Journal of Pharmacokinetics and Biopharmaceutics
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
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Phân tích sự phân phối của pethidine ở chuột mang thai bằng cách sử dụng mô hình dòng sinh lý học Dịch bởi AI
Journal of Pharmacokinetics and Biopharmaceutics - Tập 14 - Trang 381-395 - 1986
Sự phân phối của pethidine (meperidine) trong chuột mang thai được mô tả bằng mô
hình dòng sinh lý học. Mô hình này bao gồm máu động mạch và tĩnh mạch, não, mô
mỡ, thai nhi, gan, ruột, cơ, phổi và thận. Các hồ sơ nồng độ-thời gian của
pethidine được tính toán qua mô hình phù hợp với dữ liệu thực nghiệm, ngoại trừ
mô não và thận, nơi mà mô hình dự đoán nồng độ ban đầu cao hơn. Các mô phỏng
được thự...
Gastrointestinal absorption of quinidine from some solutions and commercial tablets
Journal of Pharmacokinetics and Biopharmaceutics - Tập 8 - Trang 243-255 - 1980
The gastrointestinal absorption of quinidine from three commercially available
tablet products has been compared to that from a quinidine sulfate solution
previously found to have 70% of the systematic availability of an intravenous
dose. Quinidine gluconate solution was included in the study to compare the
absorption characteristics of the two quinidine salts. The tablets were given in
a counterb...
Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysis
Journal of Pharmacokinetics and Biopharmaceutics - Tập 18 - Trang 459-481 - 1990
The concentration EEG effect relationship of heptabarbital was modeled using
effect parameters derived from aperiodic EEG analysis. Male Wistar rats (n=10)
received an intravenous infusion of heptabarbital at a rate of 6–9 mg/kg per min
until burst suppression with isoelectric periods of 5 sec or longer. Arterial
blood samples were obtained and EEG was measured continuously until recovery of
basel...
Pharmacokinetics of rec-hirudin in healthy volunteers after intravenous administration
Journal of Pharmacokinetics and Biopharmaceutics - Tập 22 - Trang 147-156 - 1994
The pharmacokinetics of recombinant hirudin (rec-hirudin, Ciba-Geigy, CGP 39
393) in healthy volunteers after iv administration was investigated on the basis
of the data from five different studies. A total of 77 plasma profiles following
a single iv bolus dose of either 0.1, 0.3, 0.5, or 1 mg/kg of rec-hirudin was
used for the evaulation. Plasma concentrations and especially AUC were
proportional...
Linear and nonlinear kinetics of drug elimination I. Kinetics on the basis of a single capacity-limited pathway of elimination with or without simultaneous supply-limited elimination
Journal of Pharmacokinetics and Biopharmaceutics - Tập 2 - Trang 395-415 - 2015
The pharmacokinetic behavior of foreign substances that are completely or
partially eliminated via metabolism by saturable enzyme systems is analyzed.
General integrated equations are derived which describe the time course of the
plasma concentration under the assumption of a saturable enzyme system according
to Michaelis-Menten kinetics in combination with normal firstorder elimination
processes....
Analysis of Antiplatelet Effect of Ticlopidine In Humans: Modeling Based on Irreversible Inhibition of Platelet Precursors in Bone Marrow
Journal of Pharmacokinetics and Biopharmaceutics - Tập 27 - Trang 283-296 - 1999
The relationship between plasma concentration of ticlopidine and its inhibitory
effect on platelet aggregation in human was analyzed using a
pharmacokinetic/pharmacodynamic (PK/PD) model. The data of plasma concentration
and inhibitory effect on platelet aggregation were taken from the literature. A
two-compartment open model was fitted to plasma ticlopidine concentrations.
Assuming that ticlopidi...
Pharmacokinetic parameter estimations by minimum relative entropy method
Journal of Pharmacokinetics and Biopharmaceutics - Tập 23 - Trang 479-494 - 1995
For estimating pharmacokinetic parameters, we introduce the minimum relative
entropy (MRE) method and compare its performance with least squares methods.
There are several variants of least squares, such as ordinary least squares
(OLS), weighted least squares, and iteratively reweighted least squares. In
addition to these traditional methods, even extended least squares (ELS), a
relatively new app...
Effects of the rate and composition of fluid replacement on the pharmacokinetics and pharmacodynamics of intravenous furosemide
Journal of Pharmacokinetics and Biopharmaceutics - Tập 14 - Trang 495-509 - 1986
Effects of differences in the rate and composition of intravenous fluid
replacement for urine loss on the pharmacokinetics and pharmacodynamics of
furosemide were evaluated using the dog as a model animal. Each of six dogs
received 8-hr constant intravenous infusion of 20 mg (15 mg used in one dog) of
furosemide with 0% replacement (treatment I), 50% replacement (treatment II),
and 100% replacemen...
Models for describing absorption rate and estimating extent of bioavailability: Application to cefetamet pivoxil
Journal of Pharmacokinetics and Biopharmaceutics - Tập 20 - Trang 421-442 - 1992
Five absorption rate models have been compared for describing cefetamet data in
34 adults after oral administration of cefetamet pivoxil with food alone or in
combination with either an antacid or an H2 antagonist. A sequential zero- then
first-order input process provided the most flexible description of the
absorption rate of cefetamet. If the first-order rate constant is linked to the
zero- ord...
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