Molecular Carcinogenesis
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Colorectal carcinoma development in inducible nitric oxide synthase‐deficient mice with dextran sulfate sodium‐induced ulcerative colitisAbstract The overproduction of reactive oxygen and nitrogen species (RONS) may play an important role in ulcerative colitis (UC)‐associated carcinogenesis. In order to study the role of nitric oxide (NO) in UC‐associated colorectal carcinogenesis, the development of colorectal carcinoma was studied using the DSS‐induced and iron‐enhanced model of chronic UC in induc... ... hiện toàn bộ
Molecular Carcinogenesis - Tập 46 Số 5 - Trang 341-353 - 2007
Peroxisome proliferator–activated receptor α in the human breast cancer cell lines MCF‐7 and MDA‐MB‐231Abstract Peroxisome proliferator–activated receptor (PPAR) α is a ligand‐activated transcription factor that has been linked with rodent hepatocarcinogenesis. It has been suggested that PPARα mRNA expression levels are an important determinant of rodent hepatic tumorigenicity. Previous work in rat mammary gland epithelial cells showed sign... ... hiện toàn bộ
Molecular Carcinogenesis - Tập 34 Số 4 - Trang 165-171 - 2002
Diallyl trisulfide‐induced apoptosis in human cancer cells is linked to checkpoint kinase 1‐mediated mitotic arrestAbstract Growth suppressive effect of diallyl trisulfide (DATS), a promising cancer chemopreventive constituent of garlic, against cultured human cancer cells correlates with checkpoint kinase 1 (Chk1)‐mediated mitotic arrest, but the fate of the cells arrested in mitosis remains elusive. Using LNCaP and HCT‐116 human cancer cells as a model, we now demonstrate that... ... hiện toàn bộ
Molecular Carcinogenesis - Tập 48 Số 11 - Trang 1018-1029 - 2009
Ki‐ras oncogene mutations in tumors and DNA adducts formed by benz[j]aceanthrylene and benzo[a]pyrene in the lungs of strain A/J miceAbstract Strain A/J mice received intraperitoneal injections of benz[j ]aceanthrylene (B[j ]A) or benzo[a ]pyrene (B[a ]P). At 24, 48, and 72 h, lung tissues were removed for analysis of B[a ]P‐ or B[j ]A‐derived... ... hiện toàn bộ
Molecular Carcinogenesis - Tập 8 Số 3 - Trang 186-192 - 1993
Suppression of radiation‐induced neoplastic transformation by overexpression of mitochondrial superoxide dismutaseAbstract Manganese superoxide dismutase (MnSOD) scavenges toxic superoxide radicals produced in the mitochondria. Transfection of the human MnSOD gene into mouse C3H 10T1/2 cells resulted in production of active MnSOD, which was properly transported into mitochondria. Overexpression of MnSOD protected cells from radiation‐, but not chemically‐induced neoplastic tran... ... hiện toàn bộ
Molecular Carcinogenesis - Tập 6 Số 4 - Trang 238-242 - 1992
BRCA1 and acetyl‐CoA carboxylase: The metabolic syndrome of breast cancerAbstract Breast cancer‐associated mutations affecting the highly‐conserved C‐terminal BRCT domains of the tumor suppressor gene br east ca ncer susceptibility gene 1 (BRCA1) fully disrupt the ability of BRCA1 to interact with a cetyl c o... ... hiện toàn bộ
Molecular Carcinogenesis - Tập 47 Số 2 - Trang 157-163 - 2008
Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her‐2/neu (erbB‐2) oncogene‐induced malignant transformationAbstract We designed our experiments to evaluate whether fatty acid synthase (FAS), a lipogenic enzyme linked to tumor virulence in population studies of human cancer, is necessary for the malignant transformation induced by Her‐2/neu (erbB‐2) oncogene, which is overexpressed not only in invasive breast cancer but also in premalignant atypical duct proliferations an... ... hiện toàn bộ
Molecular Carcinogenesis - Tập 41 Số 3 - Trang 164-178 - 2004
KAI1, A prostate metastasis suppressor: Prediction of solvated structure and interactions with binding partners; integrins, cadherins, and cell‐surface receptor proteins†Abstract The solution structure of the transmembrane‐4 superfamily protein KAI1, a recently identified prostate cancer metastasis suppressor gene that encodes a 267–amino acid protein, was modeled. The structure of this four‐helical transmembrane protein was developed by defining and modeling sections individually. A complete three‐dimensional structure for the solv... ... hiện toàn bộ
Molecular Carcinogenesis - Tập 32 Số 3 - Trang 139-153 - 2001
Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin‐induced apoptosisAbstract XIAP is an important antiapoptotic protein capable of conferring resistance to cancer cells. Embelin, the small molecular inhibitor of XIAP, possesses wide spectrum of biological activities with strong inhibition of nuclear factor kappa B and downstream antiapoptotic genes. However, the mechanism of its cell death induction is not known. Our studies using c... ... hiện toàn bộ
Molecular Carcinogenesis - Tập 49 Số 4 - Trang 324-336 - 2010
Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker ratAbstract Somatic events leading to the inactivation of tumor suppressor genes often involve chromosomal alterations that can be detected as loss of heterozygosity(a). In the Eker rat, spontaneous tumors of the kidney, uterus, and spleen develop as a result of a germline mutation of the tuberous sclerosis 2(Tsc2 ) gene. We examined the patte... ... hiện toàn bộ
Molecular Carcinogenesis - Tập 14 Số 1 - Trang 28-36 - 1995
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