Journal of Obstetrics and Gynaecology Research
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Association between nephrinuria, podocyturia, and proteinuria in women with pre‐eclampsia
Journal of Obstetrics and Gynaecology Research - Tập 43 Số 1 - Trang 34-41 - 2017
AbstractAimPodocyte depletion in the kidney is associated with end‐stage kidney
disease (ESKD). Pre‐eclampsia (PE) increases the risk of ESKD in later life.
This study was performed to determine whether nephrinuria (soluble nephrin in
the urine) is correlated with proteinuria and/or podocyturia (podocytes in the
urine) in PE women.MethodsEighty‐three urine samples, consisting of 45 and 38
samples ...
Post‐partum podocyturia following pre‐eclamptic pregnancy
Journal of Obstetrics and Gynaecology Research - Tập 43 Số 6 - Trang 1008-1013 - 2017
AbstractAimUrine podocin mRNA expression and urine podocin : nephrin mRNA
expression ratio (PNR) increase with increasing proteinuria during pregnancy
complicated with pre‐eclampsia (PE). This suggests that urine podocytes with
reduced nephrin mRNA expression are abundant in pathological podocyturia. The
aim of this study was therefore to determine post‐partum changes in podocyturia
and PNR in rel...
Genetic markers for inherited thrombophilia are associated with fetal growth retardation in the population of Central Russia
Journal of Obstetrics and Gynaecology Research - Tập 43 Số 7 - Trang 1139-1144 - 2017
AbstractAimThe aim of this study was to examine the role of hereditary
thrombophilia in the development of fetal growth retardation (FGR) in the
population of Central Russia.MethodsThe case–control study sample included 497
women in the third trimester of pregnancy recruited during 2009–2013. The
participants were enrolled into two groups: patients with FGR (n = 250) and
controls without FGR (n = ...
The efficacy of medical treatment for adenomyosis after adenomyomectomy
Journal of Obstetrics and Gynaecology Research - Tập 46 Số 10 - Trang 2092-2099 - 2020
AbstractAimsTo compare the efficacy of gonadotropin‐releasing hormone agonist
(GnRH‐a) and GnRH‐a + levonorgestrel‐releasing intrauterine system (LNG‐IUS)
after adenomyomectomy for improved adenomyosis‐associated
symptoms.MethodsOverall, 193 patients with adenomyosis included in this study
were categorized into three groups: adenomyomectomy (n = 57, group 1),
adenomyomectomy + GnRH‐a (n = 83, grou...
Valproic acid alleviates generalized hyperalgesia in mice with induced adenomyosis
Journal of Obstetrics and Gynaecology Research - Tập 37 Số 7 - Trang 696-708 - 2011
AbstractEmerging evidence suggests that adenomyosis, like endometriosis, may
also be an epigenetic disease. In this study, we evaluated the effect of
valproic acid (VPA) in ICR mice with adenomyosis, induced by neonatal dosing
with tamoxifen. For all mice, we evaluated the bodyweight and the response to
thermal stimuli by hotplate and tail‐flick tests 4, 8, and 12 weeks after
dosing, respectively,...
Adverse symptoms during short‐term use of ulipristal acetate in women with uterine myomas and/or adenomyosis
Journal of Obstetrics and Gynaecology Research - Tập 45 Số 4 - Trang 865-870 - 2019
AbstractAimTo evaluate various adverse symptoms during short‐term use of
ulipristal acetate in women with uterine myomas (n = 90), adenomyosis (n = 3) or
both (n = 7).MethodsOne hundred premenopausal women who received ulipristal
acetate for 4–12 weeks during 2016 to 2017 were selected. The medical records
were reviewed and the following information was collected; adverse symptoms
during medicatio...
Long‐term use of dienogest in the treatment of painful symptoms in adenomyosis
Journal of Obstetrics and Gynaecology Research - Tập 43 Số 9 - Trang 1441-1448 - 2017
AbstractAimWe aimed to investigate the safety and efficacy of dienogest (DNG), a
progestational 19‐norsteroid, administered for 52 weeks in patients with
symptomatic adenomyosis.MethodsA total of 130 patients with adenomyosis received
2 mg of DNG orally each day for 52 weeks. In cases of complicated anemia,
patients were treated for anemia prior to receiving the medication. Adverse
events and adve...
Long‐term dienogest administration in patients with symptomatic adenomyosis
Journal of Obstetrics and Gynaecology Research - Tập 44 Số 8 - Trang 1439-1444 - 2018
AbstractAimAdenomyosis is a common gynecological disorder that causes
dysmenorrhea, hypermenorrhea and metrorrhagia. Previously, we reported that
24 weeks of dienogest treatment is highly effective for pain in symptomatic
adenomyosis. Up to present, there is no report that describes treatment of
adenomyosis with long‐term dienogest administration for more than 2 years. In
this retrospective cohort...
Long‐term use of dienogest for the treatment of primary and secondary dysmenorrhea
Journal of Obstetrics and Gynaecology Research - Tập 46 Số 4 - Trang 606-617 - 2020
AbstractAimTo investigate the safety and efficacy of dienogest (DNG), a
progestational 19‐norsteroid, administered for 52 weeks in patients with primary
and secondary dysmenorrhea.MethodsA total of 147 patients with dysmenorrhea
received 1 mg of DNG orally each day for 52 weeks. The dose could be increased
to 2 mg/day at or after Week 12 according to the investigator's determination.
The primary s...
Combination of microwave endometrial ablation and postoperative dienogest administration is effective for treating symptomatic adenomyosis
Journal of Obstetrics and Gynaecology Research - Tập 44 Số 9 - Trang 1787-1792 - 2018
AbstractAimMenorrhagia and dysmenorrhea are common symptoms. Uterine adenomyosis
is one of the causes of menorrhagia and dysmenorrhea. These symptoms often
decrease the quality of life in women. Microwave endometrial ablation (MEA) is a
recently developed procedure that enables endometrial ablation. Dienogest has
long been used to suppress endometrium development and reduce
adenomyosis‐related dys...
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