Defining polycystic ovary syndrome phenotype in Vietnamese women

Journal of Obstetrics and Gynaecology Research - Tập 45 Số 11 - Trang 2209-2219 - 2019
Ngọc Thành Cao1, Minh Tâm Lê1, Vũ Quốc Huy Nguyễn1, Justin Pilgrim2, Viết Nguyên Sa Lê3, Dinh Duong Le4, Chi Kong Pham5, Devora Aharon6, Micah J. Hill2
1Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
2Department of Obstetrics and Gynecology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA
3Department of Obstetrics and Gynecology, Hue Central Hospital, Hue, Vietnam
4Department of Public Health, Hue University of Medicine and Pharmacy, Hue, Vietnam.
5Department of Obstetrics and Gynecology, Danang Women and Children hospital, Danang, Vietnam
6Department of OBGYN, Icahn School of Medicine, Mount Sinai, New York, USA

Tóm tắt

AbstractAimThis study aimed to evaluate the unique phenotype of the Vietnamese polycystic ovarian syndrome (PCOS) population.MethodsIn this multicenter cross‐sectional descriptive study, a total of 901 reproductive‐age women were recruited at three medical centers in Vietnam from June 2016 to May 2018. Group I included 479 patients with PCOS (Rotterdam 2003 consensus) and Group II included 422 non‐PCOS women, consisted of women with regular menstrual cycle, collected at the same time of PCOS recruitment, without ovarian disease or ovarian failure. Main outcome measures were anthropomorphic, serum hormone, ultrasound and physical characteristics of PCOS.ResultsThe Vietnamese PCOS population was lean, but with a higher weight and body mass index compared to controls. About 34.4% of PCOS subjects had hirsutism, primarily confined to the leg, arm and pubis. The PCOS population had higher serum luteinizing hormone (LH), LH : follicle stimulating hormone ratio, anti‐Mullerian hormone and testosterone. The PCOS population had double the ovarian volume compared to controls. PCOS subjects had no increase in metabolic disease history and had on average optimal serum markers for low metabolic disease risk. Group D (O + polycystic ovary morphology [PCOM]) was the most prevalent phenotype noted in our Vietnamese PCOS cohort (67.6%). Modified Ferriman–Gallwey, levels of LH, testosterone and anti‐Mullerian hormone were highest in Group A (O + H + PCOM) and lowest in Group D (O + PCOM).ConclusionThe Vietnamese PCOS population is characterized by a lean body type, nonfacial hirsutism, anovulatory, enlarged ovaries and typical PCOS serum hormone markers, low risk factors for metabolic syndrome. Nonclassical phenotypes for PCOS were more frequent than the classic phenotype.

Từ khóa


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Thông tin
Thông tin xuất bản

Journal of Obstetrics and Gynaecology Research

Tập 45 Số 11

2209-2219

Thông tin tác giả