Journal of Zhejiang University-SCIENCE B
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Comparison of pharmacokinetics, efficacy and toxicity profile of gemcitabine using two different administration regimens in Chinese patients with non-small-cell lung cancer
Journal of Zhejiang University-SCIENCE B - Tập 8 - Trang 307-313 - 2007
To conduct a randomized comparative trial of pharmacokinetics, efficacy and toxicity profile treatment with 1200 mg/m2 gemcitabine using standard 30-min infusion or fixed dose rate (FDR) infusion [10 mg/(m2·min)] on days 1 and 8 plus carboplatin AUC (area under curve) 5 on day 1 in Chinese non-small-cell cancer patients. Twelve patients were enrolled in this study. Plasma gemcitabine concentration......
Organ preconditioning: the past, current status, and related lung studies
Journal of Zhejiang University-SCIENCE B - Tập 7 - Trang 331-341 - 2006
Preconditioning (PC) has emerged as a powerful method for experimentally and clinically attenuating various types of organ injuries. In this paper related clinical and basic research issues on organ preconditioning issues were systemically reviewed. Since lung injuries, including ischemia-reperfusion and others, play important roles in many clinical results, including thromboembolism, trauma, ther......
Use of 3-D magnetic resonance electrical impedance tomography in detecting human cerebral stroke: a simulation study
Journal of Zhejiang University-SCIENCE B - Tập 6 - Trang 438-445 - 2005
We have developed a new three dimensional (3-D) conductivity imaging approach and have used it to detect human brain conductivity changes corresponding to acute cerebral stroke. The proposed Magnetic Resonance Electrical Impedance Tomography (MREIT) approach is based on the J-Substitution algorithm and is expanded to imaging 3-D subject conductivity distribution changes. Computer simulation studie......
Spinal P2X7R contributes to streptozotocin-induced mechanical allodynia in mice
Journal of Zhejiang University-SCIENCE B - Tập 21 - Trang 155-165 - 2020
Painful diabetic neuropathy (PDN) is a diabetes mellitus complication. Unfortunately, the mechanisms underlying PDN are still poorly understood. Adenosine triphosphate (ATP)-gated P2X7 receptor (P2X7R) plays a pivotal role in non-diabetic neuropathic pain, but little is known about its effects on streptozotocin (STZ)-induced peripheral neuropathy. Here, we explored whether spinal cord P2X7R was co......
Dynamic measurements of serum inhibin B and estradiol: apredictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment
Journal of Zhejiang University-SCIENCE B - Tập 10 - Trang 35-45 - 2009
We dynamically measured serum inhibin B and estradiol in the early stage of hormonal stimulation to predict the ovarian response in in vitro fertilization (IVF) treatment. A total of 57 patients (<40 years of age) who underwent the first cycle of long protocol IVF or introcytoplasmic sperm injection (ICSI) treatment were included. Serum inhibin B, estradiol, follicle stimulating hormone (FSH) and ......
Kinetic analysis of γ-glutamyltransferase reaction process for measuring activity via an integration strategy at low concentrations of γ-glutamyl p-nitroaniline
Journal of Zhejiang University-SCIENCE B - - 2011
At 0.12 mmol/L γ-glutamyl p-nitroaniline (GGPNA), an improved integrated method was developed for kinetic analysis of γ-glutamyltransferase (GGT) reaction process and the integration with the classical initial rate method to measure serum GGT. For the improved integrated method, an integrated rate equation, which used the predictor variable of reaction time and considered inhibitions by both GGPNA......
Simultaneous removal of nitrate and heavy metals by iron metal
Journal of Zhejiang University-SCIENCE B - Tập 6 - Trang 307-310 - 2005
Great attention should be paid now to simultaneously removing common pollutants, especially inorganic pollutants such as nitrate and heavy metals, as individual removal has been investigated extensively. Removing common pollutants simultaneously by iron metal is a very effective alternative method. Near neutral pH, heavy metals, such as copper and nickel, can be removed rapidly by iron metal, whil......
Effects of sevoflurane preconditioning and postconditioning on rat myocardial stunning in ischemic reperfusion injury
Journal of Zhejiang University-SCIENCE B - Tập 11 - Trang 267-274 - 2010
Ischemic preconditioning and postconditioning distinctly attenuate ventricular arrhythmia after ischemia without affecting the severity of myocardial stunning. Therefore, we report the effects of sevoflurane preconditioning and postconditioning on stunned myocardium in isolated rat hearts. Isolated rat hearts were underwent 20 min of global ischemia and 40 min of reperfusion. After an equilibratio......
Joint effects of microwave and chromium trioxide on root tip cells of Vicia faba
Journal of Zhejiang University-SCIENCE B - Tập 7 - Trang 221-227 - 2006
The mutagenic effects of microwave and chromium trioxide (CrO3) on Vicia faba root tip were studied. Micronucleus assay and chromosomal aberration assay were used to determine the mitotic index, the micronucleus frequency and chromosomal aberration frequency of Vicia faba root tip cells induced by microwave and CrO3. The results showed that the micronucleus frequency decreased, and that the mitoti......
Phân tích trực quan về nghiên cứu công nghệ chỉnh sửa gen CRISPR/Cas9 Dịch bởi AI
Journal of Zhejiang University-SCIENCE B - Tập 17 - Trang 798-806 - 2016
Hệ thống lặp lại palindrom ngắn xen kẽ thường xuyên cụm (CRISPR)/Protein liên kết CRISPR 9 (Cas9) là một hệ thống miễn dịch thích ứng chống lại sự xâm nhập của virus và plasmid, vật chất di truyền dị hợp trong vi khuẩn và vi sinh vật cổ. Bằng cách xem xét các tài liệu liên quan đến công nghệ chỉnh sửa gen CRISPR/Cas9 từ cơ sở dữ liệu Web of Science từ năm 2002 đến 2015, chúng tôi sử dụng phần mềm ......
#CRISPR #Cas9 #chỉnh sửa gen #vi sinh vật #miễn dịch thích ứng #phân tích tài liệu
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