Molecular Cancer Therapeutics

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Overcoming Erlotinib Resistance in EGFR Mutation–Positive Non–Small Cell Lung Cancer Cells by Targeting Survivin
Molecular Cancer Therapeutics - Tập 11 Số 1 - Trang 204-213 - 2012
Kunio Okamoto, Isamu Okamoto, Erina Hatashita, Kiyoko Kuwata, Haruka Yamaguchi, Aya Kita, Kentaro Yamanaka, Mayumi Ono, Kazuhiko Nakagawa
Abstract Loss of PTEN was recently shown to contribute to resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in EGFR mutation–positive non–small cell lung cancer (NSCLC) through activation of the protein kinase AKT. We previously showed that downregulation of the expression of the antiapoptotic protein survivin by EGFR–TKIs contributes to EGFR–TKI-induced apopto... hiện toàn bộ
Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening
Molecular Cancer Therapeutics - Tập 10 Số 4 - Trang 591-602 - 2011
Timothy J. Guzi, Kamil Paruch, Michael P. Dwyer, Marc Labroli, Fergus Shanahan, Nicole R. Davis, Lorena Taricani, Derek Wiswell, Wolfgang Seghezzi, Ervin Penaflor, Bhagyashree Bhagwat, Wei Wang, Danling Gu, Yunsheng Hsieh, Suining Lee, Ming Liu, David Parry
Abstract Checkpoint kinase 1 (CHK1) is an essential serine/threonine kinase that responds to DNA damage and stalled DNA replication. CHK1 is essential for maintenance of replication fork viability during exposure to DNA antimetabolites. In human tumor cell lines, ablation of CHK1 function during antimetabolite exposure led to accumulation of double-strand DNA breaks and cell death. Here, we extend... hiện toàn bộ
Inhibition of Homologous Recombination and Promotion of Mutagenic Repair of DNA Double-Strand Breaks Underpins Arabinoside–Nucleoside Analogue Radiosensitization
Molecular Cancer Therapeutics - Tập 14 Số 6 - Trang 1424-1433 - 2015
Simon Magin, Maria Papaioannou, Janapriya Saha, Christian Staudt, George Iliakis
Abstract In concurrent chemoradiotherapy, drugs are used to sensitize tumors to ionizing radiation. Although a spectrum of indications for simultaneous treatment with drugs and radiation has been defined, the molecular mechanisms underpinning tumor radiosensitization remain incompletely characterized for several such combinations. Here, we investigate the mechanisms of radiosensitization by the ar... hiện toàn bộ
Combination of antiangiogenesis with chemotherapy for more effective cancer treatment
Molecular Cancer Therapeutics - Tập 7 Số 12 - Trang 3670-3684 - 2008
Jie Ma, David J. Waxman
Abstract Angiogenesis is a hallmark of tumor development and metastasis and is now a validated target for cancer treatment. However, the survival benefits of antiangiogenic drugs have thus far been rather modest, stimulating interest in developing more effective ways to combine antiangiogenic drugs with established chemotherapies. This review discusses recent progress and emerging challenges in th... hiện toàn bộ
Monitoring Tumor Burden in Response to FOLFIRINOX Chemotherapy Via Profiling Circulating Cell-Free DNA in Pancreatic Cancer
Molecular Cancer Therapeutics - Tập 18 Số 1 - Trang 196-203 - 2019
Tao Wei, Qi Zhang, Xiang Li, Wei Su, Guogang Li, Tao Ma, Shunliang Gao, Jianying Lou, Risheng Que, Lei Zheng, Xueli Bai, Qi Zhang
Abstract We aimed to explore the application of circulating cell-free DNA (cfDNA) profiling in monitoring tumor burden in patients with pancreatic ductal adenocarcinoma (PDAC). Thirty-eight patients with advanced PDAC receiving first-line FOLFIRINOX chemotherapy were prospectively enrolled. Next-generation sequencing for a panel of 560 genes covering a wide range of cancer-related loci was perform... hiện toàn bộ
Kaempferol gây ra quá trình apoptosis trong các tế bào u nguyên bào thần kinh đệm qua stress oxy hóa Dịch bởi AI
Molecular Cancer Therapeutics - Tập 6 Số 9 - Trang 2544-2553 - 2007
Vivek Sharma, Christy Joseph, Soumya Ghosh, Anindita Agarwal, Manoj K. Mishra, Ellora Sen
Tóm tắt Mặc dù đã có những tiến bộ gần đây trong việc hiểu rõ cơ chế phân tử liên quan đến tiến triển của u nguyên bào thần kinh đệm, tiên lượng của khối u não ác tính nhất này vẫn tiếp tục ảm đạm. Vì flavonoid kaempferol được biết đến với khả năng ức chế sự phát triển của một số bệnh ung thư ở người, chúng tôi đã nghiên cứu tác động của kaempferol lên các tế bào u nguyên bào thần kinh đệm ở người... hiện toàn bộ
#Glioblastoma #Apoptosis #Oxidative Stress #Flavonoid Kaempferol #ROS #SOD-1 #TRX-1 #Cytokine #Chemokine #Doxorubicin
Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice
Molecular Cancer Therapeutics - Tập 9 Số 6 - Trang 1740-1754 - 2010
Vanessa Fritz, Zohra Benfodda, Geneviève Rodier, Corinne Henriquet, François Iborra, Christophe Avancès, Yves Allory, Alexandre de la Taille, Stéphane Culine, H. Blancou, Jean‐Paul Cristol, Françoise Michel, Claude Sardet, Lluís Fajas
Abstract Increased de novo fatty acid (FA) synthesis is one hallmark of tumor cells, including prostate cancer. We present here our most recent results showing that lipid composition in human prostate cancer is characterized by an increased ratio of monounsaturated FA to saturated FA, compared with normal prostate, and evidence the overexpression of the lipogenic enzyme stearoyl-CoA desaturase 1 (... hiện toàn bộ
A role for macroautophagy in protection against 4-hydroxytamoxifen–induced cell death and the development of antiestrogen resistance
Molecular Cancer Therapeutics - Tập 7 Số 9 - Trang 2977-2987 - 2008
Julia S. Samaddar, Virgil T. Gaddy, Jennifer Duplantier, Sudharsan Periyasamy Thandavan, Manish A. Shah, Marlena J. Smith, Darren D. Browning, James V. Rawson, Sylvia B. Smith, John T. Barrett, Patricia V. Schoenlein
Abstract This study identifies macroautophagy as a key mechanism of cell survival in estrogen receptor–positive (ER+) breast cancer cells undergoing treatment with 4-hydroxytamoxifen (4-OHT). This selective ER modifier is an active metabolite of tamoxifen commonly used for the treatment of breast cancer. Our study provides the following key findings: (a) only 20% to 25% of breast cancer cells trea... hiện toàn bộ
Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?
Molecular Cancer Therapeutics - Tập 9 Số 5 - Trang 1092-1099 - 2010
Issam Ben Sahra, Y. Le Marchand‐Brustel, Jean‐François Tanti, Frédéric Bost
Abstract Metformin is the most widely used antidiabetic drug in the world, and there is increasing evidence of a potential efficacy of this agent as an anticancer drug. First, epidemiological studies show a decrease in cancer incidence in metformin-treated patients. Second, metformin decreases insulin resistance and indirectly reduces insulin level, a beneficial effect because insulin promotes can... hiện toàn bộ
Marine natural products as anticancer drugs
Molecular Cancer Therapeutics - Tập 4 Số 2 - Trang 333-342 - 2005
Thomas L. Simmons, Eric H. Andrianasolo, Kerry L. McPhail, Patricia M. Flatt, William H. Gerwick
Abstract The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range... hiện toàn bộ
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