloid and tau protein neuroagg......
PET/CT in the Evaluation of Inflammatory Bowel Disease: Studies in Patients Before and After Treatment
Molecular Imaging and Biology - Tập 12 - Trang 85-88 - 2009
The purpose of this study was to evaluate the appropriate 2-deoxy-2-[18F]fluoro-d-glucose–positron emission tomography (FDG-PET) determination in patients with inflammatory bowel disease (IBD) before and after clinical improvement to see if this determination correlates with clinical activity. We performed PET–computed tomography (PET/CT) on five patients before and after successful medical therap......
Đánh giá hợp chất Technetium-99m gắn với thụ thể Neurokinin-1 nhằm chẩn đoán ung thư thần kinh nội tiết Dịch bởi AI
Molecular Imaging and Biology - Tập 22 - Trang 377-383 - 2019
Các khối u thần kinh nội tiết (NETs) có tỷ lệ sống sót 5 năm đáng kể khi được chẩn đoán ở giai đoạn sớm, nhưng lại có tính chất nguy hiểm hơn nếu chỉ được phát hiện sau khi di căn. Mặc dù nhiều phương pháp chẩn đoán hình ảnh như chụp cắt lớp vi tính (CT), chụp cắt lớp phát xạ positron, và chụp cộng hưởng từ có thể phát hiện được các khối u thần kinh nội tiết, nhưng tỷ lệ dương tính giả cao của chú......
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