Predicting the Time Needed to Achieve Steady State If Absorption and Elimination Constants Are Equal

Journal of Pharmacokinetics and Biopharmaceutics - Tập 27 - Trang 297-300 - 1999
Júlia Singer1, László Vereczkey2
1Clinical Research and Development, Chinoin Pharmaceutical and Chemical Works Ltd., Budapest, Hungary
2Chemical Research Center, Institute of Chemistry, Hungarian Academy of Sciences, Budapest, Hungary

Tóm tắt

A simple table is derived to facilitate the rapid estimation of the number of dose administrations needed to achieve a certain fraction of the steady-state plasma concentration in the case of one-compartment model with uniform multiple oral dosing and equal absorption and elimination constants.