Glucose and glutamine metabolism control by APC and SCF during the G1-to-S phase transition of the cell cycleJournal of Physiology and Biochemistry - Tập 70 - Trang 569-581 - 2014
Irving Omar Estévez-García, Verónica Cordoba-Gonzalez, Eleazar Lara-Padilla, Abel Fuentes-Toledo, Ramcés Falfán-Valencia, Rafael Campos-Rodríguez, Edgar Abarca-Rojano
Recent studies have given us a clue as to how modulations of both metabolic pathways and cyclins by the ubiquitin system influence cell cycle progression. Among these metabolic modulations, an aerobic glycolysis and glutaminolysis represent an initial step for metabolic machinery adaptation. The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintai...... hiện toàn bộ
Interactions between serotoninergic and aminoacidergic pathways in the control of PRL secretion in prepubertal male ratsJournal of Physiology and Biochemistry - Tập 57 Số 3 - Trang 237-244 - 2001
Pinilla, L., González, L. C., Tena-Sempere, M., Aguilar, E.
Prolactin secretion is controlled by the hypothalamus through different neurotransmitters which interact with multiple receptor subtypes. The discovery of different families of receptors for serotonin (5-HT1-5-HT7) and excitatory aminoacids (NMDA,KA,AMPA and metabotropic receptors) ilustrates the complexity of this regulation. Moreover, in the rat the role of different neurotransmitters changes du...... hiện toàn bộ
JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytesJournal of Physiology and Biochemistry - Tập 76 - Trang 655-662 - 2020
Yun Zhao, Suxian Ma, Xingna Hu, Min Feng, Rong Xiang, Min Li, Chenxiao Liu, Ting Lu, Aijie Huang, Jiaqi Chen, Mian Wu, Honghong Lu
Insulin resistance (IR) is the primary pathological mechanism underlying Type 2 diabetes mellitus (T2DM). Many researches have reported the relationship between chronic inflammation and IR, while the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway is rapidly activated in inflammatory conditions. However, the functional role of ERK1/2 in IR remains to be identified. We here reported that...... hiện toàn bộ
Endocrine profiles during doe-litter separation and the subsequent pregnancy in rabbitsJournal of Physiology and Biochemistry - Tập 57 - Trang 23-29 - 2001
E. Ubilla, P. G. Rebollar, D. Pazo, A. Esquifino, J. M. R. Alvariño
This study was carried out to determine the effects of a transient doe-litter separation on plasma prolactin, LH, FSH, estradiol-17β and progesterone concentrations before artificial insemination and during the subsequent pregnancy. Control does (n=12) had free access to nursing, whereas separated does (n=12) were kept away from their litters for 48 hours before artificial insemination. Both group...... hiện toàn bộ
MAO activity in serotonergic endings of rat major cerebral arteriesJournal of Physiology and Biochemistry - Tập 60 - Trang 23-29 - 2004
A. L. López de Pablo, M. Ajubita, M. C. F. Criado, E. J. Marco
The present work studies the existence of monoamine oxidase (MAO) activity in serotonergic endings present in rat major cerebral arteries. Enzymatic activity was appraisedin vivo by serotonin (5-HT) accumulation or 5-hydroxyindole acetic acid (5-HIAA) disappearance with time after systemic administration of MAO inhibitors. Pargyline (75 mg/Kg, i.p.) brought about significant 5-HT increase and 5-HI...... hiện toàn bộ
Knockdown of ASIC2a subunit aggravates injury of rat C6 glioma cells in acidosisJournal of Physiology and Biochemistry - Tập 67 - Trang 275-281 - 2010
Xiao-Yan Liu, Shu-Zhuo Zhang, Xiao-Yun Ma, Hui Wang, Bao-Hong Wu, Hong-Liang Sun, Xin Li, Xiao-Li Wei, Jian-Quan Zheng
Acid-sensing ion channel 1a (ASIC1a) and 2a (ASIC2a) subunits are widely expressed throughout mammalian central nervous system. Activation of Ca2+-permeable ASIC1a homomultimers is largely responsible for acidosis-mediated, glutamate receptor-independent, ischemic neuronal injury. The function of ASIC2a in brain ischemia is less known except that transient global ischemia induces ASIC2a protein ex...... hiện toàn bộ