Molecular Cancer Therapeutics
SCIE-ISI SCOPUS (2001-2023)
1535-7163
1538-8514
Mỹ
Cơ quản chủ quản: American Association for Cancer Research Inc. , AMER ASSOC CANCER RESEARCH
Lĩnh vực:
Cancer ResearchOncology
Các bài báo tiêu biểu
Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse CancersAbstract
Immunotherapy induces durable responses in a subset of patients with cancer. High tumor mutational burden (TMB) may be a response biomarker for PD-1/PD-L1 blockade in tumors such as melanoma and non–small cell lung cancer (NSCLC). Our aim was to examine the relationship between TMB and outcome in diverse cancers treated with various immunoth... ... hiện toàn bộ
Tập 16 Số 11 - Trang 2598-2608 - 2017
Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor GrowthAbstract The signaling pathway of the receptor tyrosine kinase MET and its ligand hepatocyte growth factor (HGF) is important for cell growth, survival, and motility and is functionally linked to the signaling pathway of VEGF, which is widely recognized as a key effector in angiogenesis and cancer progression. Dysregulation of the MET/VEGF axis is found in a number ... ... hiện toàn bộ
Tập 10 Số 12 - Trang 2298-2308 - 2011
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activityAbstract
The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells, providing unique opportunities for anticancer therapeutic intervention. NVP-BEZ235 is an imidazo[4,5-c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the A... ... hiện toàn bộ
Tập 7 Số 7 - Trang 1851-1863 - 2008
Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast CancerAbstract Glutamine serves as an important source of energy and building blocks for many tumor cells. The first step in glutamine utilization is its conversion to glutamate by the mitochondrial enzyme glutaminase. CB-839 is a potent, selective, and orally bioavailable inhibitor of both splice variants of glutaminase (KGA and GAC). CB-839 had antiproliferative activit... ... hiện toàn bộ
Tập 13 Số 4 - Trang 890-901 - 2014
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted DrugsIn vitroandIn vivoAbstract The serine/threonine kinase Akt lies at a critical signaling node downstream of phosphatidylinositol-3-kinase and is important in promoting cell survival and inhibiting apoptosis. An Akt inhibitor may be particularly useful for cancers in which increased Akt signaling is associated with reduced sensitivity to cytotoxic agents or receptor tyrosine kinase inh... ... hiện toàn bộ
Tập 9 Số 7 - Trang 1956-1967 - 2010
Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and RucaparibAbstract
Anti-PARP drugs were initially developed as catalytic inhibitors to block the repair of DNA single-strand breaks. We recently reported that several PARP inhibitors have an additional cytotoxic mechanism by trapping PARP–DNA complexes, and that both olaparib and niraparib act as PARP poisons at pharmacologic concentrations. Therefore, we have... ... hiện toàn bộ
Tập 13 Số 2 - Trang 433-443 - 2014
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphomaAbstract
A t(2;5) chromosomal translocation resulting in expression of an oncogenic kinase fusion protein known as nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) has been implicated in the pathogenesis of anaplastic large-cell lymphoma (ALCL). PF-2341066 was recently identified as a p.o. bioavailable, small-molecule inhibitor of the catalytic act... ... hiện toàn bộ
Tập 6 Số 12 - Trang 3314-3322 - 2007
Marine natural products as anticancer drugsAbstract
The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of variou... ... hiện toàn bộ
Tập 4 Số 2 - Trang 333-342 - 2005
Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase InhibitorAbstract
Following the discovery of NVP-BEZ235, our first dual pan-PI3K/mTOR clinical compound, we sought to identify additional phosphoinositide 3-kinase (PI3K) inhibitors from different chemical classes with a different selectivity profile. The key to achieve these objectives was to couple a structure-based design approach with intensive pharmacolo... ... hiện toàn bộ
Tập 11 Số 2 - Trang 317-328 - 2012
Cơ chế tác động chủ yếu của halichondrin tổng hợp E7389 là ức chế sự phát triển của vi ống Dịch bởi AI Tóm tắt
E7389, hiện đang trong thử nghiệm lâm sàng giai đoạn I và II, là một dẫn xuất ketone macrocyclic tổng hợp của sản phẩm tự nhiên halichondrin B từ bọt biển biển. Trong khi cơ chế tác động của nó chưa được làm rõ hoàn toàn, mục tiêu chính dường như là tubulin và/hoặc các vi ống có trách nhiệm với việc xây dựng và chức năng đúng đắn của thoi phâ... ... hiện toàn bộ
Tập 4 Số 7 - Trang 1086-1095 - 2005