Molecular Carcinogenesis
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Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin‐induced apoptosis
Molecular Carcinogenesis - Tập 49 Số 4 - Trang 324-336 - 2010
AbstractXIAP is an important antiapoptotic protein capable of conferring
resistance to cancer cells. Embelin, the small molecular inhibitor of XIAP,
possesses wide spectrum of biological activities with strong inhibition of
nuclear factor kappa B and downstream antiapoptotic genes. However, the
mechanism of its cell death induction is not known. Our studies using colon
cancer cells lacking p53 and...
Prostate cancer stem/progenitor cells: Identification, characterization, and implications
Molecular Carcinogenesis - Tập 46 Số 1 - Trang 1-14 - 2007
AbstractSeveral solid tumors have now been shown to contain stem cell‐like cells
called cancer stem cells (CSC). These cells, although generally rare, appear to
be highly tumorigenic and may be the cells that drive tumor formation, maintain
tumor homeostasis, and mediate tumor metastasis. In this Perspective, we first
provide our insight on how a CSC should be defined. We then summarize our
curren...
Gemcitabine‐induced epithelial‐mesenchymal transition‐like changes sustain chemoresistance of pancreatic cancer cells of mesenchymal‐like phenotype
Molecular Carcinogenesis - Tập 58 Số 11 - Trang 1985-1997 - 2019
AbstractGrowing body of evidence suggests that epithelial‐mesenchymal transition
(EMT) is a critical process in tumor progression and chemoresistance in
pancreatic cancer (PC). The aim of this study was to analyze the role of
EMT‐like changes in acquisition of resistance to gemcitabine in pancreatic cells
of the mesenchymal or epithelial phenotype. Therefore, chemoresistant BxPC‐3,
Capan‐2, Panc‐1...
Polyamine‐mediated regulation of protein acetylation in murine skin and tumors
Molecular Carcinogenesis - Tập 46 Số 8 - Trang 611-617 - 2007
AbstractOverexpression of ornithine decarboxylase (ODC), resulting in increased
polyamine metabolism, is a common feature of epithelial tumors. Polyamines play
a complex role in promoting tumor development, affecting diverse cellular
processes, including gene expression. One way polyamines may affect gene
expression is to modulate the multiprotein complexes comprised of transcription
factors and c...
BRCA1 and acetyl‐CoA carboxylase: The metabolic syndrome of breast cancer
Molecular Carcinogenesis - Tập 47 Số 2 - Trang 157-163 - 2008
AbstractBreast cancer‐associated mutations affecting the highly‐conserved
C‐terminal BRCT domains of the tumor suppressor gene breast cancer
susceptibility gene 1 (BRCA1) fully disrupt the ability of BRCA1 to interact
with acetyl coenzyme A carboxylase alpha (ACCA), the rate‐limiting enzyme
catalyzing de novo fatty acid biogenesis. Specifically, BRCA1 interacts solely
with the phosphorylated (inac...
Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her‐2/neu (erbB‐2) oncogene‐induced malignant transformation
Molecular Carcinogenesis - Tập 41 Số 3 - Trang 164-178 - 2004
AbstractWe designed our experiments to evaluate whether fatty acid synthase
(FAS), a lipogenic enzyme linked to tumor virulence in population studies of
human cancer, is necessary for the malignant transformation induced by Her‐2/neu
(erbB‐2) oncogene, which is overexpressed not only in invasive breast cancer but
also in premalignant atypical duct proliferations and in ductal carcinoma in
situ of ...
Ki‐ras oncogene mutations in tumors and DNA adducts formed by benz[j]aceanthrylene and benzo[a]pyrene in the lungs of strain A/J mice
Molecular Carcinogenesis - Tập 8 Số 3 - Trang 186-192 - 1993
AbstractStrain A/J mice received intraperitoneal injections of
benz[j]aceanthrylene (B[j]A) or benzo[a]pyrene (B[a]P). At 24, 48, and 72 h,
lung tissues were removed for analysis of B[a]P‐ or B[j]A‐derived DNA adduct
formation during the first 3 d of exposure. One group of mice exposed to these
hydrocarbons was kept for 8 mo to determine lung tumor multiplicity, the
occurrence of mutations in codo...
Human cDNA‐Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity
Molecular Carcinogenesis - Tập 2 Số 4 - Trang 192-198 - 1989
AbstractThe vaccinia virus cDNA expression system was used to produce human
cytochrome P450 IA2 in a hepatoma cell line that is devoid of significant basal
levels of P450. The expressed enzyme yielded a reduced carbon monoxide‐bound
difference spectrum with a λmax of 449 nm. Catalytic activities and mutagen
activation ability of the human enzyme were assessed and directly compared with
results obt...
Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis: The role of dna base damage
Molecular Carcinogenesis - Tập 3 Số 4 - Trang 188-197 - 1990
Expression of FOXJ1 in hepatocellular carcinoma: Correlation with patients' prognosis and tumor cell proliferation
Molecular Carcinogenesis - Tập 52 Số 8 - Trang 647-659 - 2013
AbstractFOXJ1 is a member of the forkhead box (FOX) family of transcription
factors. Recent studies suggested that FOXJ1 may function as a tumor suppressor
gene in breast cancer. To investigate the potential roles of FOXJ1 in
hepatocellular carcinoma (HCC), expression of FOXJ1 was first examined in eight
paired frozen HCC and adjacent noncancerous liver tissues by Western blot, and
we found that F...
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