Journal of Pharmacokinetics and Biopharmaceutics
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Phân tích sự phân phối của pethidine ở chuột mang thai bằng cách sử dụng mô hình dòng sinh lý học Dịch bởi AI
Journal of Pharmacokinetics and Biopharmaceutics - Tập 14 - Trang 381-395 - 1986
Sự phân phối của pethidine (meperidine) trong chuột mang thai được mô tả bằng mô hình dòng sinh lý học. Mô hình này bao gồm máu động mạch và tĩnh mạch, não, mô mỡ, thai nhi, gan, ruột, cơ, phổi và thận. Các hồ sơ nồng độ-thời gian của pethidine được tính toán qua mô hình phù hợp với dữ liệu thực nghiệm, ngoại trừ mô não và thận, nơi mà mô hình dự đoán nồng độ ban đầu cao hơn. Các mô phỏng được thự......
Gastrointestinal absorption of quinidine from some solutions and commercial tablets
Journal of Pharmacokinetics and Biopharmaceutics - Tập 8 - Trang 243-255 - 1980
The gastrointestinal absorption of quinidine from three commercially available tablet products has been compared to that from a quinidine sulfate solution previously found to have 70% of the systematic availability of an intravenous dose. Quinidine gluconate solution was included in the study to compare the absorption characteristics of the two quinidine salts. The tablets were given in a counter......
Mathematical Modeling of Circadian Cortisol Concentrations Using Indirect Response Models: Comparison of Several Methods
Journal of Pharmacokinetics and Biopharmaceutics - Tập 27 - Trang 23-43 - 1999
Six mathematical functions to describe the chronobiology of cortisol concentrations were assessed. Mean data from a dose-proportionality study of inhaled fluticasone propionate were fitted with an indirect response model using various biorhythmic functions (single cosine, dual ramps, dual zero-order, dual cosines, and Fourier series with 2 and n-harmonics) for production rate. Data with known par......
Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysis
Journal of Pharmacokinetics and Biopharmaceutics - Tập 18 - Trang 459-481 - 1990
The concentration EEG effect relationship of heptabarbital was modeled using effect parameters derived from aperiodic EEG analysis. Male Wistar rats (n=10) received an intravenous infusion of heptabarbital at a rate of 6–9 mg/kg per min until burst suppression with isoelectric periods of 5 sec or longer. Arterial blood samples were obtained and EEG was measured continuously until recovery of basel......
Pharmacokinetics of rec-hirudin in healthy volunteers after intravenous administration
Journal of Pharmacokinetics and Biopharmaceutics - Tập 22 - Trang 147-156 - 1994
The pharmacokinetics of recombinant hirudin (rec-hirudin, Ciba-Geigy, CGP 39 393) in healthy volunteers after iv administration was investigated on the basis of the data from five different studies. A total of 77 plasma profiles following a single iv bolus dose of either 0.1, 0.3, 0.5, or 1 mg/kg of rec-hirudin was used for the evaulation. Plasma concentrations and especially AUC were proportional......
Linear and nonlinear kinetics of drug elimination I. Kinetics on the basis of a single capacity-limited pathway of elimination with or without simultaneous supply-limited elimination
Journal of Pharmacokinetics and Biopharmaceutics - Tập 2 - Trang 395-415 - 2015
The pharmacokinetic behavior of foreign substances that are completely or partially eliminated via metabolism by saturable enzyme systems is analyzed. General integrated equations are derived which describe the time course of the plasma concentration under the assumption of a saturable enzyme system according to Michaelis-Menten kinetics in combination with normal firstorder elimi......
Pharmacokinetic parameter estimations by minimum relative entropy method
Journal of Pharmacokinetics and Biopharmaceutics - Tập 23 - Trang 479-494 - 1995
For estimating pharmacokinetic parameters, we introduce the minimum relative entropy (MRE) method and compare its performance with least squares methods. There are several variants of least squares, such as ordinary least squares (OLS), weighted least squares, and iteratively reweighted least squares. In addition to these traditional methods, even extended least squares (ELS), a relatively new app......
Predicting the Time Needed to Achieve Steady State If Absorption and Elimination Constants Are Equal
Journal of Pharmacokinetics and Biopharmaceutics - Tập 27 - Trang 297-300 - 1999
A simple table is derived to facilitate the rapid estimation of the number of dose administrations needed to achieve a certain fraction of the steady-state plasma concentration in the case of one-compartment model with uniform multiple oral dosing and equal absorption and elimination constants.
Effects of the rate and composition of fluid replacement on the pharmacokinetics and pharmacodynamics of intravenous furosemide
Journal of Pharmacokinetics and Biopharmaceutics - Tập 14 - Trang 495-509 - 1986
Effects of differences in the rate and composition of intravenous fluid replacement for urine loss on the pharmacokinetics and pharmacodynamics of furosemide were evaluated using the dog as a model animal. Each of six dogs received 8-hr constant intravenous infusion of 20 mg (15 mg used in one dog) of furosemide with 0% replacement (treatment I), 50% replacement (treatment II), and 100% replaceme......
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