Journal of Pharmacokinetics and Pharmacodynamics
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A modeling approach for compounds affecting body composition
Journal of Pharmacokinetics and Pharmacodynamics - - 2013
Pharmacometric estimation methods for aggregate data, including data simulated from other pharmacometric models
Journal of Pharmacokinetics and Pharmacodynamics - Tập 48 Số 5 - Trang 623-638 - 2021
AbstractLack of data is an obvious limitation to what can be modelled. However,
aggregate data in the form of means and possibly (co)variances, as well as
previously published pharmacometric models, are often available. Being able to
use all available data is desirable, and therefore this paper will outline
several methods for using aggregate data as the basis of parameter estimation.
The presente...
Individualized optimization of colistin loading doses
Journal of Pharmacokinetics and Pharmacodynamics - Tập 50 - Trang 11-20 - 2022
Colistin remains one of the few available options for the treatment of
infections caused by resistant bacteria. Pharmacokinetic (PK) studies have been
successful in estimating the appropriate colistin methanesulfonate (CMS) dose to
achieve a target colistin concentration. Currently, there is a consensus that
the dose of CMS should vary according to the patient renal function since CMS is
mainly el...
A physiologically-motivated model of cystic fibrosis liquid and solute transport dynamics across primary human nasal epithelia
Journal of Pharmacokinetics and Pharmacodynamics - Tập 46 - Trang 457-472 - 2019
Cystic fibrosis (CF) disease is caused by mutations affecting the gene coding
for the cystic fibrosis transmembrane conductance regulator (CFTR), an anion
channel expressed in the mucosal side of epithelial tissue. In the airway,
dysfunctional CFTR results in a transepithelial osmotic imbalance leading to
hyperabsorption of airway surface liquid mucostasis, chronic inflammation, and
eventual respi...
Using early biomarker data to predict long-term bone mineral density: application of semi-mechanistic bone cycle model on denosumab data
Journal of Pharmacokinetics and Pharmacodynamics - Tập 42 - Trang 333-347 - 2015
Osteoporosis is a chronic skeletal disease characterized by low bone strength
resulting in increased fracture risk. New treatments for osteoporosis are still
an unmet medical need because current available treatments have various
limitations. Bone mineral density (BMD) is an important endpoint for evaluating
new osteoporosis treatments; however, the BMD response is often slower and less
profound t...
Assessment of glycemic response to an oral glucokinase activator in a proof of concept study: application of a semi-mechanistic, integrated glucose-insulin-glucagon model
Journal of Pharmacokinetics and Pharmacodynamics - Tập 40 - Trang 67-80 - 2012
A proof of concept study was conducted to investigate the safety and
tolerability of a novel oral glucokinase activator, LY2599506, during multiple
dose administration to healthy volunteers and subjects with Type 2 diabetes
mellitus (T2DM). To analyze the study data, a previously established
semi-mechanistic integrated glucose-insulin model [1–5] was extended to include
characterization of glucago...
A new mathematical pharmacodynamic model of clonogenic cancer cell death by doxorubicin
Journal of Pharmacokinetics and Pharmacodynamics - - 2013
Previous models for predicting tumor cell growth are mostly based on
measurements of total cell numbers. The purpose of this paper is to provide a
new simple mathematical model for calculating tumor cell growth focusing on the
fraction of cells that is clonogenic. The non-clonogenic cells are considered to
be relatively harmless. We performed a number of different types of experiments:
a long-term...
Modeling Nicotine Arterial–Venous Differences to Predict Arterial Concentrations and Input Based on Venous Measurements: Application to Smokeless Tobacco and Nicotine Gum
Journal of Pharmacokinetics and Pharmacodynamics - Tập 29 - Trang 383-402 - 2002
Significant arterio-venous differences in nicotine concentrations have been
observed during and after cigarette smoking, nicotine nasal spray, and
intravenous nicotine administration. In this paper we describe a novel
mathematical method for estimating arterial blood levels from venous blood level
data. The model allows to quantify: (i) the influence of the microcirculation in
the hands and forear...
The American Conference on Pharmacometrics 2016 (ACoP7)
Journal of Pharmacokinetics and Pharmacodynamics - Tập 43 - Trang 1-2 - 2016
Abstracts Accepted for American Conference on Pharmacometrics 2015 (ACoP6)
Journal of Pharmacokinetics and Pharmacodynamics - Tập 42 - Trang 11-107 - 2015
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