Journal of Pharmacokinetics and Pharmacodynamics

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A modeling approach for compounds affecting body composition
Journal of Pharmacokinetics and Pharmacodynamics - - 2013
Peter Gennemark, Rasmus Jansson‐Löfmark, Gina Hyberg, Maria Wigstrand, Dorota Kakol-Palm, Pernilla Håkansson, Daniel Hovdal, Peter Brodin, Maria Fritsch-Fredin, Madeleine Antonsson, Karolina Ploj, Johan Gabrielsson
Pharmacometric estimation methods for aggregate data, including data simulated from other pharmacometric models
Journal of Pharmacokinetics and Pharmacodynamics - Tập 48 Số 5 - Trang 623-638 - 2021
Pyry A. J. Välitalo
AbstractLack of data is an obvious limitation to what can be modelled. However, aggregate data in the form of means and possibly (co)variances, as well as previously published pharmacometric models, are often available. Being able to use all available data is desirable, and therefore this paper will outline several methods for using aggregate data as the basis of p...... hiện toàn bộ
Individualized optimization of colistin loading doses
Journal of Pharmacokinetics and Pharmacodynamics - Tập 50 - Trang 11-20 - 2022
Aline Vidal Lacerda Gontijo, André V. G. Cavalieri
Colistin remains one of the few available options for the treatment of infections caused by resistant bacteria. Pharmacokinetic (PK) studies have been successful in estimating the appropriate colistin methanesulfonate (CMS) dose to achieve a target colistin concentration. Currently, there is a consensus that the dose of CMS should vary according to the patient renal function since CMS is mainly el...... hiện toàn bộ
A physiologically-motivated model of cystic fibrosis liquid and solute transport dynamics across primary human nasal epithelia
Journal of Pharmacokinetics and Pharmacodynamics - Tập 46 - Trang 457-472 - 2019
Florencio Serrano Castillo, Carol A. Bertrand, Michael M. Myerburg, Monica E. Shapiro, Timothy E. Corcoran, Robert S. Parker
Cystic fibrosis (CF) disease is caused by mutations affecting the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel expressed in the mucosal side of epithelial tissue. In the airway, dysfunctional CFTR results in a transepithelial osmotic imbalance leading to hyperabsorption of airway surface liquid mucostasis, chronic inflammation, and eventual respi...... hiện toàn bộ
Using early biomarker data to predict long-term bone mineral density: application of semi-mechanistic bone cycle model on denosumab data
Journal of Pharmacokinetics and Pharmacodynamics - Tập 42 - Trang 333-347 - 2015
Jenny Zheng, Erno van Schaick, Liviawati Sutjandra Wu, Philippe Jacqmin, Juan Jose Perez Ruixo
Osteoporosis is a chronic skeletal disease characterized by low bone strength resulting in increased fracture risk. New treatments for osteoporosis are still an unmet medical need because current available treatments have various limitations. Bone mineral density (BMD) is an important endpoint for evaluating new osteoporosis treatments; however, the BMD response is often slower and less profound t...... hiện toàn bộ
Assessment of glycemic response to an oral glucokinase activator in a proof of concept study: application of a semi-mechanistic, integrated glucose-insulin-glucagon model
Journal of Pharmacokinetics and Pharmacodynamics - Tập 40 - Trang 67-80 - 2012
Karen B. Schneck, Xin Zhang, Robert Bauer, Mats O. Karlsson, Vikram P. Sinha
A proof of concept study was conducted to investigate the safety and tolerability of a novel oral glucokinase activator, LY2599506, during multiple dose administration to healthy volunteers and subjects with Type 2 diabetes mellitus (T2DM). To analyze the study data, a previously established semi-mechanistic integrated glucose-insulin model [1–5] was extended to include characterization of glucago...... hiện toàn bộ
A new mathematical pharmacodynamic model of clonogenic cancer cell death by doxorubicin
Journal of Pharmacokinetics and Pharmacodynamics - - 2013
Jan Lankelma, Rafael Fernández Luque, Henk Dekker, Jaap van den Berg, Bob Kooi
Previous models for predicting tumor cell growth are mostly based on measurements of total cell numbers. The purpose of this paper is to provide a new simple mathematical model for calculating tumor cell growth focusing on the fraction of cells that is clonogenic. The non-clonogenic cells are considered to be relatively harmless. We performed a number of different types of experiments: a long-term...... hiện toàn bộ
Modeling Nicotine Arterial–Venous Differences to Predict Arterial Concentrations and Input Based on Venous Measurements: Application to Smokeless Tobacco and Nicotine Gum
Journal of Pharmacokinetics and Pharmacodynamics - Tập 29 - Trang 383-402 - 2002
Maria Pitsiu, Jean-Michel Gries, Neal Benowitz, Steven G. Gourlay, Davide Verotta
Significant arterio-venous differences in nicotine concentrations have been observed during and after cigarette smoking, nicotine nasal spray, and intravenous nicotine administration. In this paper we describe a novel mathematical method for estimating arterial blood levels from venous blood level data. The model allows to quantify: (i) the influence of the microcirculation in the hands and forear...... hiện toàn bộ
The American Conference on Pharmacometrics 2016 (ACoP7)
Journal of Pharmacokinetics and Pharmacodynamics - Tập 43 - Trang 1-2 - 2016
Daniele Ouellet, Mirjam N. Trame, Brian Corrigan
Abstracts Accepted for American Conference on Pharmacometrics 2015 (ACoP6)
Journal of Pharmacokinetics and Pharmacodynamics - Tập 42 - Trang 11-107 - 2015
Tổng số: 745   
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