Molecular Imaging and Biology

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2-deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography to Monitor Lung Inflammation and Therapeutic Response to Dexamethasone in a Murine Model of Acute Lung Injury
Molecular Imaging and Biology - Tập 25 - Trang 681-691 - 2023
Philip Z. Mannes, Clayton E. Barnes, Joseph D. Latoche, Kathryn E. Day, Jessie R. Nedrow, Janet S. Lee, Sina Tavakoli
To image inflammation and monitor therapeutic response to anti-inflammatory intervention using 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) in a preclinical model of acute lung injury (ALI). Mice were intratracheally administered lipopolysaccharide (LPS, 2.5 mg/kg) to induce ALI or phosphate-buffered saline as the vehicle control. A subset of mice in the ALI group ...... hiện toàn bộ
Immune Activation in Pregnant Rats Affects Brain Glucose Consumption, Anxiety-like Behaviour and Recognition Memory in their Male Offspring
Molecular Imaging and Biology - Tập 24 - Trang 740-749 - 2022
Cyprien G. J. Guerrin, Alexandre Shoji, Janine Doorduin, Erik F. J. de Vries
Prenatal infection during pregnancy is a risk factor for schizophrenia, as well as for other developmental psychiatric disorders, such as autism and bipolar disorder. Schizophrenia patients were reported to have altered brain metabolism and neuroinflammation. However, the link between prenatal infection, altered brain inflammation and metabolism, and schizophrenia remains unclear. In this project,...... hiện toàn bộ
Synchrotron Radiation X-Ray Phase Micro-computed Tomography as a New Method to Detect Iron Oxide Nanoparticles in the Brain
Molecular Imaging and Biology - - 2013
Marilena Marinescu, Max Langer, Anne Durand, Cécile Olivier, A. Chabrol, Hugo Rositi, Fabien Chauveau, Tae-Hee Cho, Norbert Nighoghossian, Yves Berthezène, Françoise Peyrin, Marlène Wiart
Synthesis, Radiolabeling, and In Vivo Pharmacokinetic Evaluation of the Amyloid Beta Radioligand [11C]AZD4694 in Nonhuman Primates
Molecular Imaging and Biology - Tập 16 - Trang 173-179 - 2013
Magnus Schou, Katarina Varnäs, Johan Sandell, Peter Johnström, Zsolt Cselenyi, Samuel Svensson, Ryuji Nakao, Nahid Amini, Linda Bergman, Anna Sumic, Balazs Gulyas, Eva Lindström-Böö, Christer Halldin, Lars Farde
[18F]AZD4694 (2-(2-18F-fluoro-6-(methylamino)-3-pyridyl)benzofuran-5-ol) is a radioligand suitable for imaging of amyloid beta deposits in the living human brain using positron emission tomography (PET). Here, we report the preparation and pharmacokinetic profile of its carbon-11 (t 1/2  = 20.4 min) labeled isotopolog [11C]AZD4694 and compar...... hiện toàn bộ
Cross-Modality Imaging of Murine Tumor Vasculature—a Feasibility Study
Molecular Imaging and Biology - Tập 23 Số 6 - Trang 874-893 - 2021
Lydia M. Zopf, Patrick Heimel, Stefan H. Geyer, Anoop Kavirayani, Susanne Reier, Vanessa Fröhlich, Alexander Stiglbauer-Tscholakoff, Zhe Chen, Lukas Nics, Jelena Zinnanti, Wolfgang Drexler, Markus Mitterhauser, Thomas H. Helbich, Wolfgang J. Weninger, Paul Slezak, Anna C. Obenauf, Katja Bühler, Andreas Walter
AbstractTumor vasculature and angiogenesis play a crucial role in tumor progression. Their visualization is therefore of utmost importance to the community. In this proof-of-principle study, we have established a novel cross-modality imaging (CMI) pipeline to characterize exactly the same murine tumors across scales and penetration depths, using orthotopic models o...... hiện toàn bộ
3D Amide Proton Transfer-Weighted Imaging for Grading Glioma and Correlating IDH Mutation Status: Added Value to 3D Pseudocontinuous Arterial Spin Labelling Perfusion
Molecular Imaging and Biology - - 2023
Huimin Hou, Weibo Chen, Yanzhao Diao, Yuhan Wang, Li Zhang, Liming Wang, Min Xu, Jinchao Yu, Tao Song, Yu Liu, Zhenguo Yuan
Molecular Ultrasound Imaging of Tissue Inflammation Using an Animal Model of Acute Kidney Injury
Molecular Imaging and Biology - Tập 17 - Trang 786-792 - 2015
Kenneth Hoyt, Jason M. Warram, Dezhi Wang, Sithira Ratnayaka, Amie Traylor, Anupam Agarwal
The objective of this study was to evaluate the use of molecular ultrasound (US) imaging for monitoring the early inflammatory effects following acute kidney injury. A population of rats underwent 30 min of renal ischemia (acute kidney injury, N = 6) or sham injury (N = 4) using established surgical methods. Animals were divided and molecular US imaging was performed during the bolus injection of ...... hiện toàn bộ
Death and Proliferation Time Course of Stem Cells Transplanted in the Myocardium
Molecular Imaging and Biology - Tập 11 - Trang 408-414 - 2009
Hui Qiao, Suleman Surti, Seok Rye Choi, Karthik Raju, Hualei Zhang, Datta E. Ponde, Hank F. Kung, Joel Karp, Rong Zhou
Noninvasive positron emission tomography (PET) imaging of reporter gene is combined with quantitative real-time polymerase reverse transcription (RT-PCR) method to study the time course of death and proliferation of stem cells transplanted in the myocardium. Male murine embryonic stem cells (ESCs) were stably transfected with a mutant version of herpes simplex virus type 1 thymidine kinase (HSV1-s...... hiện toàn bộ
Evaluation of the Temporal Window for Drug Delivery Following Ultrasound-Mediated Membrane Permeability Enhancement
Molecular Imaging and Biology - Tập 13 - Trang 239-249 - 2010
Anna Yudina, Matthieu Lepetit-Coiffé, Chrit T. W. Moonen
Ultrasound-induced cavitation facilitates cellular uptake of drugs via increased membrane permeability. Here, the purpose was to evaluate the duration of enhanced membrane permeability following ultrasound treatment in cell culture. Optical chromophores with fluorescence intensity increasing 100–1,000-fold upon intercalation with nucleic acids served as smart agents for reporting cellular uptake. ...... hiện toàn bộ
SimPET: a Preclinical PET Insert for Simultaneous PET/MR Imaging
Molecular Imaging and Biology - Tập 22 - Trang 1208-1217 - 2020
Jeong-Whan Son, Kyeong Yun Kim, Ji Yong Park, Kyuwan Kim, Yun-Sang Lee, Guen Bae Ko, Jae Sung Lee
SimPET/M7 system is a small-animal dedicated simultaneous positron emission tomography and magnetic resonance imaging (PET/MRI) scanner. The SimPET insert has been upgraded from its prototype with a focus on count rate performance and sensitivity. The M7 scanner is a 1-T permanent magnet-based compact MRI system without any cryogens. Here, we present performance evaluation results of SimPET along ...... hiện toàn bộ
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