Molecular Carcinogenesis
SCOPUS (1988-2025)SCIE-ISI
1098-2744
0899-1987
Mỹ
Cơ quản chủ quản: Wiley-Liss Inc. , WILEY
Lĩnh vực:
Cancer ResearchMolecular Biology
Các bài báo tiêu biểu
Molecular mechanisms of Nrf2‐mediated antioxidant response
Tập 48 Số 2 - Trang 91-104 - 2009
AbstractNrf2 is the key transcription factor regulating the antioxidant
response. Nrf2 signaling is repressed by Keap1 at basal condition and induced by
oxidative stress. Keap1 is recently identified as a Cullin 3‐dependent substrate
adaptor protein. A two‐sites binding “hinge & latch” model vividly depicts how
Keap1 can efficiently present Nrf2 as substrate for ubiquitination. Oxidative
perturbat...
Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage
Tập 3 Số 4 - Trang 188-197 - 1990
Prostate cancer stem/progenitor cells: Identification, characterization, and implications
Tập 46 Số 1 - Trang 1-14 - 2007
AbstractSeveral solid tumors have now been shown to contain stem cell‐like cells
called cancer stem cells (CSC). These cells, although generally rare, appear to
be highly tumorigenic and may be the cells that drive tumor formation, maintain
tumor homeostasis, and mediate tumor metastasis. In this Perspective, we first
provide our insight on how a CSC should be defined. We then summarize our
curren...
DNA methyltransferase and demethylase in human prostate cancer
Tập 33 Số 3 - Trang 163-171 - 2002
AbstractRecent studies have shown that cytosine‐5 methylation at CpG islands in
the regulatory sequence of a gene is one of the key mechanisms of inactivation.
The enzymes responsible for CpG methylation are DNA methyltransferase (DNMT) 1,
DNMT3a, and DNMT3b, and the enzyme responsible for demethylation is DNA
demethylase (MBD2). Studies on methylation‐demethylation enzymes are lacking in
human pr...
Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase
Tập 6 Số 4 - Trang 238-242 - 1992
AbstractManganese superoxide dismutase (MnSOD) scavenges toxic superoxide
radicals produced in the mitochondria. Transfection of the human MnSOD gene into
mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was
properly transported into mitochondria. Overexpression of MnSOD protected cells
from radiation‐, but not chemically‐induced neoplastic transformation. This
finding demonstr...
Peroxisome proliferator–activated receptor α in the human breast cancer cell lines MCF‐7 and MDA‐MB‐231
Tập 34 Số 4 - Trang 165-171 - 2002
AbstractPeroxisome proliferator–activated receptor (PPAR) α is a
ligand‐activated transcription factor that has been linked with rodent
hepatocarcinogenesis. It has been suggested that PPARα mRNA expression levels
are an important determinant of rodent hepatic tumorigenicity. Previous work in
rat mammary gland epithelial cells showed significantly increased PPARα mRNA
expression in carcinomas, sug...
The cyclooxygenase‐2‐mediated prostaglandin signaling is causally related to epithelial carcinogenesis
Tập 46 Số 8 - Trang 705-710 - 2007
AbstractEpidemiologic, pharmacologic, clinical, and experimental studies
document the importance of prostaglandin (PG) signaling in cancer development,
including non‐melanoma skin cancer lesions in humans and mice. First of all,
enzymes involved in PG biosynthesis, such as cyclooxygenase (COX)‐2 and/or
membrane prostaglandin E synthase (mPGES)‐1, were found to be overexpressed in a
wide range of p...
Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her‐2/neu (erbB‐2) oncogene‐induced malignant transformation
Tập 41 Số 3 - Trang 164-178 - 2004
AbstractWe designed our experiments to evaluate whether fatty acid synthase
(FAS), a lipogenic enzyme linked to tumor virulence in population studies of
human cancer, is necessary for the malignant transformation induced by Her‐2/neu
(erbB‐2) oncogene, which is overexpressed not only in invasive breast cancer but
also in premalignant atypical duct proliferations and in ductal carcinoma in
situ of ...
KAI1, A prostate metastasis suppressor: Prediction of solvated structure and interactions with binding partners; integrins, cadherins, and cell‐surface receptor proteins†
Tập 32 Số 3 - Trang 139-153 - 2001
AbstractThe solution structure of the transmembrane‐4 superfamily protein KAI1,
a recently identified prostate cancer metastasis suppressor gene that encodes a
267–amino acid protein, was modeled. The structure of this four‐helical
transmembrane protein was developed by defining and modeling sections
individually. A complete three‐dimensional structure for the solvated protein
was developed by com...
Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity
Tập 2 Số 4 - Trang 192-198 - 1989
AbstractThe vaccinia virus cDNA expression system was used to produce human
cytochrome P450 IA2 in a hepatoma cell line that is devoid of significant basal
levels of P450. The expressed enzyme yielded a reduced carbon monoxide‐bound
difference spectrum with a λmax of 449 nm. Catalytic activities and mutagen
activation ability of the human enzyme were assessed and directly compared with
results obt...