Clinical significance of serum and urine prolactin levels in lupus glomerulonephritis

Lupus - Tập 7 Số 6 - Trang 387-391 - 1998
J M Miranda, Rodrigo Prieto1, Ramón Paniagua, Gloria García, Dante Amato2, Leonor Barile, Luis J. Jara1
1Rheumatology Department, Centro Meádico Nacional La Raza
2Unidad de Investigacioán en Enfermedades Nefrológicas, Instituto Mexicano del Seguro Social, Mexico City, Mexico

Tóm tắt

Prolactin (PRL) has been involved in the pathogenesis of systemic lupus erythematosus (SLE) and hyperprolactinemia has been connected with systemic activity. However, the clinical significance of PRL has not been investigated in lupus glomerulonephritis (GN). Methods: We studied SLE patients (ACR criteria) with biopsy-proven renal disease. Renal histology was classified according to World Health Organization (WHO) criteria. Renal function tests, albuminuria, complement levels (nephelometry), anti-DNA antibodies (C. luciliae) and serum and urine PRL concentrations (RIA) were determined at baseline and at 4-month intervals for one year. Renal activity was defined as mild, moderate or severe according to serum creatinine, creatinine clearance, albuminuria, red blood cells (RBC), and casts. Results: There were 26 patients with mean age 28.5 y and mean disease duration 47.9 months. Twenty patients had diffuse proliferative glomerulonephritis (GN), four had focal GN and two had membranous GN with proliferative changes. Renal activity was mild in ten patients, moderate in ten and severe in six. Mean serum (24.7 5.3) and urine (0.90 0.36) PRL levels were higher in patients with severe renal activity (P < 0.05 compared with mild group). PRL levels decreased after treatment, but this trend was not uniform during the follow-up period. Conclusion: Hyperprolactinemia was prevalent in SLE patients and high levels of PRL in the serum and urine could be related to severe renal disease.

Từ khóa


Tài liệu tham khảo

Besedosvsky HO, 1996, Endocr Rev, 64

Berczi Y , Nagy E . The effect of prolactin and growth hormone on hemolymphopoietic tissue and immune function. In: Berczi Y , Kovacs K (eds) Hormones and immunity MTP Press: Lancaster 1987; p 145-145.

10.1111/j.1600-0897.1991.tb00708.x

10.1177/096120339500400102

Jara-Quezada L, 1991, J Rheumatol, 18, 349

10.1097/00000441-199204000-00003

Neidhart M, 1996, J Rheumatol, 23, 476

Buskila D, 1996, J Rheumatolo, 23, 269

Pauzner R, 1994, J Rheumatol, 21, 2064

McMurray R, 1991, J Immunol, 147, 3780

10.1006/clin.1994.1095

Russel DH, 1985, J Immunol, 134, 3027

10.1016/0167-5699(93)90165-H

Larrea F, 1997, J Clin Endocrinol Metabol, 82, 3664

10.1002/art.1780251101

Appel GB, 1983, Medicine, 75, 382, 10.1016/0002-9343(83)90338-8

10.1016/0002-9343(83)90338-8

Iwano M, 1993, Clin Nephrology, 40, 16

10.1016/0162-3109(87)90004-X

McMurray RW, 1991, Clin Res, 39, 734

10.1159/000237242

10.1177/096120339500400504

10.1007/BF01452255

Thông tin
Thông tin xuất bản

Lupus

Tập 7 Số 6

387-391

Thông tin tác giả