Molecular Carcinogenesis
SCOPUS (1988-2023)SCIE-ISI
1098-2744
0899-1987
Mỹ
Cơ quản chủ quản: Wiley-Liss Inc. , WILEY
Lĩnh vực:
Cancer ResearchMolecular Biology
Các bài báo tiêu biểu
Molecular mechanisms of Nrf2‐mediated antioxidant responseAbstract Nrf2 is the key transcription factor regulating the antioxidant response. Nrf2 signaling is repressed by Keap1 at basal condition and induced by oxidative stress. Keap1 is recently identified as a Cullin 3‐dependent substrate adaptor protein. A two‐sites binding “hinge & latch” model vividly depicts how Keap1 can efficiently present Nrf2 as substrate fo... ...
Tập 48 Số 2 - Trang 91-104 - 2009
Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage
Tập 3 Số 4 - Trang 188-197 - 1990
Prostate cancer stem/progenitor cells: Identification, characterization, and implicationsAbstract Several solid tumors have now been shown to contain stem cell‐like cells called cancer stem cells (CSC). These cells, although generally rare, appear to be highly tumorigenic and may be the cells that drive tumor formation, maintain tumor homeostasis, and mediate tumor metastasis. In this Perspective , we first provide our insight ... ...
Tập 46 Số 1 - Trang 1-14 - 2007
DNA methyltransferase and demethylase in human prostate cancerAbstract Recent studies have shown that cytosine‐5 methylation at CpG islands in the regulatory sequence of a gene is one of the key mechanisms of inactivation. The enzymes responsible for CpG methylation are DNA methyltransferase (DNMT) 1, DNMT3a, and DNMT3b, and the enzyme responsible for demethylation is DNA demethylase (MBD2). Studies on methylation‐demethylatio... ...
Tập 33 Số 3 - Trang 163-171 - 2002
Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutaseAbstract Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation‐, but not chemically‐induced neoplastic tran... ...
Tập 6 Số 4 - Trang 238-242 - 1992
Peroxisome proliferator–activated receptor α in the human breast cancer cell lines MCF‐7 and MDA‐MB‐231Abstract Peroxisome proliferator–activated receptor (PPAR) α is a ligand‐activated transcription factor that has been linked with rodent hepatocarcinogenesis. It has been suggested that PPARα mRNA expression levels are an important determinant of rodent hepatic tumorigenicity. Previous work in rat mammary gland epithelial cells showed sign... ...
Tập 34 Số 4 - Trang 165-171 - 2002
The cyclooxygenase‐2‐mediated prostaglandin signaling is causally related to epithelial carcinogenesisAbstract Epidemiologic, pharmacologic, clinical, and experimental studies document the importance of prostaglandin (PG) signaling in cancer development, including non‐melanoma skin cancer lesions in humans and mice. First of all, enzymes involved in PG biosynthesis, such as cyclooxygenase (COX)‐2 and/or membrane prostaglandin E synthase (mPGES)‐1, were found to be o... ...
Tập 46 Số 8 - Trang 705-710 - 2007
Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her‐2/neu (erbB‐2) oncogene‐induced malignant transformationAbstract We designed our experiments to evaluate whether fatty acid synthase (FAS), a lipogenic enzyme linked to tumor virulence in population studies of human cancer, is necessary for the malignant transformation induced by Her‐2/neu (erbB‐2) oncogene, which is overexpressed not only in invasive breast cancer but also in premalignant atypical duct proliferations an... ...
Tập 41 Số 3 - Trang 164-178 - 2004
KAI1, A prostate metastasis suppressor: Prediction of solvated structure and interactions with binding partners; integrins, cadherins, and cell‐surface receptor proteins†Abstract The solution structure of the transmembrane‐4 superfamily protein KAI1, a recently identified prostate cancer metastasis suppressor gene that encodes a 267–amino acid protein, was modeled. The structure of this four‐helical transmembrane protein was developed by defining and modeling sections individually. A complete three‐dimensional structure for the solv... ...
Tập 32 Số 3 - Trang 139-153 - 2001
Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate SpecificityAbstract The vaccinia virus cDNA expression system was used to produce human cytochrome P450 IA2 in a hepatoma cell line that is devoid of significant basal levels of P450. The expressed enzyme yielded a reduced carbon monoxide‐bound difference spectrum with a λmax of 449 nm. Catalytic activities and mutagen activation ability of the human enzym... ...
Tập 2 Số 4 - Trang 192-198 - 1989