Molecular Cancer Therapeutics

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Targeting the Replication Checkpoint Using SCH 900776, a Potent and Functionally Selective CHK1 Inhibitor Identified via High Content Screening
Molecular Cancer Therapeutics - Tập 10 Số 4 - Trang 591-602 - 2011
Timothy J. Guzi, Kamil Paruch, Michael P. Dwyer, Marc Labroli, Fergus Shanahan, Nicole R. Davis, Lorena Taricani, Derek Wiswell, Wolfgang Seghezzi, Ervin Penaflor, Bhagyashree Bhagwat, Wei Wang, Danling Gu, Yunsheng Hsieh, Suining Lee, Ming Liu, David Parry
Abstract Checkpoint kinase 1 (CHK1) is an essential serine/threonine kinase that responds to DNA damage and stalled DNA replication. CHK1 is essential for maintenance of replication fork viability during exposure to DNA antimetabolites. In human tumor cell lines, ablation of CHK1 function during antimetabolite exposure led to accumulation of double-s...... hiện toàn bộ
Inhibition of Homologous Recombination and Promotion of Mutagenic Repair of DNA Double-Strand Breaks Underpins Arabinoside–Nucleoside Analogue Radiosensitization
Molecular Cancer Therapeutics - Tập 14 Số 6 - Trang 1424-1433 - 2015
Simon Magin, Maria Papaioannou, Janapriya Saha, Christian Staudt, George Iliakis
Abstract In concurrent chemoradiotherapy, drugs are used to sensitize tumors to ionizing radiation. Although a spectrum of indications for simultaneous treatment with drugs and radiation has been defined, the molecular mechanisms underpinning tumor radiosensitization remain incompletely characterized for several such combinations. Here, we investigat...... hiện toàn bộ
Combination of antiangiogenesis with chemotherapy for more effective cancer treatment
Molecular Cancer Therapeutics - Tập 7 Số 12 - Trang 3670-3684 - 2008
Jie Ma, David J. Waxman
Abstract Angiogenesis is a hallmark of tumor development and metastasis and is now a validated target for cancer treatment. However, the survival benefits of antiangiogenic drugs have thus far been rather modest, stimulating interest in developing more effective ways to combine antiangiogenic drugs with established chemotherapies. This review discuss...... hiện toàn bộ
Monitoring Tumor Burden in Response to FOLFIRINOX Chemotherapy Via Profiling Circulating Cell-Free DNA in Pancreatic Cancer
Molecular Cancer Therapeutics - Tập 18 Số 1 - Trang 196-203 - 2019
Tao Wei, Qi Zhang, Xiang Li, Wei Su, Guogang Li, Tao Ma, Shunliang Gao, Jianying Lou, Risheng Que, Lei Zheng, Xueli Bai, Qi Zhang
Abstract We aimed to explore the application of circulating cell-free DNA (cfDNA) profiling in monitoring tumor burden in patients with pancreatic ductal adenocarcinoma (PDAC). Thirty-eight patients with advanced PDAC receiving first-line FOLFIRINOX chemotherapy were prospectively enrolled. Next-generation sequencing for a panel of 560 genes covering...... hiện toàn bộ
Kaempferol gây ra quá trình apoptosis trong các tế bào u nguyên bào thần kinh đệm qua stress oxy hóa Dịch bởi AI
Molecular Cancer Therapeutics - Tập 6 Số 9 - Trang 2544-2553 - 2007
Vivek Sharma, Christy Joseph, Soumya Ghosh, Anindita Agarwal, Manoj K. Mishra, Ellora Sen
Tóm tắt Mặc dù đã có những tiến bộ gần đây trong việc hiểu rõ cơ chế phân tử liên quan đến tiến triển của u nguyên bào thần kinh đệm, tiên lượng của khối u não ác tính nhất này vẫn tiếp tục ảm đạm. Vì flavonoid kaempferol được biết đến với khả năng ức chế sự phát triển của một số bệnh ung thư ở người, chúng tôi đã nghiên cứu tác động của kaempferol lên các tế bào u...... hiện toàn bộ
#Glioblastoma #Apoptosis #Oxidative Stress #Flavonoid Kaempferol #ROS #SOD-1 #TRX-1 #Cytokine #Chemokine #Doxorubicin
Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas
Molecular Cancer Therapeutics - Tập 8 Số 11 - Trang 3024-3035 - 2009
Kaiji Hu, Cathy Lee, Dexin Qiu, Abbas Fotovati, Alastair Davies, Samah Abu‐Ali, Daniel Wai, Elizabeth R. Lawlor, Timothy J. Triche, Catherine J. Pallen, Sandra E. Dunn
Abstract Rhabdomyosarcoma, consisting of alveolar (aRMS) and embryonal (eRMS) subtypes, is the most common type of sarcoma in children. Currently, there are no targeted drug therapies available for rhabdomyosarcoma. In searching for new molecular therapeutic targets, we carried out genome-wide small interfering RNA (siRNA) library screens targeting h...... hiện toàn bộ
ATP Citrate Lyase Mediates Resistance of Colorectal Cancer Cells to SN38
Molecular Cancer Therapeutics - Tập 12 Số 12 - Trang 2782-2791 - 2013
Yunfei Zhou, Lakshmi Reddy Bollu, Federico Tozzi, Xiangcang Ye, Rajat Bhattacharya, Guang Gao, Elizabeth Dupre, Ling Xia, Jia Lu, Fan Fan, Seth Bellister, Lee M. Ellis, Weihua Zhang
AbstractCombination chemotherapy is standard for metastatic colorectal cancer; however, nearly all patients develop drug resistance. Understanding the mechanisms that lead to resistance to individual chemotherapeutic agents may enable identification of novel targets and more effective therapy. Irinotecan is commonly used in first- and second-line therapy for patien...... hiện toàn bộ
A Bispecific HER2-Targeting FynomAb with Superior Antitumor Activity and Novel Mode of Action
Molecular Cancer Therapeutics - Tập 13 Số 8 - Trang 2030-2039 - 2014
Simon Brack, Isabella Attinger-Toller, Babette Schade, Frédéric Mourlane, Kristina Klupsch, Richard Woods, Helen Hachemi, Ulrike von der Bey, Susann Koenig-Friedrich, Julian Bertschinger, Dragan Grabulovski
Abstract Upregulation of HER2 is a hallmark of 20% to 30% of invasive breast cancers, rendering this receptor an attractive target for cancer therapy. Although HER2-targeting agents have provided substantial clinical benefit as cancer therapeutics, there is a need for the development of new agents aiming at circumventing anti-HER2 resistance. On the ...... hiện toàn bộ
CXCR4 Protein Epitope Mimetic Antagonist POL5551 Disrupts Metastasis and Enhances Chemotherapy Effect in Triple-Negative Breast Cancer
Molecular Cancer Therapeutics - Tập 14 Số 11 - Trang 2473-2485 - 2015
Jingyu Xiang, Michelle A. Hurchla, Francesca Fontana, Xinming Su, Sarah R. Amend, Alison K. Esser, Garry J. Douglas, Chidananda Mudalagiriyappa, Kathryn E. Luker, Timothy Pluard, Foluso O. Ademuyiwa, Bárbara Romagnoli, Gérald Tuffin, Éric Chevalier, Gary D. Luker, Michael Bauer, Johann Zimmermann, Rebecca Aft, Klaus Dembowsky, Katherine N. Weilbaecher
Abstract The SDF-1 receptor CXCR4 has been associated with early metastasis and poorer prognosis in breast cancers, especially the most aggressive triple-negative subtype. In line with previous reports, we found that tumoral CXCR4 expression in patients with locally advanced breast cancer was associated with increased metastases and rapid tumor progr...... hiện toàn bộ
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted DrugsIn vitroandIn vivo
Molecular Cancer Therapeutics - Tập 9 Số 7 - Trang 1956-1967 - 2010
Hiroshi Hirai, Hiroshi Sootome, Yoko Nakatsuru, Katsuyoshi Miyama, Shunsuke Taguchi, Kyoko Tsujioka, Yoko Ueno, Harold Hatch, Pradip K. Majumder, Bo‐Sheng Pan, Hidehito Kotani
AbstractThe serine/threonine kinase Akt lies at a critical signaling node downstream of phosphatidylinositol-3-kinase and is important in promoting cell survival and inhibiting apoptosis. An Akt inhibitor may be particularly useful for cancers in which increased Akt signaling is associated with reduced sensitivity to cytotoxic agents or receptor tyrosine kinase inh...... hiện toàn bộ
Tổng số: 148   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10