Deregulation of NF-кB–miR-146a negative feedback loop may be involved in the pathogenesis of diabetic neuropathy

Alipour MR, Khamaneh AM, Yousefzadeh N, Mohammad-nejad D, Soufi FG (2013) Upregulation of microRNA-146a was not accompanied by downregulation of pro-inflammatory markers in diabetic kidney. Mol Biol Rep 40:6477–6483

Balasubramanyam M, Aravind S, Gokulakrishnan K, Prabu P, Sathishkumar C, Ranjani H, Mohan V (2011) Impaired miR-146a expression links subclinical inflammation and insulin resistance in type 2 diabetes. Mol Cell Biochem 351:197–205

Baltimore D, Boldin MP, O'Connell RM, Rao DS, Taganov KD (2008) MicroRNAs: new regulators of immune cell development and function. Nat Immunol 9:839–945

Boldin M, Taganov K, Rao D, Yang L, Zhao J, Kalwani M, Garcia-Flores Y, Luong M, Devrekanli A, Xu J, Sun G, Tay J, Linsley PS, Baltimore D (2011) MiR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med 208:1189–1201

Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414:813–820

Cheng H, Sivachandran N, Lau A, Boudreau E, Zhao J, Baltimore D, Delgado-Olguin P, Cybulsky MI, Fish JE (2013) MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways. EMBO Mol Med 5:949–966

Chopra K, Tiwari V, Arora V, Kuhad A (2010) Sesamol suppresses neuro-inflammatory cascade in experimental model of diabetic neuropathy. J Pain 11:950–957

Edwards JL, Vincent AM, Cheng HT, Feldman EL (2008) Diabetic neuropathy: mechanisms to management. Pharmacol Ther 120:1–34

Feng B, Chen S, McArthur K, Wu Y, Sen S, Ding Q, Feldman RD, Chakrabarti S (2011) miR-146a-Mediated extracellular matrix protein production in chronic diabetes complications. Diabetes 60:2975–2984

Forbes JM, Cooper ME (2013) Mechanisms of diabetic complications. Physiol Rev 93:137–188

Ganesh Yerra V, Negi G, Sharma SS, Kumar A (2013) Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-kappa B pathways in diabetic neuropathy. Redox Biol 1:394–397

Granic I, Dolga AM, Nijholt IM, van Dijk G, Eisel UL (2009) Inflammation and NF-kappa B in Alzheimer’s disease and diabetes. J Alzheimers Dis 16:809–821

Kaltschmidt B, Kaltschmidt C (2009) NF-kappaB in the nervous system. Cold Spring Harb Perspect Biol 1:a001271

Kamboj SS, Vasishta RK, Sandhir R (2010) N-acetylcysteine inhibits hyperglycemia-induced oxidative stress and apoptosis markers in diabetic neuropathy. J Neurochem 112:77–91

Kumar A, Sharma SS (2010) NF-kappa B inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathy. Biochem Biophys Res Commun 394:360–355

Lovis P, Roggli E, Laybutt DR, Gattesco S, Yang JY, Widmann C, Abderrahmani A, Regazzi R (2008) Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes 57:2728–2736

Ma X, Becker Buscaglia LE, Barker JR, Li Y (2011) MicroRNAs in NF-kappa B signaling. J Mol Cell Biol 3:159–166

Mann DL (2011) The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls. Circ Res 108:1133–1145

Mattson MP, Camandola S (2001) NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest 107:247–254

Meffert MK, Baltimore D (2005) Physiological functions for brain NF-kappa B. Trends Neurosci 28:37–43

Negi G, Kumar A, Sharma SS (2011) Nrf2 and NF-kappaB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes. Curr Neurovasc Res 8:294–304

Palomer X, Capdevila-Busquets E, Alvarez-Guardia D, Barroso E, Pallàs M, Camins A, Davidson MM, Planavila A, Villarroya F, Vázquez-Carrera M (2013) Resveratrol induces nuclear factor-κB activity in human cardiac cells. Int J Cardiol 167:2507–2516

Palsamy P, Subramanian S (2008) Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomed Pharmacother 62:598–605

Palsamy P, Subramanian S (2010) Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic β-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats. J Cell Physiol 224:423–432

Patel S, Santani D (2009) Role of NF-kappa B in the pathogenesis of diabetes and its associated complications. Pharmacol Rep 61:595–603

Quinn S, O’Neill L (2011) A trio of microRNAs that control Toll-like receptor signaling. Int Immunol 23:421–425

Rains JL, Jain SK (2011) Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 50:567–575

Ramesh B, Pugalendi KV (2006) Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats. J Med Food 9:562–566

Ramkaran P, Khan S, Phulukdaree A, Moodley D, Chuturgoon AA (2014) miR-146a polymorphism influences levels of miR-146a, IRAK-1, and TRAF-6 in young patients with coronary artery disease. Cell Biochem Biophys 68:259–266

Roggli E, Britan A, Gattesco S, Lin-Marq N, Abderrahmani A, Meda P, Regazzi R (2010) Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells. Diabetes 59:978–986

Roghani M, Baluchnejadmojarad T (2010) Mechanisms underlying vascular effect of chronic resveratrol in streptozotocin-diabetic rats. Phytother Res 24:S148–S154

Rossetti L, DeFronzo RA, Gherzi R, Stein P, Andraghetti G, Falzetti G, Shulman GI, Klein-Robbenhaar E, Cordera R (1990) Effect of metformin treatment on insulin action in diabetic rats: in vivo and in vitro correlations. Metabolism 39:425–435

Sanz AB, Sanchez-Nino MD, Ramos AM, Moreno JA, Santamaria B, Ruiz-Ortega M (2010) NF-kappaB in renal inflammation. J Am Soc Nephrol 21:1254–1262

Shanmugam KR, Mallikarjuna K, Reddy KS (2011) Effect of alcohol on blood glucose and antioxidant enzymes in the liver and kidney of diabetic rats. Indian J Pharmacol 43:330–335

Singh CK, Kumar A, Hitchcock DB, Fan D, Goodwin R, LaVoie HA, Nagarkatti P, DiPette DJ, Singh US (2011) Resveratrol prevents embryonic oxidative stress and apoptosis associated with diabetic embryopathy and improves glucose and lipid profile of diabetic dam. Mol Nutr Food Res 55:1186–1196

Soufi FG, Mohammad-nejad D, Ahmadieh H (2012) Resveratrol improves diabetic retinopathy possibly through oxidative stress - nuclear factor kB - apoptosis pathway. Pharmacol Rep 64:1505–1514

Vaz C, Mer AS, Bhattacharya A, Ramaswamy R (2011) MicroRNAs modulate the dynamics of the NF-kB signaling pathway. PLoS One 6:e27774

Wang L, Chopp M, Szalad A, Zhang Y, Wang X, Zhang RL, Liu XS, Jia L, Zhang ZG (2014) The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy. Neuroscience 259:155–163

Wohaieb SA, Godin DV (1987) Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment. Diabetes 36:1014–1018

Zhao JL, Rao DS, O'Connell RM, Garcia-Flores Y, Baltimore D (2013) MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice. Elife 2:e00537