Tumor necrosis factor-α-mediated severity of idiopathic retinal periphlebitis in young adults (Eales’ disease): implication for anti-TNF-α therapy

Sandeep Saxena1, Aditya B. Pant2, Vinay K. Khanna2, Kamlesh Singh3, Rajendra K. Shukla2, Carsten H. Meyer4, Vijay K. Singh5
1Department of Ophthalmology, CSM Medical University, Lucknow, India
2Indian Institute of Toxicological Research, Lucknow, India
3KGMC Institute of Clinical Epidemiology, CSM Medical University, Lucknow, India
4Department of Ophthalmology, University of Bonn, Bonn, Germany
5Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Bethesda, USA

Tóm tắt

Tumor necrosis factor-alpha (TNF-α) is a pleiotropic inflammatory cytokine. Tumor necrosis factor-alpha was evaluated in the serum samples of patients with idiopathic retinal periphlebitis in young adults (Eales’ disease). Retinal periphlebitis was graded according to a new grading system based on severity of inflammation (grade 1–4). Quantification of the TNF-α levels was carried out using ELISA kit in the serum samples of young adults with idiopathic retinal periphlebitis (n = 17) and healthy controls (n = 17) of similar age. Tumor necrosis factor-α level was found to be significantly raised in cases with retinal periphlebitis as compared with controls (p < 0.001). Higher levels of TNF-α were found to be associated with increased severity of retinal periphlebitis. Tumor necrosis factor-α represents a novel target for controlling inflammatory activity in idiopathic retinal periphlebitis. Higher levels of TNF-α, in association with the increased severity of retinal periphlebitis, have implications for early anti-TNF-α therapy.

Tài liệu tham khảo

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