Journal of Pharmacokinetics and Biopharmaceutics
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Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysis
Journal of Pharmacokinetics and Biopharmaceutics - Tập 18 - Trang 459-481 - 1990
The concentration EEG effect relationship of heptabarbital was modeled using effect parameters derived from aperiodic EEG analysis. Male Wistar rats (n=10) received an intravenous infusion of heptabarbital at a rate of 6–9 mg/kg per min until burst suppression with isoelectric periods of 5 sec or longer. Arterial blood samples were obtained and EEG was measured continuously until recovery of basel......
Pharmacokinetic/pharmacodynamic modeling: What it is!
Journal of Pharmacokinetics and Biopharmaceutics - Tập 15 - Trang 545-553 - 1987
Although Pharmacokinetic/pharmacodynamic modeling has been around for decades, it is still in its infancy with respect to the future of its current manifestation. Due to the amount of time and other resources that must be committed for successful development and application of these methods, economic incentives must be made available to academic and industrial scientists through t......
Concurrent intravenous administration of a labeled tracer to determine the oral bioavailability of a drug exhibiting Michaelis-Menten metabolism
Journal of Pharmacokinetics and Biopharmaceutics - Tập 15 - Trang 615-631 - 1987
The theoretical accuracy of concurrent administration of labeled intravenous tracer and oral doses to estimate the bioavailability of drugs exhibiting Michaelis-Menten kinetics was determined by computer simulation. The simulation model consisted of sampling and hepatic compartments with elimination occurring by hepatic metabolism according to the venous equilibration model. The relationships bet......
The pharmacokinetics and pharmacodynamics of bumetanide in normal subjects
Journal of Pharmacokinetics and Biopharmaceutics - Tập 10 - Trang 393-409 - 1982
The pharmacokinetics and pharmacodynamics of bumetanide (1 mg) administered either orally or intravenously were studied in a group of normal subjects using high-pressure liquid chromatography. A two-compartment model adequately fitted the intravenous data. Renal clearance (85 ml min−1 contributed 65% to the total elimination of bumetanide irrespective of whether a model-dependent or model-independ......
Mean residence time in peripheral tissue
Journal of Pharmacokinetics and Biopharmaceutics - Tập 15 - Trang 439-450 - 1987
The published methods for determining the mean residence time for drugs in peripheral tissue are reviewed in terms of assumptions involved, advantages and disadvantages. A method for determining mean transit time in peripheral tissue is proposed; this may be a more useful indicator of the tissue retention properties for drug compounds.
Correlation betweenin vitro andin vivo drug metabolism rate: Oxidation of ethoxybenzamide in rat
Journal of Pharmacokinetics and Biopharmaceutics - - 1978
Application of the axial dispersion model of hepatic drug elimination to the kinetics of diazepam in the isolated perfused rat liver
Journal of Pharmacokinetics and Biopharmaceutics - Tập 20 - Trang 171-193 - 1992
The application of the axial dispersion model to diazepam hepatic elimination was evaluated using data obtained for several conditions using the single-pass isolated perfused rat liver preparation. The influence of alterations in the fraction unbound in perfusate (fu) and perfusate flow (Q) on the availability (F) of diazepam was studied under steady conditions (n=4 in each case). Changes in fu we......
On the recording of sample times and parameter estimation from repeated measures pharmacokinetic data
Journal of Pharmacokinetics and Biopharmaceutics - Tập 24 Số 6 - Trang 637-650 - 1996
A multi-center study to evaluate the pharmacokinetic and clinical interactions between alprazolam and imipramine
Journal of Pharmacokinetics and Biopharmaceutics - Tập 19 - Trang S93-S100 - 1991
The results of this study document the safety of co-administering alprazolam at doses up to 4 mg per day to patients already receiving imipramine. Although a pharmacokinetic interaction was observed by both a traditional analysis approach and a population analysis approach resulting in a significant increase in imipramine and desipramine plasma concentrations, no adverse pharmacodynamic effects we......
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