Clinical outcomes after percutaneous coronary intervention for early versus late and very late stent thrombosis: a systematic review and meta-analysis

Journal of Thrombosis and Thrombolysis - Tập 51 - Trang 682-692 - 2020
Yi-Xing Yang1, Yin Liu2, Xiao-Wei Li2, Peng-Ju Lu2, Jiao Wang1, Chang-Ping Li1, Jing Gao3
1Tianjin Medical University, Tianjin, People’s Republic of China
2Department of Cardiology, Tianjin Chest Hospital, Tianjin, People’s Republic of China
3Cardiovascular Institute, Tianjin Chest Hospital, Tianjin, People’s Republic of China

Tóm tắt

Whether the clinical outcomes of stent thrombosis (ST) are different when stratified by time of occurrence remains unclear. The objective of this study was to compare the short- and long-term clinical outcomes after percutaneous coronary intervention (PCI) for early stent thrombosis (EST) versus late stent thrombosis (LST) and very late stent thrombosis (VLST). We enrolled eligible studies searched from the main electronic databases (EMBASE, PubMed, Cochrane). The primary endpoints were in-hospital, 30-day, 1-year and long-term mortality. The secondary endpoints included recurrent stent thrombosis (RST) and target vessel/lesion revascularization (TVR/TLR) during hospitalization, at 30 days, at 1 year and at long-term follow-up. A total of 23 studies with 17,592 patients were included. Compared with mortality rates of the late and very late thrombosis (LST/VLST) group, in-hospital (P = 0.004), 30-day (P < 0.00001), 1-year (P < 0.00001) and long-term mortality rates (P = 0.04) were significantly higher in the EST group. The in-hospital TVR/TLR rates were similar between the EST group and the LST/VLST group. However, a higher trend in TVR/TLR rate at 30 days and a significantly higher TVR/TLR rate at 1 year (P = 0.002) as well as at long-term follow up (P = 0.009) were found in the EST group. EST patients also trended toward higher risk of RST in both short- and long-term follow-up than LST/VLST patients, although differences were not statistically significant. After PCI treatment, patients with EST have worse clinical outcomes in both short- and long-term follow-up than patients with LST/VLST. Further studies are warranted to determine the optimal treatment strategies for EST.

Tài liệu tham khảo

Iqbal J, Sumaya W, Tatman V et al (2013) Incidence and predictors of stent thrombosis: a single-centre study of 5,833 consecutive patients undergoing coronary artery stenting. EuroIntervention 9:62–69 Rozemeijer R, Wing WC, Leenders G et al (2019) Incidence, angiographic and clinical predictors, and impact of stent thrombosis: a 6-year survey of 6,545 consecutive patients. Neth Heart J 27:321–329 Cutlip DE, Windecker S, Mehran R et al (2007) Clinical end points in coronary stent trials: a case for standardized definitions. Circulation 115:2344–2351 Lemesle G, De Labriolle A, Bonello L et al (2009) Clinical manifestation and prognosis of early versus late stent thrombosis of drug-eluting stents. J Interv Cardiol 22:228–233 Margolis G, Barkagan M, Flint N et al (2016) Prevalence and outcomes of early versus late stent thrombosis presenting as ST-segment elevation myocardial infarction. Coron Artery Dis 27:667–672 Jones DA, Gallagher S, Rathod KS et al (2013) Contemporary analysis of incidence and outcomes of stent thrombosis presenting as ST elevation myocardial infarction in a primary percutaneous coronary intervention cohort. Am J Cardiol 112:1347–1354 Kimura T, Morimoto T, Kozuma K et al (2010) Comparisons of baseline demographics, clinical presentation, and long-term outcome among patients with early, late, and very late stent thrombosis of sirolimus-eluting stents: Observations from the Registry of Stent Thrombosis for Review and Reevaluation (RESTART). Circulation 122:52–61 Kubo S, Kadota K, Ichinohe T et al (2014) Comparison of long-term outcome after percutaneous coronary intervention for stent thrombosis between early, late, and very late stent thrombosis. Circ J 78:101–109 Armstrong EJ, Feldman DN, Wang TY et al (2012) Clinical presentation, management, and outcomes of angiographically documented early, late, and very late stent thrombosis. JACC Cardiovasc Interv 5:131–140 de la Torre-Hernández JM, Alfonso F, Hernández F et al (2008) Drug-eluting stent thrombosis: results from the multicenter Spanish registry ESTROFA (Estudio ESpañol sobre TROmbosis de stents FArmacoactivos). J Am Coll Cardiol 51:986–990 Daemen J, Wenaweser P, Tsuchida K et al (2007) Early and late coronary stent thrombosis of sirolimus-eluting and paclitaxel-eluting stents in routine clinical practice: data from a large two-institutional cohort study. Lancet 369:667–678 Singh B, Ramesh B, Rajendran R et al (2018) Incidence, predictors, and long term clinical outcome of angiographic definite stent thrombosis in real world scenario - A prospective cohort study. Cardiovasc Revasc Med 19:666–670 Kuramitsu S, Ohya M, Shinozaki T et al (2019) Risk factors and long-term clinical outcomes of second-generation drug-eluting stent thrombosis. Circ Cardiovasc Interv 12:e007822 Mahmoud KD, Vlaar PJ, van den Heuvel AF et al (2011) Usefulness of thrombus aspiration for the treatment of coronary stent thrombosis. Am J Cardiol 108:1721–1727 Lempereur M, Bogale N, Fahmy P et al (2016) Clinical characteristics, angiographic findings, and one-year outcome of 101 consecutive stent thrombosis cases in British Columbia. Cardiovasc Revasc Med 17:74–80 Kim MC, Kim IS, Jeong MH et al (2019) Incidence of cardiac death and recurrent stent thrombosis after treatment for angiographically confirmed stent thrombosis. J Cardiol 74:267–272 Armstrong EJ, Maddox TM, Carey EP et al (2014) Mortality after presentation with stent thrombosis is associated with time from index percutaneous coronary intervention: a report from the VA CART program. Am Heart J 168:560–567 Almalla M, Schröder J, Hennings V et al (2013) Long-term outcome after angiographically proven coronary stent thrombosis. Am J Cardiol 11:1289–1294 van Werkum JW, Heestermans AA, de Korte FI et al (2009) Long-term clinical outcome after a first angiographically confirmed coronary stent thrombosis: an analysis of 431 cases. Circulation 119:828–834 Katsikis A, Keeble TR, Davies JR et al (2019) Contemporary management of stent thrombosis: Predictors of mortality and the role of new-generation drug-eluting stents. Catheter Cardiovasc Interv. https://doi.org/10.1002/ccd.28467 Yeo KK, Armstrong EJ, Soni K et al (2015) Long-term outcomes of angiographically confirmed coronary stent thrombosis: results from a multicentre California registry. EuroIntervention 11:188–195 Konishi A, Mitsutake Y, Ho M et al (2019) Patient and lesion characteristics in late/very late stent thrombosis with everolimus-eluting stents from real-world adverse event reporting. J Cardiol. https://doi.org/10.1016/j.jjcc.2019.07.016 Tovar FMN, Zanchin T, Masdjedi K et al (2019) Incidence and predictors of outcomes after a first definite coronary stent thrombosis. EuroIntervention. https://doi.org/10.4244/EIJ-D-19-00219 Feldman DN, Armstrong EJ, Wang TY et al (2011) Presentation treatment and outcomes of early late and very late stent thrombosis: a report from the american college of cardiology National Cardiovascular Data Registry. J Am Coll Cardiol 57:E1103 Shimotakahara J, Yamaji K, Iwabuchi M et al (2013) Long-term outcomes in patients with early, late and very late stent thrombosis after bare metal stenting. Eur Heart J 34:4897–4897 Kukreja N, Onuma Y, Garcia-Garcia HM et al (2009) The Risk of Stent Thrombosis in Patients With Acute Coronary Syndromes Treated With Bare-Metal and Drug-Eluting Stents. JACC Cardiovasc Interv 2:534–541 The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses (2016) https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 4 Mar 2016. van Werkum JW, Heestermans AA, Zomer AC et al (2009) Predictors of Coronary Stent Thrombosis: The Dutch Stent Thrombosis Registry. J Am Coll Cardiol 53:1399–1409 Aissaoui N, Puymirat E, Delmas C et al (2020) Trends in cardiogenic shock complicating acute myocardial infarction. EUR J HEART FAIL 22:664–672 Ong DS, Jang IK (2015) Causes, assessment, and treatment of stent thrombosis–intravascular imaging insights. Nat Rev Cardiol 12:325–336 Adriaenssens T, Joner M, Godschalk TC et al (2017) Optical Coherence Tomography Findings in Patients With Coronary Stent Thrombosis: A Report of the PRESTIGE Consortium (Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort). Circulation 136:1007–1021 Parodi G, La Manna A, Di VL et al (2013) Stent-related defects in patients presenting with stent thrombosis: differences at optical coherence tomography between subacute and late/very late thrombosis in the Mechanism of Stent Thrombosis (MOST) study. EuroIntervention 9:936–944 Souteyrand G, Amabile N, Mangin L et al (2016) Mechanisms of stent thrombosis analysed by optical coherence tomography: insights from the national PESTO French registry. Eur Heart J 37:1208–1216 Chechi T, Vecchio S, Vittori G et al (2008) ST-segment elevation myocardial infarction due to early and late stent thrombosis. A new group of high-risk patients. J Am Coll Cardiol 51:2396–2402 Sianos G, Papafaklis MI, Daemen J et al (2007) Angiographic stent thrombosis after routine use of drug-eluting stents in ST-segment elevation myocardial infarction: the importance of thrombus burden. J Am Coll Cardiol 50:573–583 Cui K, Lyu S, Song X et al (2018) Effect of coronary collaterals on prognosis in patients undergoing primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction: a meta-analysis. Angiology 69:803–811 Freund A, Stiermaier T, de Waha-Thiele S et al (2020) Coronary collaterals in patients with ST-elevation myocardial infarction presenting late after symptom onset. Clin Res Cardiol. https://doi.org/10.1007/s00392-020-01625-w Geisler T, Zurn C, Simonenko R et al (2010) Early but not late stent thrombosis is influenced by residual platelet aggregation in patients undergoing coronary interventions. Eur Heart J 31:59–66 Carrick D, Oldroyd KG, McEntegart M et al (2014) A randomized trial of deferred stenting versus immediate stenting to prevent no- or slow-reflow in acute ST-segment elevation myocardial infarction (DEFER-STEMI). J Am Coll Cardiol 63:2088–2098 Sun B, Liu J, Yin H et al (2019) Delayed vs. immediate stenting in STEMI with a high thrombus burden: a systematic review and meta-analysis. Herz 44:726–734 Mahtta D, Mahmoud AN, Mojadidi MK et al (2018) Intravascular ultrasound–guided percutaneous coronary intervention: an updated review. Cardiovasc Innov Appl. https://doi.org/10.15212/CVIA.2017.0029 Kubo T, Imanishi T, Takarada S et al (2007) Assessment of culprit lesion morphology in acute myocardial infarction: ability of optical coherence tomography compared with intravascular ultrasound and coronary angioscopy. J Am Coll Cardiol 50:933–939