Journal of Pharmaceutical Health Care and Sciences

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A study on the chemical stability of cholesterol-lowering drugs in concomitant simple suspensions with magnesium oxide
Journal of Pharmaceutical Health Care and Sciences - Tập 9 Số 1
Ginjiro Kato, Hidemichi Mitome, Yoshimasa Miyauchi, Shigetaka Takeda, Yoshito Toyota, Noriaki Hidaka, Mamoru Tanaka, Kazuki Akira
Abstract Background Difficulty in taking solid medicines is a common issue particularly for the elderly because of a decline in swallowing function, also known as dysphagia. For patients with such a dysfunction, a simple suspension method, in which solid medicines are disintegrated and suspended usi...... hiện toàn bộ
Effect of rapid cefpodoxime disk screening for early detection of third-generation cephalosporin resistance in Escherichia coli and Klebsiella pneumoniae bacteremia
Journal of Pharmaceutical Health Care and Sciences - Tập 9 - Trang 1-9 - 2023
Mikiyasu Sakai, Takamasa Sakai, Yuki Nagata, Hiroko Komai, Yoshio Miyake, Toshitaka Watariguchi, Atsushi Kawabata, Fumiko Ohtsu
Several methods have been reported for detecting resistance genes or phenotypic testing on the day of positive blood culture in Escherichia coli or Klebsiella pneumoniae bacteremia. However, some facilities have not introduced these methods because of costs or other reasons. Toyota Kosei Hospital introduced cefpodoxime (CPDX) rapid screening on May 7, 2018, to enable early detection of third-gener...... hiện toàn bộ
Safety profile of prophylactic rescue dosing of immediate-release oral opioids in cancer patients
Journal of Pharmaceutical Health Care and Sciences - Tập 4 - Trang 1-7 - 2018
Rei Tanaka, Hiroshi Ishikawa, Tetsu Sato, Michihiro Shino, Katsuhiro Omae, Tetsumi Sato, Iwao Osaka
Appropriate prophylactic rescue dosing of opioids is considered effective for cancer pain relief, but no study has reported the safety of such prophylactic rescue. We compared the safety of prophylactic rescue dosing of immediate-release oral opioids with that of regular rescue dosing. The study included 103 cancer patients who used either immediate-release morphine syrup or immediate-release oxyc...... hiện toàn bộ
Efficacy of combined use of Suvorexant and Ramelteon in preventing postoperative delirium: a retrospective comparative study
Journal of Pharmaceutical Health Care and Sciences - Tập 9 - Trang 1-8 - 2023
Shoya Ikeuchi, Rei Tanaka, Teiichi Sugiura, Kaori Shinsato, Akane Wakabayashi, Junya Sato, Keiko Suzuki, Michihiro Shino
Suvorexant and ramelteon have been presented as useful for preventing postoperative delirium. Previous studies reported on the comparison with benzodiazepine hypnotics which have been known for the risk for inducing delirium, but the comparison with patients not taking any hypnotics has not been reported yet. Therefore, we assessed the incidence rates for postoperative delirium comparing cancer pa...... hiện toàn bộ
Application of ozone gas for decontamination of nucleoside anticancer drugs
Journal of Pharmaceutical Health Care and Sciences - Tập 2 - Trang 1-4 - 2016
Ayumi Tsukamoto, Shunji Ishiwata, Asami Kajimoto, Ryusuke Murata, Rika Kitano, Tomomi Inoue, Takeshi Kotake
Exposure to anticancer drugs is hazardous and may lead to chromosomal abnormalities and spontaneous abortion in healthcare workers. Guidelines recommend surface decontamination and cleaning in order to minimize the occupational exposure to anticancer drugs, although no single process has been found to deactivate all currently available hazardous drugs. Ozone gas is oxidative and a decontaminant fo...... hiện toàn bộ
Incidence and risk factors of neonatal hypoglycemia after ritodrine therapy in premature labor: a retrospective cohort study
Journal of Pharmaceutical Health Care and Sciences - Tập 5 - Trang 1-7 - 2019
Shoko Shimokawa, Akiko Sakata, Yukio Suga, Kazuya Isoda, Shingo Itai, Katsuhiko Nagase, Tsutomu Shimada, Yoshimichi Sai
Ritodrine hydrochloride (RD), a β2-adrenergic agonist, is widely used as a tocolytic medication to suppress premature labor, but can cause neonatal hypoglycemia, a potentially severe side effect. We examined the incidence and risk factors of neonatal hypoglycemia following maternal intravenous administration of RD. This was a retrospective study of neonates, who had birth weight of ≥2000 g and wer...... hiện toàn bộ
Onset of analgesia with ibuprofen sodium in tension-type headache: a randomized trial
Journal of Pharmaceutical Health Care and Sciences - Tập 1 - Trang 1-9 - 2015
Elias Packman, Rina Leyva, David Kellstein
Ibuprofen is known to be efficacious in the treatment of tension-type headache, the most common form of primary headache. A novel tablet formulation of ibuprofen sodium is more rapidly absorbed than standard ibuprofen. This study evaluated onset of analgesia and overall efficacy of ibuprofen sodium in episodic-type tension headache (ETTH) compared with standard ibuprofen and placebo. This randomiz...... hiện toàn bộ
Retrospective investigation of combination therapy with clarithromycin and levofloxacin for pulmonary Mycobacterium avium complex disease
Journal of Pharmaceutical Health Care and Sciences - Tập 1 - Trang 1-6 - 2015
Hitoshi Shimomura, Airi Ono, Keiko Imanaka, Toru Majima, Hidenori Masuyama, Tsugumichi Sato, Takao Aoyama
Fluoroquinolones are often used for the treatment of refractory Mycobacterium avium complex (MAC) disease when the clinical efficacy of the recommended regimen, which includes clarithromycin (CAM), rifampicin (RFP), and ethambutol (EB), is insufficient. However, recent in vitro and in vivo studies have suggested that fluoroquinolones decreased the antibacterial activity of CAM when they were admin...... hiện toàn bộ
Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk
Journal of Pharmaceutical Health Care and Sciences - Tập 9 - Trang 1-10 - 2023
Ayako Furugen, Ayako Nishimura, Takeshi Umazume, Hina Ishikawa, Katsuya Narumi, Masaki Kobayashi
Epilepsy is a common neurological disorder. Lacosamide is a third-generation antiepileptic drug used to treat partial-onset seizures. Limited information is currently available on the transfer of lacosamide to breast milk. To facilitate studies on the safety of lacosamide use during breastfeeding, we aimed to develop a method to quantify lacosamide in human breast milk and plasma using ultra-perfo...... hiện toàn bộ
Drug-related problems and its determinant among hospitalized neonates with sepsis at Jimma University Medical Center, Ethiopia: a prospective observational study
Journal of Pharmaceutical Health Care and Sciences - Tập 7 Số 1 - 2021
Mengist Awoke Yizengaw, Tsegaye Melaku, Mohammed Beshir
Abstract Background Neonatal populations are quite susceptible to drug-related problems (DRPs) because of clinical heterogeneity and clinical practice trends. However, studies reporting DRPs in the neonatal population are quite limited. ... hiện toàn bộ
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