Lupus

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Clinical significance of serum and urine prolactin levels in lupus glomerulonephritis
Lupus - Tập 7 Số 6 - Trang 387-391 - 1998
J M Miranda, Rodrigo Prieto, Ramón Paniagua, Gloria García, Dante Amato, Leonor Barile, Luis J. Jara
Prolactin (PRL) has been involved in the pathogenesis of systemic lupus erythematosus (SLE) and hyperprolactinemia has been connected with systemic activity. However, the clinical significance of PRL has not been investigated in lupus glomerulonephritis (GN). Methods: We studied SLE patients (ACR criteria) with biopsy-proven renal disease. Renal histology was classified according to World...... hiện toàn bộ
Hematopoietic stem cell transplant for systemic lupus erythematosus: Interferon regulatory factor 7 activation correlates with the IFN signature and recurrent disease
Lupus - Tập 20 Số 9 - Trang 975-980 - 2011
SE Sweeney
The expression and activation of regulatory factors (IRF) and rinterferon (IFN) response genes were evaluated in a patient treated with autologous hematopoietic stem cell transplant (HSCT) for refractory systemic lupus erythematosus (SLE). In SLE patients, genetic variants of IRF5 and IRF7 have been associated with increased serum IFNα levels, suggesting a pathogenic role in the type I IF...... hiện toàn bộ
Extrahepatic manifestations in chronic hepatitis C virus carriers
Lupus - Tập 24 Số 4-5 - Trang 469-482 - 2015
Éric Rosenthal, P. Cacoub
Patients with chronic hepatitis C virus (HCV) infection frequently present with extrahepatic manifestations covering a large spectrum, involving different organ systems leading to the concept of systemic HCV infection. These manifestations include autoimmune phenomena and frank autoimmune and/or rheumatic diseases and may dominate the course of chronic HCV infection. Chronic HCV infection...... hiện toàn bộ
Annular erythema in primary Sjögren’s syndrome: description of 43 non-Asian cases
Lupus - Tập 23 Số 2 - Trang 166-175 - 2014
Pilar Brito‐Zerón, Soledad Retamozo, Miriam Akasbi, Myriam Gandía, M. Pérez-de-Lis, M.J. Soto Cárdenas, Cándido Díaz‐Lagares, Belchin Kostov, Albert Selva-O’Callaghan, Xavier Bosch, R. Pérez-Álvarez, Antoni Xaubet, Manuel Ramos‐Casals
Objective The objective of this paper is to evaluate the prevalence and characterize the main epidemiological, clinical and immunological features of annular erythema (AE) in non-Asian patients with primary Sjögren’s syndrome (SS). Methods We carried out a retrospective study searching for AE ...... hiện toàn bộ
Primary antithrombotic prevention in carriers of antiphospholipid antibodies without systemic autoimmune disorders
Lupus - Tập 21 Số 7 - Trang 747-750 - 2012
Guido Finazzi
Primary antithrombotic prevention with aspirin is not indicated in asymptomatic patients with confirmed antiphospholipid (aPL) positivity without systemic autoimmune disorders because: a) the estimated prevalence of thrombosis in unselected cases is about 1% patient-years (range 0–2.8); b) this level of thrombotic risk is equivalent to that of major bleeding associated with the use of asp...... hiện toàn bộ
Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
Lupus - Tập 9 Số 9 - Trang 664-671 - 2000
Mattias Collin, Gunnar Sturfelt, L Truedsson, Jonas Blomberg, Gunnar V. Alm, Helena Vallin, L Rönnblom
The objective was to investigate the relation between serum levels of interferon-α (IFN-α), the activity of an endogenous IFN-a inducing factor (SLE-IIF), clinical and immunological disease activity as well as serum levels of antiretroviral antibodies in SLE. Serum levels of IFN-α were measured in serial sera from 30 patients sampled at different stages of disease activity (SLEDAI score)....... hiện toàn bộ
Factors associated with chloroquine-induced retinopathy in rheumatic diseases
Lupus - Tập 13 Số 2 - Trang 119-124 - 2004
Rodolfo Araiza-Casillas, Maria Cardenas, Y Morales, Mario H. Cardiel
Antimalarials are very useful drugs in the treatment of various rheumatic diseases. One of their main side effects is ocular toxicity, specifically retinopathy. Our objective was to identify risk factors associated with chloroquine retinopathy. A single, trained evaluator reviewed patient records with rheumatic diseases. They were taking chloroquine and identified by the ophthalmologydepa...... hiện toàn bộ
Myocardial tissue characterization in systemic lupus erythematosus: value of a comprehensive cardiovascular magnetic resonance approach
Lupus - Tập 17 Số 6 - Trang 561-567 - 2008
Hassan Abdel‐Aty, N Siegle, Alexander Natusch, Erika Gromnica‐Ihle, Ralf Waßmuth, Rainer Dietz, Jeanette Schulz‐Menger
Systemic lupus erythematosus (SLE) is a multi-organ inflammatory disorder mainly affecting women and is associated with high cardiovascular morbidity and mortality. We tested the utility of a comprehensive cardiovascular magnetic resonance approach to assess myocardial involvement and to determine its relation to disease activity in SLE patients. We studied 20 SLE patients (19 females, 35...... hiện toàn bộ
Acute lupus myocarditis: Clinical features and outcome
Lupus - Tập 20 Số 9 - Trang 981-988 - 2011
Simone Appenzeller, CA Pineau, AE Clarke
Background: Cardiomyopathy in systemic lupus erythematosus (SLE) may be secondary to myocardial inflammation (i.e. myocarditis) or to systemic complications such as hypertension. Symptomatic left ventricular dysfunction is the most common clinical presentation of cardiomyopathy and is potentially life threatening. Identifying the cause is critical as it dictates therapy. ...... hiện toàn bộ
Cardiac involvement in small and medium-sized vessel vasculitides
Lupus - Tập 14 Số 9 - Trang 718-722 - 2005
Christian Lavigne, Loı̈c Guillevin
The heart can be involved in vasculitides but the frequency of its involvement and the manifestations vary according to the vasculitis. Cardiovascular manifestations include cardiomyopathy (specific or resulting from myocardial infarctions), coronary arteritis (with risk of aneurysms, stenoses and thrombosis formation or rupture), pericarditis, valvulitis, conduction-tissue involvement (w...... hiện toàn bộ
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