Tumor necrosis factor-α-mediated severity of idiopathic retinal periphlebitis in young adults (Eales’ disease): implication for anti-TNF-α therapyJournal of Ocular Biology, Diseases, and Informatics - Tập 3 - Trang 35-38 - 2010
Sandeep Saxena, Aditya B. Pant, Vinay K. Khanna, Kamlesh Singh, Rajendra K. Shukla, Carsten H. Meyer, Vijay K. Singh
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic inflammatory cytokine. Tumor necrosis factor-alpha was evaluated in the serum samples of patients with idiopathic retinal periphlebitis in young adults (Eales’ disease). Retinal periphlebitis was graded according to a new grading system based on severity of inflammation (grade 1–4). Quantification of the TNF-α levels was carried out using ELISA ...... hiện toàn bộ
Association of contrast sensitivity with LogMAR visual acuity and glycosylated hemoglobin in non-insulin dependent diabetes mellitusJournal of Ocular Biology, Diseases, and Informatics - Tập 3 - Trang 60-63 - 2010
Shaili Misra, Sandeep Saxena, Poonam Kishore, Shashi K. Bhasker, Arvind Misra, Carsten H. Meyer
A tertiary care center-based prospective case–control study was undertaken to evaluate the association of contrast sensitivity with LogMAR visual acuity and glycosylated hemoglobin (HbA1c) in 205 cases of non-insulin dependent diabetes mellitus and 115 controls. LogMAR visual acuity and contrast sensitivity were scored using ETDRS and Pelli-Robson charts, respectively. Bivariate correlation betwee...... hiện toàn bộ
Comparative modeling of PON2 and analysis of its substrate binding interactions using computational methodsJournal of Ocular Biology, Diseases, and Informatics - Tập 3 - Trang 64-72 - 2011
Subramanian Barathi, Muralidaran Charanya, Shivashanmugam Muthukumaran, Narayanasamy Angayarkanni, Vetrivel Umashankar
Paraoxonase (PON) constitutes a family of calcium-dependent mammalian enzymes comprising of PON1, PON2, and PON3. PON family shares ~60% sequence homology. These enzymes exhibit multiple activities like paraoxonase, arylesterase, and lactonase in a substrate dependent manner. Decreased PON activity has been reported in diseases like cardiovascular disease, atherosclerosis, and diabetes. Even thoug...... hiện toàn bộ
RPE barrier breakdown in diabetic retinopathy: seeing is believingJournal of Ocular Biology, Diseases, and Informatics - Tập 4 - Trang 83-92 - 2011
Hui-Zhuo Xu, Zhiming Song, Shuhua Fu, Meili Zhu, Yun-Zheng Le
Diabetic retinopathy (DR) is a major complication of diabetes and a leading cause of blindness in working-age Americans. DR is traditionally regarded as a disorder of blood–retina barriers, and the leakage of blood content is a major pathological characteristic of the disease. While the breakdown of the endothelial barrier in DR has been investigated extensively, the vascular leakage through the r...... hiện toàn bộ