Molecular Carcinogenesis

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BRCA1 and acetyl‐CoA carboxylase: The metabolic syndrome of breast cancer
Molecular Carcinogenesis - Tập 47 Số 2 - Trang 157-163 - 2008
Joan Brunet, Alejandro Vázquez‐Martín, Rámón Colomer, Begoña Graña-Suárez, Begoña Martı́n-Castillo, Javier A. Menéndez
AbstractBreast cancer‐associated mutations affecting the highly‐conserved C‐terminal BRCT domains of the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1) fully disrupt the ability of BRCA1 to interact with acetyl co...... hiện toàn bộ
Helicobacter pylori infection modulates the expression of miRNAs associated with DNA mismatch repair pathway
Molecular Carcinogenesis - Tập 56 Số 4 - Trang 1372-1379 - 2017
Juliana C. Santos, Mitsue Taukeuti Brianti, Victor R. de Almeida, Manoela Marques Ortega, Wolfgang Fischer, Rainer Haas, Ander Matheu, Marcelo Lima Ribeiro
Genetic and epigenetic inactivation of DNA mismatch repair (MMR) genes might lead to modifications in cancer‐related gene expression and cancer development. Recently, it has been shown that the infection by Helicobacter pylori, the major causative agent of gastric cancer, induces DNA damage and inhibits MMR DNA repair. Also, it has been re...... hiện toàn bộ
Colorectal carcinoma development in inducible nitric oxide synthase‐deficient mice with dextran sulfate sodium‐induced ulcerative colitis
Molecular Carcinogenesis - Tập 46 Số 5 - Trang 341-353 - 2007
Darren N. Seril, Jie Liao, Guang‐Yu Yang
AbstractThe overproduction of reactive oxygen and nitrogen species (RONS) may play an important role in ulcerative colitis (UC)‐associated carcinogenesis. In order to study the role of nitric oxide (NO) in UC‐associated colorectal carcinogenesis, the development of colorectal carcinoma was studied using the DSS‐induced and iron‐enhanced model of chronic UC in induc...... hiện toàn bộ
Peroxisome proliferator–activated receptor α in the human breast cancer cell lines MCF‐7 and MDA‐MB‐231
Molecular Carcinogenesis - Tập 34 Số 4 - Trang 165-171 - 2002
K. M. Suchanek, Fiona J. May, J. A. Robinson, Won‐Jae Lee, N. A. Holman, Gregory R. Monteith, Sarah J. Roberts‐Thomson
AbstractPeroxisome proliferator–activated receptor (PPAR) α is a ligand‐activated transcription factor that has been linked with rodent hepatocarcinogenesis. It has been suggested that PPARα mRNA expression levels are an important determinant of rodent hepatic tumorigenicity. Previous work in rat mammary gland epithelial cells showed sign...... hiện toàn bộ
Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin‐induced apoptosis
Molecular Carcinogenesis - Tập 49 Số 4 - Trang 324-336 - 2010
Beena Joy, Rajeeve Sivadasan, Abraham T. Emilia, Mohan John, Praveen K. Sobhan, Mahendra Seervi, Santhoshkumar T.R.
AbstractXIAP is an important antiapoptotic protein capable of conferring resistance to cancer cells. Embelin, the small molecular inhibitor of XIAP, possesses wide spectrum of biological activities with strong inhibition of nuclear factor kappa B and downstream antiapoptotic genes. However, the mechanism of its cell death induction is not known. Our studies using c...... hiện toàn bộ
Prostate cancer stem/progenitor cells: Identification, characterization, and implications
Molecular Carcinogenesis - Tập 46 Số 1 - Trang 1-14 - 2007
Dean G. Tang, Lubna Patrawala, Tammy Calhoun, Bobby Bhatia, Grace Choy, Robin Schneider‐Broussard, Collene Jeter
AbstractSeveral solid tumors have now been shown to contain stem cell‐like cells called cancer stem cells (CSC). These cells, although generally rare, appear to be highly tumorigenic and may be the cells that drive tumor formation, maintain tumor homeostasis, and mediate tumor metastasis. In this Perspective, we first provide our insight ...... hiện toàn bộ
Gemcitabine‐induced epithelial‐mesenchymal transition‐like changes sustain chemoresistance of pancreatic cancer cells of mesenchymal‐like phenotype
Molecular Carcinogenesis - Tập 58 Số 11 - Trang 1985-1997 - 2019
Mehdi El Amrani, François Corfiotti, Matthieu Corvaisier, Romain Vasseur, Maxence Fulbert, Cécile Skrzypczyk, Anne‐Claire Deshorgues, Viviane Gnemmi, David Tulasne, Fatima Lahdaoui, Audrey Vincent, François‐René Pruvot, Isabelle Van Seuningen, Guillemette Huet, Stéphanie Truant
AbstractGrowing body of evidence suggests that epithelial‐mesenchymal transition (EMT) is a critical process in tumor progression and chemoresistance in pancreatic cancer (PC). The aim of this study was to analyze the role of EMT‐like changes in acquisition of resistance to gemcitabine in pancreatic cells of the mesenchymal or epithelial phenotype. Therefore, chemo...... hiện toàn bộ
Polyamine‐mediated regulation of protein acetylation in murine skin and tumors
Molecular Carcinogenesis - Tập 46 Số 8 - Trang 611-617 - 2007
Gang Wei, Cheryl A. Hobbs, Karen DeFeo, Candace S. Hayes, Susan K. Gilmour
AbstractOverexpression of ornithine decarboxylase (ODC), resulting in increased polyamine metabolism, is a common feature of epithelial tumors. Polyamines play a complex role in promoting tumor development, affecting diverse cellular processes, including gene expression. One way polyamines may affect gene expression is to modulate the multiprotein complexes compris...... hiện toàn bộ
Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her‐2/neu (erbB‐2) oncogene‐induced malignant transformation
Molecular Carcinogenesis - Tập 41 Số 3 - Trang 164-178 - 2004
Javier A. Menéndez, Inderjit Mehmi, Vishal Verma, Poh K. Teng, Ruth Lupu
AbstractWe designed our experiments to evaluate whether fatty acid synthase (FAS), a lipogenic enzyme linked to tumor virulence in population studies of human cancer, is necessary for the malignant transformation induced by Her‐2/neu (erbB‐2) oncogene, which is overexpressed not only in invasive breast cancer but also in premalignant atypical duct proliferations an...... hiện toàn bộ
Ki‐ras oncogene mutations in tumors and DNA adducts formed by benz[j]aceanthrylene and benzo[a]pyrene in the lungs of strain A/J mice
Molecular Carcinogenesis - Tập 8 Số 3 - Trang 186-192 - 1993
Marc J. Mass, Jeffrey A. Ross, Stephen Nesnow, Anita J. Jeffers, Garret B. Nelson, Anthony J. Galati, Gary D. Stoner
AbstractStrain A/J mice received intraperitoneal injections of benz[j]aceanthrylene (B[j]A) or benzo[a]pyrene (B[a]P). At 24, 48, and 72 h, lung tissues were removed for analysis of B[a]P‐ or B[j]A‐derived...... hiện toàn bộ
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