Journal of the Association for Research in Otolaryngology
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Polygenic Risk Score-Based Association Analysis of Speech-in-Noise and Hearing Threshold Measures in Healthy Young Adults with Self-reported Normal Hearing
Journal of the Association for Research in Otolaryngology - Tập 24 - Trang 513-525 - 2023
Speech-in-noise (SIN) traits exhibit high inter-subject variability, even for healthy young adults reporting normal hearing. Emerging evidence suggests that genetic variability could influence inter-subject variability in SIN traits. Genome-wide association studies (GWAS) have uncovered the polygenic architecture of various adult-onset complex human conditions. Polygenic risk scores (PRS) summariz......
Knock-in Mouse Model for Resistance to Thyroid Hormone (RTH): An RTH Mutation in the Thyroid Hormone Receptor Beta Gene Disrupts Cochlear Morphogenesis
Journal of the Association for Research in Otolaryngology - - 2002
Thyroid hormone and the beta isoform of its receptor, Trb, are essential for normal development of the mammalian auditory system. We have analyzed auditory system function and structure in a mouse strain with a targeted Thrb mutation, ThrbPV, which leads to the loss of binding of thyroid hormone (T3) to the Trb protein. Heterozygosity for the orthologous human THRBPV mutation and other similar mut......
Review and Perspective on Brain Bases of Tinnitus
Journal of the Association for Research in Otolaryngology - - Trang 1-14 - 2023
In advancing our understanding of tinnitus, some of the more impactful contributions in the past two decades have come from human brain imaging studies, specifically the idea of both auditory and extra-auditory neural networks that mediate tinnitus. These networks subserve both the perception of tinnitus and the psychological reaction to chronic, continuous tinnitus. In this article, we review par......
Towards a Mechanistic-Driven Precision Medicine Approach for Tinnitus
Journal of the Association for Research in Otolaryngology - Tập 20 - Trang 115-131 - 2019
In this position review, we propose to establish a path for replacing the empirical classification of tinnitus with a taxonomy from precision medicine. The goal of a classification system is to understand the inherent heterogeneity of individuals experiencing and suffering from tinnitus and to identify what differentiates potential subgroups. Identification of different patient subgroups with dist......
Hearing in Fishes under Noise Conditions
Journal of the Association for Research in Otolaryngology - Tập 6 - Trang 28-36 - 2005
Our current knowledge on sound detection in fishes is mainly based on data acquired under quiet laboratory conditions. However, it is important to relate auditory thresholds to background noise in order to determine the signal-detecting abilities of animals in the natural environment. We investigated the influence of two noise levels within the naturally occurring range on the auditory sensitivity......
The Effects of Congenital Deafness on Auditory Nerve Synapses: Type I and Type II Multipolar Cells in the Anteroventral Cochlear Nucleus of Cats
Journal of the Association for Research in Otolaryngology - Tập 3 - Trang 403-417 - 2002
Sensory deprivation has been shown to exert detrimental effects on the structure and function of central sensory systems. Congenital deafness represents an extreme form of auditory deprivation, and in the adult white cat, synapses between auditory nerve endings and resident cells of the anteroventral cochlear nucleus exhibited abnormal structure. Endbulbs of Held were reduced in branching and disp......
The Effect of Flying and Low Humidity on the Admittance of the Tympanic Membrane and Middle Ear System
Journal of the Association for Research in Otolaryngology - Tập 14 - Trang 623-633 - 2013
Many passengers experience discomfort during flight because of the effect of low humidity on the skin, eyes, throat, and nose. In this physiological study, we have investigated whether flight and low humidity also affect the tympanic membrane. From previous studies, a decrease in admittance of the tympanic membrane through drying might be expected to affect the buffering capacity of the middle ear......
Behavioral Estimates of the Contribution of Inner and Outer Hair Cell Dysfunction to Individualized Audiometric Loss
Journal of the Association for Research in Otolaryngology - Tập 13 Số 4 - Trang 485-504 - 2012
Individual Differences in Behavioral Estimates of Cochlear Nonlinearities
Journal of the Association for Research in Otolaryngology - Tập 13 - Trang 91-108 - 2011
Psychophysical methods provide a mechanism to infer the characteristics of basilar membrane responses in humans that cannot be directly measured. Because these behavioral measures are indirect, the interpretation of results depends on several underlying assumptions. Ongoing uncertainty about the suitability of these assumptions and the most appropriate measurement and compression estimation proced......
#Otorhinolaryngology #Neurosciences #Neurobiology
Rapid Increase in Neural Conduction Time in the Adult Human Auditory Brainstem Following Sudden Unilateral Deafness
Journal of the Association for Research in Otolaryngology - - 2015
Individuals with sudden unilateral deafness offer a unique opportunity to study plasticity of the binaural auditory system in adult humans. Stimulation of the intact ear results in increased activity in the auditory cortex. However, there are no reports of changes at sub-cortical levels in humans. Therefore, the aim of the present study was to investigate changes in sub-cortical activity immediate......
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