Molecular Carcinogenesis

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Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin‐induced apoptosis
Molecular Carcinogenesis - Tập 49 Số 4 - Trang 324-336 - 2010
Beena Joy, Rajeeve Sivadasan, Abraham T. Emilia, Mohan John, Praveen K. Sobhan, Mahendra Seervi, Santhoshkumar T.R.
AbstractXIAP is an important antiapoptotic protein capable of conferring resistance to cancer cells. Embelin, the small molecular inhibitor of XIAP, possesses wide spectrum of biological activities with strong inhibition of nuclear factor kappa B and downstream antiapoptotic genes. However, the mechanism of its cell death induction is not known. Our studies using c...... hiện toàn bộ
Prostate cancer stem/progenitor cells: Identification, characterization, and implications
Molecular Carcinogenesis - Tập 46 Số 1 - Trang 1-14 - 2007
Dean G. Tang, Lubna Patrawala, Tammy Calhoun, Bobby Bhatia, Grace Choy, Robin Schneider‐Broussard, Collene Jeter
AbstractSeveral solid tumors have now been shown to contain stem cell‐like cells called cancer stem cells (CSC). These cells, although generally rare, appear to be highly tumorigenic and may be the cells that drive tumor formation, maintain tumor homeostasis, and mediate tumor metastasis. In this Perspective, we first provide our insight ...... hiện toàn bộ
Gemcitabine‐induced epithelial‐mesenchymal transition‐like changes sustain chemoresistance of pancreatic cancer cells of mesenchymal‐like phenotype
Molecular Carcinogenesis - Tập 58 Số 11 - Trang 1985-1997 - 2019
Mehdi El Amrani, François Corfiotti, Matthieu Corvaisier, Romain Vasseur, Maxence Fulbert, Cécile Skrzypczyk, Anne‐Claire Deshorgues, Viviane Gnemmi, David Tulasne, Fatima Lahdaoui, Audrey Vincent, François‐René Pruvot, Isabelle Van Seuningen, Guillemette Huet, Stéphanie Truant
AbstractGrowing body of evidence suggests that epithelial‐mesenchymal transition (EMT) is a critical process in tumor progression and chemoresistance in pancreatic cancer (PC). The aim of this study was to analyze the role of EMT‐like changes in acquisition of resistance to gemcitabine in pancreatic cells of the mesenchymal or epithelial phenotype. Therefore, chemo...... hiện toàn bộ
Polyamine‐mediated regulation of protein acetylation in murine skin and tumors
Molecular Carcinogenesis - Tập 46 Số 8 - Trang 611-617 - 2007
Gang Wei, Cheryl A. Hobbs, Karen DeFeo, Candace S. Hayes, Susan K. Gilmour
AbstractOverexpression of ornithine decarboxylase (ODC), resulting in increased polyamine metabolism, is a common feature of epithelial tumors. Polyamines play a complex role in promoting tumor development, affecting diverse cellular processes, including gene expression. One way polyamines may affect gene expression is to modulate the multiprotein complexes compris...... hiện toàn bộ
BRCA1 and acetyl‐CoA carboxylase: The metabolic syndrome of breast cancer
Molecular Carcinogenesis - Tập 47 Số 2 - Trang 157-163 - 2008
Joan Brunet, Alejandro Vázquez‐Martín, Rámón Colomer, Begoña Graña-Suárez, Begoña Martı́n-Castillo, Javier A. Menéndez
AbstractBreast cancer‐associated mutations affecting the highly‐conserved C‐terminal BRCT domains of the tumor suppressor gene breast cancer susceptibility gene 1 (BRCA1) fully disrupt the ability of BRCA1 to interact with acetyl co...... hiện toàn bộ
Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her‐2/neu (erbB‐2) oncogene‐induced malignant transformation
Molecular Carcinogenesis - Tập 41 Số 3 - Trang 164-178 - 2004
Javier A. Menéndez, Inderjit Mehmi, Vishal Verma, Poh K. Teng, Ruth Lupu
AbstractWe designed our experiments to evaluate whether fatty acid synthase (FAS), a lipogenic enzyme linked to tumor virulence in population studies of human cancer, is necessary for the malignant transformation induced by Her‐2/neu (erbB‐2) oncogene, which is overexpressed not only in invasive breast cancer but also in premalignant atypical duct proliferations an...... hiện toàn bộ
Ki‐ras oncogene mutations in tumors and DNA adducts formed by benz[j]aceanthrylene and benzo[a]pyrene in the lungs of strain A/J mice
Molecular Carcinogenesis - Tập 8 Số 3 - Trang 186-192 - 1993
Marc J. Mass, Jeffrey A. Ross, Stephen Nesnow, Anita J. Jeffers, Garret B. Nelson, Anthony J. Galati, Gary D. Stoner
AbstractStrain A/J mice received intraperitoneal injections of benz[j]aceanthrylene (B[j]A) or benzo[a]pyrene (B[a]P). At 24, 48, and 72 h, lung tissues were removed for analysis of B[a]P‐ or B[j]A‐derived...... hiện toàn bộ
Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity
Molecular Carcinogenesis - Tập 2 Số 4 - Trang 192-198 - 1989
Toshifumi Aoyama, Frank J. Gonzalez, Harry V. Gelboin
AbstractThe vaccinia virus cDNA expression system was used to produce human cytochrome P450 IA2 in a hepatoma cell line that is devoid of significant basal levels of P450. The expressed enzyme yielded a reduced carbon monoxide‐bound difference spectrum with a λmax of 449 nm. Catalytic activities and mutagen activation ability of the human enzym...... hiện toàn bộ
Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage
Molecular Carcinogenesis - Tập 3 Số 4 - Trang 188-197 - 1990
Lars H. Breimer
Expression of FOXJ1 in hepatocellular carcinoma: Correlation with patients' prognosis and tumor cell proliferation
Molecular Carcinogenesis - Tập 52 Số 8 - Trang 647-659 - 2013
Hongwei Chen, Xiaodong Huang, Hong‐Chen Li, Song He, Runzhou Ni, Cui‐Hua Chen, Peng Chen, Gang Wu, Guihua Wang, Yingying Wang, Yunhong Zhao, Yixin Zhang, Aiguo Shen, Huimin Wang
AbstractFOXJ1 is a member of the forkhead box (FOX) family of transcription factors. Recent studies suggested that FOXJ1 may function as a tumor suppressor gene in breast cancer. To investigate the potential roles of FOXJ1 in hepatocellular carcinoma (HCC), expression of FOXJ1 was first examined in eight paired frozen HCC and adjacent noncancerous liver tissues by ...... hiện toàn bộ
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