Molecular Carcinogenesis

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BRCA1 and acetyl‐CoA carboxylase: The metabolic syndrome of breast cancer
Molecular Carcinogenesis - Tập 47 Số 2 - Trang 157-163 - 2008
Joan Brunet, Alejandro Vázquez‐Martín, Rámón Colomer, Begoña Graña-Suárez, Begoña Martı́n-Castillo, Javier A. Menéndez
AbstractBreast cancer‐associated mutations affecting the highly‐conserved C‐terminal BRCT domains of the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1) fully disrupt the ability of BRCA1 to interact with acetyl co...... hiện toàn bộ
Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity
Molecular Carcinogenesis - Tập 2 Số 4 - Trang 192-198 - 1989
Toshifumi Aoyama, Frank J. Gonzalez, Harry V. Gelboin
AbstractThe vaccinia virus cDNA expression system was used to produce human cytochrome P450 IA2 in a hepatoma cell line that is devoid of significant basal levels of P450. The expressed enzyme yielded a reduced carbon monoxide‐bound difference spectrum with a λmax of 449 nm. Catalytic activities and mutagen activation ability of the human enzym...... hiện toàn bộ
Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage
Molecular Carcinogenesis - Tập 3 Số 4 - Trang 188-197 - 1990
Lars H. Breimer
Helicobacter pylori infection modulates the expression of miRNAs associated with DNA mismatch repair pathway
Molecular Carcinogenesis - Tập 56 Số 4 - Trang 1372-1379 - 2017
Juliana C. Santos, Mitsue Taukeuti Brianti, Victor R. de Almeida, Manoela Marques Ortega, Wolfgang Fischer, Rainer Haas, Ander Matheu, Marcelo Lima Ribeiro
Genetic and epigenetic inactivation of DNA mismatch repair (MMR) genes might lead to modifications in cancer‐related gene expression and cancer development. Recently, it has been shown that the infection by Helicobacter pylori, the major causative agent of gastric cancer, induces DNA damage and inhibits MMR DNA repair. Also, it has been re...... hiện toàn bộ
Diallyl trisulfide‐induced apoptosis in human cancer cells is linked to checkpoint kinase 1‐mediated mitotic arrest
Molecular Carcinogenesis - Tập 48 Số 11 - Trang 1018-1029 - 2009
Dong Xiao, Yan Zeng, Shivendra V. Singh
AbstractGrowth suppressive effect of diallyl trisulfide (DATS), a promising cancer chemopreventive constituent of garlic, against cultured human cancer cells correlates with checkpoint kinase 1 (Chk1)‐mediated mitotic arrest, but the fate of the cells arrested in mitosis remains elusive. Using LNCaP and HCT‐116 human cancer cells as a model, we now demonstrate that...... hiện toàn bộ
KAI1, A prostate metastasis suppressor: Prediction of solvated structure and interactions with binding partners; integrins, cadherins, and cell‐surface receptor proteins†
Molecular Carcinogenesis - Tập 32 Số 3 - Trang 139-153 - 2001
Rachelle J. Bienstock, J. Carl Barrett
AbstractThe solution structure of the transmembrane‐4 superfamily protein KAI1, a recently identified prostate cancer metastasis suppressor gene that encodes a 267–amino acid protein, was modeled. The structure of this four‐helical transmembrane protein was developed by defining and modeling sections individually. A complete three‐dimensional structure for the solv...... hiện toàn bộ
The suppression of MAD1 by AKT‐mediated phosphorylation activates MAD1 target genes transcription
Molecular Carcinogenesis - Tập 48 Số 11 - Trang 1048-1058 - 2009
Chao‐Kai Chou, Dung‐Fang Lee, Hailin Sun, Long‐Yuan Li, Chun‐Yi Lin, Wei‐Chien Huang, Jung-Mao Hsu, Hsu-Ping Kuo, Hirohito Yamaguchi, Ying‐Nai Wang, Mo Liu, Hsin-Yi Wu, Pao‐Chi Liao, Chia-Jui Yen, Mien‐Chie Hung
AbstractMAX dimerization protein 1 (MAD1) is a transcription suppressor that antagonizes MYC‐mediated transcription activation, and the inhibition mechanism occurs mainly through the competition of target genes' promoter MYC binding sites by MAD1. The promoter binding proteins switch between MYC and MAD1 affects cell proliferation and differentiation. However, litt...... hiện toàn bộ
Colorectal carcinoma development in inducible nitric oxide synthase‐deficient mice with dextran sulfate sodium‐induced ulcerative colitis
Molecular Carcinogenesis - Tập 46 Số 5 - Trang 341-353 - 2007
Darren N. Seril, Jie Liao, Guang‐Yu Yang
AbstractThe overproduction of reactive oxygen and nitrogen species (RONS) may play an important role in ulcerative colitis (UC)‐associated carcinogenesis. In order to study the role of nitric oxide (NO) in UC‐associated colorectal carcinogenesis, the development of colorectal carcinoma was studied using the DSS‐induced and iron‐enhanced model of chronic UC in induc...... hiện toàn bộ
Peroxisome proliferator–activated receptor α in the human breast cancer cell lines MCF‐7 and MDA‐MB‐231
Molecular Carcinogenesis - Tập 34 Số 4 - Trang 165-171 - 2002
K. M. Suchanek, Fiona J. May, J. A. Robinson, Won‐Jae Lee, N. A. Holman, Gregory R. Monteith, Sarah J. Roberts‐Thomson
AbstractPeroxisome proliferator–activated receptor (PPAR) α is a ligand‐activated transcription factor that has been linked with rodent hepatocarcinogenesis. It has been suggested that PPARα mRNA expression levels are an important determinant of rodent hepatic tumorigenicity. Previous work in rat mammary gland epithelial cells showed sign...... hiện toàn bộ
Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin‐induced apoptosis
Molecular Carcinogenesis - Tập 49 Số 4 - Trang 324-336 - 2010
Beena Joy, Rajeeve Sivadasan, Abraham T. Emilia, Mohan John, Praveen K. Sobhan, Mahendra Seervi, Santhoshkumar T.R.
AbstractXIAP is an important antiapoptotic protein capable of conferring resistance to cancer cells. Embelin, the small molecular inhibitor of XIAP, possesses wide spectrum of biological activities with strong inhibition of nuclear factor kappa B and downstream antiapoptotic genes. However, the mechanism of its cell death induction is not known. Our studies using c...... hiện toàn bộ
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