Quantification of Iron-Labeled Cells with Positive Contrast in Mouse BrainsMolecular Imaging and Biology - Tập 13 - Trang 672-678 - 2010
Jean-Christophe Brisset, Monica Sigovan, Fabien Chauveau, Adrien Riou, Emilie Devillard, Virginie Desestret, Monique Touret, Serge Nataf, J. Honnorat, Emmanuelle Canet-Soulas, Norbert Nighoghossian, Yves Berthezene, Marlene Wiart
To quantify small amounts of iron-labeled cells in mouse brains with magnetic resonance imaging (MRI). Iron-labeled cells (from 500 to 7,500) were stereotaxically transplanted into the brain of living mice that were subsequently imaged with MRI at 4.7 T. We compared four quantitative methods: (1) T2 relaxometry, (2) T2* relaxometry, (3) the volume of the cloverleaf hypointense artifact generated o...... hiện toàn bộ
PET/CT in the Evaluation of Inflammatory Bowel Disease: Studies in Patients Before and After TreatmentMolecular Imaging and Biology - Tập 12 - Trang 85-88 - 2009
Bret J. Spier, Scott B. Perlman, Christine J. Jaskowiak, Mark Reichelderfer
The purpose of this study was to evaluate the appropriate 2-deoxy-2-[18F]fluoro-d-glucose–positron emission tomography (FDG-PET) determination in patients with inflammatory bowel disease (IBD) before and after clinical improvement to see if this determination correlates with clinical activity. We performed PET–computed tomography (PET/CT) on five patients before and after successful medical therap...... hiện toàn bộ
Optical Pretargeting of Tumor with Fluorescent MORF OligomersMolecular Imaging and Biology - Tập 9 - Trang 17-23 - 2006
Jiang He, Mary Rusckowski, Yi Wang, Shuping Dou, Xinrong Liu, Surong Zhang, Guozheng Liu, Donald J. Hnatowich
Pretargeting with radioactivity has significantly improved tumor to normal tissue radioactivity ratios over conventional antibody imaging in both animal studies and clinical trials. This laboratory is investigating DNA analogues such as phosphorodiamidate morpholinos (MORFs) for pretargeting using technetium-99m (99mTc) for detection. However, the unique properties of fluorescence activation and q...... hiện toàn bộ
Synchrotron Radiation X-Ray Phase Micro-computed Tomography as a New Method to Detect Iron Oxide Nanoparticles in the BrainMolecular Imaging and Biology - - 2013
Marilena Marinescu, Max Langer, Anne Durand, Cécile Olivier, A. Chabrol, Hugo Rositi, Fabien Chauveau, Tae-Hee Cho, Norbert Nighoghossian, Yves Berthezène, Françoise Peyrin, Marlène Wiart
A Pre-targeting Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based Contrast AgentsMolecular Imaging and Biology - Tập 13 - Trang 1196-1203 - 2010
Kohei Sano, Takashi Temma, Takashi Azuma, Ryusuke Nakai, Michiko Narazaki, Yuji Kuge, Hideo Saji
We aimed to establish a magnetic resonance imaging (MRI) protocol for the sensitive and specific imaging of functional molecules with a pre-targeting strategy utilizing the streptavidin–biotin interaction. Membrane type-1 matrix metalloproteinase (MT1-MMP) was selected as the target molecule. The biotinylated polyamidoamine dendrimer (PAMAM)-based contrast agent (Bt-PAMAM-DTPA(Gd)) was prepared, a...... hiện toàn bộ
In Vivo Imaging of miR-221 Biogenesis in Papillary Thyroid CarcinomaMolecular Imaging and Biology - Tập 11 - Trang 71-78 - 2008
Hyun Joo Kim, June-Key Chung, Do Won Hwang, Dong Soo Lee, Soonhag Kim
To investigate the overexpression of miR-221 in papillary thyroid carcinoma (PTC), we developed a Gaussia luciferase (Gluc) system regulated by miR-221. Quantities of primary or mature miR-221 in normal thyroid cells (HT-ori3) and in PTC (NPA, TPC-1) were measured by quantitative real-time polymerase chain reaction. Cytomegalovirus (CMV)/Gluc-3xPT_miR221, which included three perfect complementary...... hiện toàn bộ
TRIPODD: a Novel Fluorescence Imaging Platform for In Situ Quantification of Drug Distribution and Therapeutic ResponseMolecular Imaging and Biology - Tập 23 - Trang 650-664 - 2021
Nathan P. McMahon, Allison Solanki, Lei G. Wang, Antonio R. Montaño, Jocelyn A. Jones, Kimberley S. Samkoe, Kenneth M. Tichauer, Summer L. Gibbs
Personalized medicine has largely failed to produce curative therapies in advanced cancer patients. Evaluation of in situ drug target availability (DTA) concomitant with local protein expression is critical to an accurate assessment of therapeutic efficacy, but tools capable of both are currently lacking. We developed and optimized a fluorescence imaging platform termed TRIPODD (Therapeutic Respon...... hiện toàn bộ