Cardiac magnetic resonance imaging abnormalities in systemic lupus erythematosus: a preliminary report

Lupus - Tập 14 Số 2 - Trang 137-144 - 2005
Jasvinder A. Singh1, Pamela K. Woodard2, Víctor G. Dávila‐Román3, Alan D. Waggoner3, Fernando R. Gutiérrez2, Jie Zheng2, Seth A. Eisen4
1Rheumatology Division, Washington University School of Medicine and St Louis VA Medical Center, St Louis, MO, USA, Rheumatology Division, Minneapolis VA Medical center and University of Minnesota, Minneapolis, MN, USA,
2Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO. USA
3Cardiovascular Division, Department of Medicine, the Cardiovascular Imaging and Clinical Research Core Laboratory, Washington University School of Medicine, St Louis, MO, USA
4Rheumatology Division, Washington University School of Medicine and St Louis VA Medical Center, St Louis, MO, USA

Tóm tắt

The purpose of this prospective, pilot study was to determine whether differences in myocardial T2 relaxivity can be identified among active systemic lupus erythematosus (SLE) patients with clinically suspected SLE myocarditis, other active SLE patients, inactive SLE patients and age and gender matched controls. Eleven consecutive female patients (six with active SLE and five with inactive SLE), and five age, gender and race matched healthy controls underwent imaging with echocardiography and cardiac magnetic resonance imaging (MRI). Echocardiographic measurements included left ventricular end diastolic (LVEDV) and end systolic volumes (LVESV), and mass (LVM) (all indexed to body mass); ejection fraction and cardiac output. The cardiac MRI measurement was the T2 relaxation time (an index of soft tissue signal, with higher levels suggestive of increased tissue water content). Patients with active SLE had significantly higher LVEDVand LVM than inactive SLE patients and healthy controls, and significantly larger LVESV than healthy controls. Myocardial T2 relaxation times were significantly higher in patients with active SLE compared to those with inactive SLE and to healthy controls, and remained higher even after excluding the two active SLE patients who had clinical myocarditis. The four active SLE patients who underwent repeat cardiac imaging studies after clinical improvement showed normalization of these myocardial abnormalities. The conclusion was that active SLE patients demonstrate abnormalities in myocardial structure manifested by high myocardial T2 relaxation times that normalized after clinical improvement in disease activity. These findings suggest that T2 relaxation values are a sensitive indicator of myocardial disease in patients with SLE and that myocardial T2 relaxation abnormality frequently occur in patients with active SLE, even in the absence of myocardial involvement by clinical criteria.

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Tài liệu tham khảo

10.1001/jama.1964.03070150014003

10.1016/0002-9149(90)90329-Y

10.1161/01.CIR.70.1.58

Yamada T, 1997, Jpn Circ J, 61, 827, 10.1253/jcj.61.827

Fairfax MJ, 1988, J Rheumatol, 15, 593

10.1378/chest.122.5.1638

10.1161/01.CIR.97.18.1802

Mahrholdt H, 2003, Circulation, 108, 517

10.1093/cvr/27.8.1462

10.1002/art.1780251101

10.1002/art.1780350606

10.1002/anr.1780320909

Abrahamowicz M, 1998, J Rheumatol, 25, 277

10.1056/NEJM198504043121404

10.1016/S0894-7317(89)80014-8

10.1067/mje.2002.120202

Haacke EM BR , Thompson MR , Venkatesan R. Quantification methods in MR imaging, Chapter 22. Magnetic resonance imaging: physical principles and sequence design. John-Wiley and Sons: New York , 1999: 637-665.

Haacke EM , Brown RW , Thompson MR , Venkatesan R. Signal, contrast and noise, Chapter 15. Magnetic resonance imaging: physical principles and sequence design. John-Wiley and Sons: New York , 1999: 331-378.

10.1097/00004728-200209000-00017

10.1053/crad.2000.0519

10.1111/j.1540-8175.1998.tb00608.x

10.1093/oxfordjournals.eurheartj.a062437

10.1016/S0002-9343(02)01223-8

10.1007/BF02668645

10.1016/S0735-1097(00)01196-7

10.1161/hc3501.096798

10.1161/01.CIR.0000078641.19365.4C

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Lupus

Tập 14 Số 2

137-144

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