Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase

Molecular Carcinogenesis - Tập 6 Số 4 - Trang 238-242 - 1992
Daret K. St. Clair1, X. Steven Wan2, Terry D. Oberley3, Kenneth E. Muse3, William H. St. Clair4
1Graduate Center for Toxicology, University of Kentucky, Lexington 40506-0054.
2Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky.
3Department of Pathology and VA Hospital, University of Wisconsin, Madison, Wisconsin
4Chandler Medical Center, University of Kentucky, Lexington, Kentucky

Tóm tắt

AbstractManganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation‐, but not chemically‐induced neoplastic transformation. This finding demonstrates that oxidative stress that occurs in the mitochondria plays an important role in the development of neoplastic transformation. © 1992 Wiley‐Liss, Inc.

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Molecular Carcinogenesis

Tập 6 Số 4

238-242

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