Journal of Pharmacokinetics and Biopharmaceutics
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Variability in derived parameters of furosemide pharmacokinetics
Journal of Pharmacokinetics and Biopharmaceutics - Tập 9 - Trang 623-633 - 1981
The pharmacokinetics of furosemide in normal man reported from a number of investigators show great discrepancies. We have evaluated the effect on derived pharmacokinetic parameters of furosemide of using different weighting factors or fewer data points to fit the same set of data to an exponential equation, or using noncompartmental analysis. Terminal half-lives of furosemide differed vastly, as...... hiện toàn bộ
Competing pathways in drug metabolism. II. An identical, anterior enzymic distribution for 2- and 5-sulfoconjugation and a posterior localization for 5-glucuronidation of gentisamide in the rat liver
Journal of Pharmacokinetics and Biopharmaceutics - Tập 16 - Trang 633-656 - 1988
Gentisamide (2,5-dihydroxybenzamide, GAM), a substrate that forms two monosulfates at the 2 and 5 positions (GAM-2S and GAM-5S) and a monoglucuronide at the 5 position (GAM-5G), was delivered at 8 or 80 μM by normal (N) and retrograde (R) flows to the once-through rat liver preparation. At the lower (8 μM) input concentration, ratios of conjugate formation rate, GAM-5S/GAM-5G and GAM-2S/GAM-5G, we...... hiện toàn bộ
Mean time parameters for generalized physiological flow models (semihomogeneous linear systems)
Journal of Pharmacokinetics and Biopharmaceutics - Tập 19 - Trang 319-331 - 1991
This note gives expressions for recirculation mean time parameters of the disposition kinetics of particles in a semihomogeneous stationary linear system. In such a system each compartment may have an arbitrary single-pass disposition function, rather than a known parametric (usually monoexponential) one. Such systems provide a generalization of physiological flow models. Given observations of art...... hiện toàn bộ
Modeling of Trough Plasma Bismuth Concentrations
Journal of Pharmacokinetics and Biopharmaceutics - Tập 25 - Trang 79-106 - 1997
Disposition pharmacokinetics of bismuth following oral dosing of ranitidine bismuth citrate are complicated and variable. An analysis of data from healthy volunteers suggests a model with three disposition compartments and first-order absorption. Patient data are pooled from 10 separate studies and consist of 1140 trough concentrations measured in 802 patients following dosing of 2 to 12 weeks du...... hiện toàn bộ
Nonlinear regression on multiple-dose data
Journal of Pharmacokinetics and Biopharmaceutics - Tập 7 - Trang 675-679 - 2015
Two examples are given to show how Metzler's nonlinear regression program can be used to estimate parameters in a model with multiple dosing. The model of one example is a set of equations involving sums of exponentials, whereas the other model is a set of differential equations reflecting first order absorption and Michaelis-Menten excretion. In both cases no data were given in one of the dosing...... hiện toàn bộ
The population pharmacokinetics of theophylline during the early postnatal period
Journal of Pharmacokinetics and Biopharmaceutics - Tập 19 - Trang S59-S77 - 1991
The following conclusions may be drawn from this study's results:
...... hiện toàn bộ
Rate of phenytoin accumulation in man: A simulation study
Journal of Pharmacokinetics and Biopharmaceutics - - 2015
Computer simulations were performed using a one-compartment open model with either first-order or zero-order input and either Michaelis-Menten or Michaelis-Menten and first-order elimination. Twelve theoretical cases constructed from various combinations of typical and atypical values for phenytoin pharmacokinetic parameters, V
max
and K
m
...... hiện toàn bộ
Comparison of Different Methods to Evaluate Population Dose–Response and Relative Potency: Importance of Interoccasion Variability
Journal of Pharmacokinetics and Biopharmaceutics - Tập 27 - Trang 67-83 - 1999
Different mixed-effects models were compared to evaluate the population dose–response and relative potency of two albuterol inhalers. Bronchodilator response was measured after ascending doses of each inhaler in 37 asthmatic patients. A linear mixed-effects model was developed based on the approach proposed by Finney for the evaluation of bioassay data. A nonlinear mixed-effects (Emax
) model wit...... hiện toàn bộ
Effects of pH on the accumulation of sulfonamides by fish
Journal of Pharmacokinetics and Biopharmaceutics - - 1981
The pH of water affects the accumulation of weak electrolytes by fish in the water. However, the relationships among water pH, weak electrolyte pKa and the rate and extent of accumulation of the weak electrolyte are poorly characterized. To better define these relationships, goldfish were immersed for varying periods of time in solutions of sulfonamides that were buffered at pHvalues from 5.4 to ...... hiện toàn bộ
Tổng số: 754
- 1
- 2
- 3
- 4
- 5
- 6
- 10