Malaria Journal
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Interpreting malaria age-prevalence and incidence curves: a simulation study of the effects of different types of heterogeneity
Malaria Journal - Tập 9 - Trang 1-9 - 2010
Individuals in a malaria endemic community differ from one another. Many of
these differences, such as heterogeneities in transmission or treatment-seeking
behaviour, affect malaria epidemiology. The different kinds of heterogeneity are
likely to be correlated. Little is known about their impact on the shape of
age-prevalence and incidence curves. In this study, the effects of heterogeneity
in tra...
Costs analysis of the treatment of imported malaria
Malaria Journal - Tập 11 - Trang 1-5 - 2012
To document the status of imported malaria infections and estimate the costs of
treating of patients hospitalized with the diagnosis of imported malaria in the
Slovak Republic during 2003 to 2008. Calculating and comparing the direct and
indirect costs of treatment of patients diagnosed with imported malaria (ICD-10:
B50 - B54) who used and not used chemoprophylaxis. The target sample included 19
...
Acceptability and efficacy of intra-rectal quinine alkaloids as a pre-transfer treatment of non-per os malaria in peripheral health care facilities in Mopti, Mali
Malaria Journal - Tập 6 - Trang 1-8 - 2007
The acceptability and efficacy of a new kit with a new formulation of quinine
alkaloids designed for the intra-rectal administration in the treatment of
non-per os malaria was assessed in the peripheral health care system of Mopti,
Mali. A single-arm trial was conducted from August 2003 to January 2004. An
initial dose of diluted quinine alkaloids (20 mg/kg Quinimax®) was administered
by the intra...
Nutritional status in young children prior to the malaria transmission season in Burkina Faso and Mali, and its impact on the incidence of clinical malaria
Malaria Journal - Tập 20 - Trang 1-13 - 2021
Malaria and malnutrition remain major problems in Sahel countries, especially in
young children. The direct effect of malnutrition on malaria remains poorly
understood, and may have important implications for malaria control. In this
study, nutritional status and the association between malnutrition and
subsequent incidence of symptomatic malaria were examined in children in Burkina
Faso and Mali ...
A progressive declining in the burden of malaria in north-eastern Tanzania
Malaria Journal - Tập 9 - Trang 1-9 - 2010
The planning and assessment of malaria interventions is complicated due to
fluctuations in the burden of malaria over time. Recently, it has been reported
that the burden of malaria in some parts of Africa has declined. However,
community-based longitudinal data are sparse and the reasons for the apparent
decline are not well understood. Malaria prevalence and morbidity have been
monitored in two ...
Implementation research of a cluster randomized trial evaluating the implementation and effectiveness of intermittent preventive treatment for malaria using dihydroartemisinin-piperaquine on reducing malaria burden in school-aged children in Tanzania: methodology, challenges, and mitigation
Malaria Journal - Tập 22 - Trang 1-16 - 2023
It has been more than 20 years since the malaria epidemiologic shift to
school-aged children was noted. In the meantime, school-aged children
(5–15 years) have become increasingly more vulnerable with asymptomatic malaria
prevalence reaching up to 70%, making them reservoirs for subsequent
transmission of malaria in the endemic communities. Intermittent Preventive
Treatment of malaria in schoolchi...
Malaria prevalence and long-lasting insecticidal net use in rural western Uganda: results of a cross-sectional survey conducted in an area of highly variable malaria transmission intensity
Malaria Journal - Tập 20 Số 1 - 2021
Abstract Background Long-lasting insecticidal nets (LLINs) remain a cornerstone
of malaria control, but strategies to sustain universal coverage and high rates
of use are not well-defined. A more complete understanding of context-specific
factors, including transmission intensity and access to health facilities, may
inform sub-district distribution approaches and tailored messaging campaigns.
Meth...
Characterization of Pb51 in Plasmodium berghei as a malaria vaccine candidate targeting both asexual erythrocytic proliferation and transmission
Malaria Journal - Tập 16 - Trang 1-10 - 2017
A vaccine that targets multiple developmental stages of malaria parasites would
be an effective tool for malaria control and elimination. A conserved gene in
Plasmodium, the Plasmodium berghei gene (PBANKA_020570) encoding a 51 kDa
protein (pb51 gene), was identified through search of the PlasmoDB database
using a combination of expression and protein localization criteria. A partial
domain of the...
Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict pregnancy outcomes
Malaria Journal - Tập 17 - Trang 1-14 - 2018
Maternal malaria is a tropical scourge associated with poor pregnancy outcomes.
Women become resistant to Plasmodium falciparum pregnancy malaria as they
acquire antibodies to the variant surface antigen VAR2CSA, a leading vaccine
candidate. Because malaria infection may increase VAR2CSA antibody levels and
thereby confound analyses of immune protection, gravidity-dependent changes in
antibody lev...
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