Journal of Thrombosis and Thrombolysis
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Thrombelastography does not predict clinical response to rtPA for acute ischemic stroke
Journal of Thrombosis and Thrombolysis - Tập 41 - Trang 505-510 - 2015
Thrombelastography (TEG) measures coagulation in venous blood. We hypothesized that TEG, by reflecting clot subtype and ex vivo fibrinolysis, might predict fibrinolytic response to tPA as reflected by rapid clinical improvement or hemorrhagic transformation of the infarct. 171 acute ischemic stroke patients treated with tPA were prospectively enrolled. Venous blood for TEG was drawn before and 10 ...... hiện toàn bộ
Immature platelets in patients with Covid-19: association with disease severity
Journal of Thrombosis and Thrombolysis - Tập 52 - Trang 708-714 - 2021
Coronavirus disease 2019 (Covid-19) is associated with a high incidence of venous and arterial thromboembolic events. Currently, there are no clinical or laboratory markers that predict thrombotic risk. Circulating immature platelets are hyper-reactive platelets, which are associated with arterial thrombotic events. The aim of this study was to assess whether the proportion of circulating immature...... hiện toàn bộ
Neutrophil extracellular traps and thrombosis in COVID-19
Journal of Thrombosis and Thrombolysis - Tập 51 - Trang 446-453 - 2020
Studies of patients with COVID-19 have demonstrated markedly dysregulated coagulation and a high risk of morbid arterial and venous thrombotic events. Elevated levels of blood neutrophils and neutrophil extracellular traps (NETs) have recently been described in patients with COVID-19. However, their potential role in COVID-19-associated thrombosis remains incompletely understood. In order to eluci...... hiện toàn bộ
Architecture of fibrin network inside thrombotic material obtained from the right atrium and pulmonary arteries: flow and location matter
Journal of Thrombosis and Thrombolysis - Tập 35 Số 1 - Trang 127-129 - 2013
Pulmonary embolectomy is a treatment option in selected patients with high-risk pulmonary embolism (PE). Efficiency of thrombus degradation in PE largely depends on the architecture of its fibrin network, however little is known about its determinants. We present the case of a 56-year-old woman with high-risk PE and proximal deep-vein thrombosis, whose thrombotic material removed during embolectom...... hiện toàn bộ
Impact of antithrombin III and enoxaparin dosage adjustment on prophylactic anti-Xa concentrations in trauma patients at high risk for venous thromboembolism: a randomized pilot trial
Journal of Thrombosis and Thrombolysis - Tập 52 - Trang 1117-1128 - 2021
The impact of antithrombin III activity (AT-III) on prophylactic enoxaparin anti-factor Xa concentration (anti-Xa) is unknown in high-risk trauma patients. So too is the optimal anti-Xa-adjusted enoxaparin dosage. This prospective, randomized, pilot study sought to explore the association between AT-III and anti-Xa goal attainment and to preliminarily evaluate two enoxaparin dosage adjustment stra...... hiện toàn bộ
Therapeutic implication of MicroRNA-320a antagonist in attenuating blood clots formed during venous thrombosis
Journal of Thrombosis and Thrombolysis - - 2024
Venous thrombosis (VT) is a complex multi-factorial disease and a major health concern worldwide. Its clinical implications include deep vein thrombosis (DVT) and pulmonary embolism (PE). VT pathogenesis involves intricate interplay of various coagulants and anti-coagulants. Growing evidences from epidemiological studies have shown that many non-coding microRNAs play significant regulatory role in...... hiện toàn bộ
Đặc điểm và tiên lượng của tắc mạch lớn cấp tính ở tuần hoàn trước và sau sau điều trị داخ mạch: kinh nghiệm thực tiễn từ đăng ký ANGEL Dịch bởi AI
Journal of Thrombosis and Thrombolysis - Tập 49 - Trang 527-532 - 2020
Có rất ít nghiên cứu so sánh đột quỵ thiếu máu cục bộ cấp tính ở tuần hoàn trước (AC) và tuần hoàn sau (PC). Nghiên cứu của chúng tôi nhằm đánh giá các đặc điểm khác biệt của đột quỵ AC và PC liên quan đến các yếu tố lâm sàng, nguy cơ mạch máu, sinh bệnh học và kết quả sau các thủ thuật nội mạch. Nghiên cứu đa trung tâm triển vọng này đã ghi nhận 873 bệnh nhân bị tắc mạch cấp tính lớn ở đột quỵ tu...... hiện toàn bộ
#đột quỵ thiếu máu cục bộ cấp tính #tuần hoàn trước #tuần hoàn sau #thủ thuật nội mạch #sinh bệnh học #tiên lượng
Vascular applications of human gene therapy
Journal of Thrombosis and Thrombolysis - Tập 1 - Trang 299-302 - 1995
Complexing recombinant DNA with cationic liposomes is a convenient means of introducing foreign genes into cells (lipofection) and could potentially form the basis for genetically modifying diseased blood vessels in patients. The mechanism of lipofection is incompletely understood, but it is recognized that the degree of successful gene transfer is highly dependent on cell type. We have transfecte...... hiện toàn bộ
Role of mean platelet volume in triagging acute coronary syndromes
Journal of Thrombosis and Thrombolysis - Tập 26 - Trang 49-54 - 2007
Background: Acute coronary syndromes, characterized by the rupture of unstable plaque and the subsequent thrombotic process involving platelets, have been increasing in relative frequency. The central role of platelet activation has long been noticed in this pathophysiology; hence, many therapies have been directed against it. In this study, we have aimed to search prospectively the value of mean ...... hiện toàn bộ
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