Yong Huang, Xing Jia Shen, Quan Zou, Sheng Peng Wang, Shun Ming Tang, Guo Zheng Zhang
MicroRNAs (miRNAs) are a recently discovered family of endogenous, noncoding RNA
molecules approximately 22 nt in length. miRNAs modulate gene expression
post-transcriptionally by binding to complementary sequences in the coding or 3′
untranslated region of target messenger RNAs (mRNAs). It is now clear that the
biogenesis and function of miRNAs are related to the molecular mechanisms of
various c... hiện toàn bộ
Miroslav Kovarik, Tomas Muthny, Ludek Sispera, Milan Holecek
β-Hydroxy-β-methylbutyrate (HMB) is a leucine metabolite that may have a
positive effect in protein catabolic conditions. Therefore, we hypothesized that
HMB treatment could attenuate the sepsis-induced protein catabolic state. The
aims of our study were to elucidate the effect of HMB in healthy and septic
animals and to evaluate the differences in the action of HMB in different muscle
types. Inta... hiện toàn bộ