Lupus

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Prolactin and systemic lupus erythematosus: prolactin secretion by SLE lymphocytes and proliferative (autocrine) activity
Lupus - Tập 4 Số 5 - Trang 348-352 - 1995
Marco A. Gutiérrez, JF Molina, LJ Jara, M L Cuéllar, C. García, Sergio Gutiérrez‐Ureña, A E Gharavi, LR Espinoza
Accumulated evidence suggests that prolactin (PRL) is an important immunoregulator and might have a role in the pathogenesis of systemic lupus erythematosus (SLE). Moreover, a PRL-like molecule is secreted by normal human lymphocytes and acts as an autocrine growth factor for lymphoproliferation. The objective of this study was to explore the PRL-like peptide production by peripheral blood mononuc... hiện toàn bộ
Clinical significance of serum and urine prolactin levels in lupus glomerulonephritis
Lupus - Tập 7 Số 6 - Trang 387-391 - 1998
J M Miranda, Rodrigo Prieto, Ramón Paniagua, Gloria García, Dante Amato, Leonor Barile, Luis J. Jara
Prolactin (PRL) has been involved in the pathogenesis of systemic lupus erythematosus (SLE) and hyperprolactinemia has been connected with systemic activity. However, the clinical significance of PRL has not been investigated in lupus glomerulonephritis (GN). Methods: We studied SLE patients (ACR criteria) with biopsy-proven renal disease. Renal histology was classified according to World Health O... hiện toàn bộ
Risk of developing antiphospholipid antibodies following viral infection: a systematic review and meta-analysis
Lupus - Tập 27 Số 4 - Trang 572-583 - 2018
Noha Abdel‐Wahab, Saurabh Talathi, María A. López-Olivo, María E. Suárez-Almazor
Objective The objective of this paper is to conduct a systematic review and meta-analysis on the risk of developing elevated antiphospholipid (aPL) antibodies and related thromboembolic and/or pregnancy events following a viral infection. Method We searched Medline, EMBASE, Web of Science, PubMed ePubs, and Cochrane Central Register of Controlled Trials through June 2016. Independent observational... hiện toàn bộ
Systematic review of case reports of antiphospholipid syndrome following infection
Lupus - Tập 25 Số 14 - Trang 1520-1531 - 2016
Noha Abdel‐Wahab, María A. López-Olivo, Gineth Paola Pinto-Patarroyo, María E. Suárez-Almazor
Objective The objective of this study was to conduct a systematic review of case reports documenting the development of antiphospholipid syndrome or antiphospholipid syndrome-related features after an infection. Methods We searched Medline, EMBASE, Web of Science, PubMed ePubs, and The Cochrane Library – CENTRAL through March 2015 without restrictions. Studies reporting cases of antiphospholipid s... hiện toàn bộ
Thrombomodulin: An overview and potential implications in vascular disorders
Lupus - Tập 7 Số 2_suppl - Trang 120-125 - 1998
Marie‐Claire Boffa, Marina Karmochkine
Thrombomodulin (TM), a high affinity thrombin receptor present on endothelial cell membrane, plays an important role as a natural anticoagulant. It acts as a cofactor of thrombin-catalyzed activation of protein C, and inhibits the procoagulant functions of thrombin. TM is also located in other cells (keratinocytes, osteoblasts, macrophages, …) where it might be involved in cell differentiation or ... hiện toàn bộ
Severe refractory thrombocytopenia in a woman positive for coronavirus disease 2019 with lupus and antiphospholipid syndrome
Lupus - Tập 29 Số 11 - Trang 1472-1474 - 2020
Alina Hayden, Aishwarya Vyas-Lahar, Vincent Rella, Alla Rudinskaya
The coronavirus disease 2019 (COVID-19) pandemic has created new challenges that necessitate prompt responses in unexpected clinical situations. Multiple extrapulmonary manifestations and complications of COVID-19 have already been described, but only scattered data are present on immunologic manifestations. We present a case of severe refractory thrombocytopenia in a 51-year-old woman with a hist... hiện toàn bộ
A putative regulatory polymorphism in PD-1 is associated with nephropathy in a population-based cohort of systemic lupus erythematosus patients
Lupus - Tập 13 Số 7 - Trang 510-516 - 2004
Christian Nielsen, Michelle Petri, Anne Voss, Peter Junker, Steffen Husby, Søren Thue Lillevang
Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus
Lupus - Tập 17 Số 6 - Trang 568-574 - 2008
Mitsuteru Akahoshi, Hitoshi Nakashima, Atsushi Sadanaga, Katsuhisa Miyake, Kazuhiko Obara, Mayumi Tamari, Tomomitsu Hirota, Akira Matsuda, Taro Shirakawa
In order to identify a novel candidate gene in systemic lupus erythematosus (SLE), we analysed a panel of six genes encoding molecules involved in the type I interferon (IFN) system. We first identified variants in the five genes related to type I IFN pathway by sequencing. Genotyping of a panel of eight selected single-nucleotide polymorphisms (SNPs) in six candidate genes ( TLR9, MYD88, IRF3, IR... hiện toàn bộ
Hematopoietic stem cell transplant for systemic lupus erythematosus: Interferon regulatory factor 7 activation correlates with the IFN signature and recurrent disease
Lupus - Tập 20 Số 9 - Trang 975-980 - 2011
SE Sweeney
The expression and activation of regulatory factors (IRF) and rinterferon (IFN) response genes were evaluated in a patient treated with autologous hematopoietic stem cell transplant (HSCT) for refractory systemic lupus erythematosus (SLE). In SLE patients, genetic variants of IRF5 and IRF7 have been associated with increased serum IFNα levels, suggesting a pathogenic role in the type I IFN respons... hiện toàn bộ
Extrahepatic manifestations in chronic hepatitis C virus carriers
Lupus - Tập 24 Số 4-5 - Trang 469-482 - 2015
Éric Rosenthal, P. Cacoub
Patients with chronic hepatitis C virus (HCV) infection frequently present with extrahepatic manifestations covering a large spectrum, involving different organ systems leading to the concept of systemic HCV infection. These manifestations include autoimmune phenomena and frank autoimmune and/or rheumatic diseases and may dominate the course of chronic HCV infection. Chronic HCV infection causes l... hiện toàn bộ
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