Baicalin suppresses renal fibrosis through microRNA-124/TLR4/NF-κB axis in streptozotocin-induced diabetic nephropathy mice and high glucose-treated human proximal tubule epithelial cells

Journal of Physiology and Biochemistry - Tập 76 Số 3 - Trang 407-416 - 2020
She-Feng Zhang1, Li Xu2, Ruifeng Liang3, Chenhua Yang3, Peiren Wang4
1Henan Academy of Chinese Medicine, Zhengzhou, 450000, China.
2Henan University of Chinese Medicine, Zhengzhou, China
3Henan Academy of Chinese Medicine, Zhengzhou, China
4The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Ahmad J (2015) Management of diabetic nephropathy: recent progress and future perspective. Diabetes Metab Syndr 9:343–358

Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281–297

Barutta F, Bruno G, Grimaldi S, Gruden G (2015) Inflammation in diabetic nephropathy: moving toward clinical biomarkers and targets for treatment. Endocrine 48:730–742

Butz H, Szabo PM, Khella HW, Nofech-Mozes R, Patocs A, Yousef GM (2015) miRNA-target network reveals miR-124as a key miRNA contributing to clear cell renal cell carcinoma aggressive behaviour by targeting CAV1 and FLOT1. Oncotarget 6:12543–12557

Chen JQ, Szodoray P, Zeher M (2016) Toll-like receptor pathways in autoimmune diseases. Clin Rev Allergy Immunol 50:1–17

Chung AC-K, Lan HY (2015) MicroRNAs in renal fibrosis. Front Physiol 6:50

Dewanjee S, Bhattacharjee N (2018) MicroRNA: a new generation therapeutic target in diabetic nephropathy. Biochem Pharmacol 155:32–47

Garibotto G, Carta A, Picciotto D, Viazzi F, Verzola D (2017) Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy. J Nephrol 30:719–727

Genovese F, Manresa AA, Leeming DJ, Karsdal MA, Boor P (2014) The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis? Fibrogenesis Tissue Repair 7:4

González-Guerrero C, Cannata-Ortiz P, Guerri C, Egido J, Ortiz A, Ramos AM (2017) TLR4-mediated inflammation is a key pathogenic event leading to kidney damage and fibrosis in cyclosporine nephrotoxicity. Arch Toxicol 91:1925–1939

Gülden E, Wen L (2014) Toll-like receptor activation in immunity vs. tolerance in autoimmune diabetes. Front Immunol 5:119

Huang NQ, Jin H, Zhou SY, Shi JS, Jin F (2017) TLR4 is a link between diabetes and Alzheimer’s disease. Behav Brain Res 316:234–244

Ichii O, Horino T (2018) MicroRNAs associated with the development of kidney diseases in humans and animals. J Toxicol Pathol 31:23–34

Jheng HF, Tsai PJ, Chuang YL, Shen YT, Tai TA, Chen WC, Chou CK, Ho LC, Tang MJ, Lai KT, Sung JM, Tsai YS (2015) Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy. Dis Model Mech 8:1311–1321

Jiménez-Dalmaroni MJ, Gerswhin ME, Adamopoulos IE (2016) The critical role of toll-like receptors—from microbial recognition to autoimmunity: a comprehensive review. Autoimmun Rev 15:1–8

Kawai T, Akira S (2007) Signaling to NF-κB by toll-like receptors. Trends Mol Med 13:460–469

Kawasaki T, Kawai T (2014) Toll-like receptor signaling pathways. Front Immunol 5:461

Li D, Lu Z, Jia J, Zheng Z, Lin S (2013a) Curcumin ameliorates Podocytic adhesive capacity damage under mechanical stress by inhibiting miR-124 expression. Kidney Blood Press Res 38:61–71

Li D, Lu Z, Jia J, Zheng Z, Lin S (2013b) MiR-124 is related to podocytic adhesive capacity damage in STZ-induced uninephrectomized diabetic rats. Kidney Blood Press Res 37:422–431

Li XY, Zhang YQ, Xu G, Li SH, Li H (2018) miR-124/MCP-1 signaling pathway modulates the protective effect of itraconazole on acute kidney injury in a mouse model of disseminated candidiasis. Int J Mol Med 41:3468–3476

Liu T, Dai W, Li C, Liu F, Chen Y, Weng D, Chen J (2015) Baicalin alleviates silica-induced lung inflammation and fibrosis by inhibiting the Th17 response in C57BL/6 mice. J Nat Prod 78:3049–3057

Loeffler I, Wolf G (2015) Epithelial-to-mesenchymal transition in diabetic nephropathy: fact or fiction? Cells 4:631–652

Ma J, Chadban SJ, Zhao CY, Chen X, Kwan T, Panchapakesan U, Pollock CA, Wu H (2014) TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy. PLoS One 9:e97985

Magee C, Grieve DJ, Watson CJ, Brazil DP (2017) Diabetic nephropathy: a tangled web to unweave. Cardiovasc Drugs Ther 31:579–592

Meng XM, Nikolic-Paterson DJ, Lan HY (2014) Inflammatory processes in renal fibrosis. Nat Rev Nephrol 10:493–503

Mishra V, Pathak C (2018) Human toll-like receptor 4 (hTLR4): structural and functional dynamics in cancer. Int J Biol Macromol 122:425–451

Nam J, Kim JH, Park K, Lee SB, Nam JS, Park JS, Park SJ, Kim YS, Ahn CW. 2019. 548-P: Baicalin attenuates fibrosis process in human renal proximal tubular cells in hyperglycemic Conditioneditor^editors: am diabetes Assoc.

Peng XD, Dai LL, Huang CQ, He CM, Chen LJ (2009) Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis. World J Gastroenterol: WJG 15:4720–4725

Periyasamy P, Liao K, Kook YH, Niu F, Callen SE, Guo M-L, Buch S (2018) Cocaine-mediated downregulation of miR-124 activates microglia by targeting KLF4 and TLR4 signaling. Mol Neurobiol 55:3196–3210

Sun G-d, Li C-y, Cui W-p, Guo Q-y, Dong C-q, Zou H-b, Liu S-j, Dong W-p, L-n M (2016) Review of herbal traditional Chinese medicine for the treatment of diabetic nephropathy. J Diabetes Res 2016:5749857

Tesch GH (2017) Diabetic nephropathy - is this an immune disorder? Clin Sci (Lond) 131:2183–2199

Vierbuchen T, Stein K, Heine H (2018) RNA is taking its toll - impact of RNA-specific toll-like receptors on health and disease. Allergy 74:223–235

Wada J, Makino H (2016) Innate immunity in diabetes and diabetic nephropathy. Nat Rev Nephrol 12:13–26

Wu X, Ding X, Ding Z, Jia P (2018) Total flavonoids from leaves of Carya Cathayensis ameliorate renal fibrosis via the miR-21/Smad7 signaling pathway. Cell Physiol Biochem 49:1551–1563

Xia J, He LQ, Su X (2016) Interventional mechanisms of herbs or herbal extracts on renal interstitial fibrosis. J Integr Med 14:165–173

Xue M, Cheng Y, Han F, Chang Y, Yang Y, Li X, Chen L, Lu Y, Sun B, Chen L (2018) Triptolide attenuates renal tubular epithelial-mesenchymal transition via the MiR-188-5p-mediated PI3K/AKT pathway in diabetic kidney disease. Int J Biol Sci 14:1545–1557

Zell S, Schmitt R, Witting S, Kreipe HH, Hussein K, Becker JU (2013) Hypoxia induces mesenchymal gene expression in renal tubular epithelial cells: an in vitro model of kidney transplant fibrosis. Nephron Extra 3:50–58

Zhang XP, Tian H, Lai YH, Chen L, Zhang L, Cheng QH, Yan W, Li Y, Li QY, He Q (2007) Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis. World J Gastroenterol: WJG 13:5079–5089

Zhang XT, Wang G, Ye LF, Pu Y, Li RT, Liang J, Wang L, Ka Ho Lee K, Yang X 2018. Protective effects of baicalin on diabetes mellitus-induced renal fibrosis in mice Available at SSRN 3309387

Zheng L, Zhang C, Li L, Hu C, Hu M, Sidikejiang N, Wang X, Lin M, Rong R (2017) Baicalin ameliorates renal fibrosis via inhibition of transforming growth factor β1 production and downstream signal transduction. Mol Med Rep 15:1702–1712

Zhou X, Seto SW, Chang D, Kiat H, Razmovski-Naumovski V, Chan K, Bensoussan A (2016) Synergistic effects of Chinese herbal medicine: a comprehensive review of methodology and current research. Front Pharmacol 7:201

Zhou H, Gao L, Yu ZH, Hong SJ, Zhang ZW, Qiu ZZ (2018) LncRNA HOTAIR promotes renal interstitial fibrosis by regulating Notch1 pathway via the modulation of miR-124. Nephrology (Carlton)