Genetic markers for inherited thrombophilia are associated with fetal growth retardation in the population of Central Russia

Journal of Obstetrics and Gynaecology Research - Tập 43 Số 7 - Trang 1139-1144 - 2017
Evgeny Reshetnikov1, Oxana Zarudskaya1, Alexey Polonikov2, Olga Bushueva2, В. С. Орлова3, Evgeny N. Krikun4, Volodymyr Dvornyk5,6, Mikhail Churnosov1
1Department of Medical Biological Disciplines, Belgorod State University, Belgorod, Russia
2Department of Biology, Medical Genetics, and Ecology, Kursk State Medical University, Kursk, Russia
3Department of Obstetrics and Gynecology, Belgorod State University, Belgorod, Russia
4Medical College, Belgorod State University, Belgorod, Russia
5Department of Life Sciences, College of Science and General Studies, Alfaisal University, Saudi Arabia
6School of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong, China

Tóm tắt

AbstractAimThe aim of this study was to examine the role of hereditary thrombophilia in the development of fetal growth retardation (FGR) in the population of Central Russia.MethodsThe case–control study sample included 497 women in the third trimester of pregnancy recruited during 2009–2013. The participants were enrolled into two groups: patients with FGR (n = 250) and controls without FGR (n = 247). The participants were genotyped for four genetic markers of hereditary thrombophilia: factor V Leiden (G > A FV, rs6025), prothrombin (G > A FII, rs1799963), factor VII (G > A FVII, rs6046), and fibrinogen (G > A FI, rs1800790).ResultsThe genetic factors for an increased risk of FGR were allele G of rs6046 (odds ratio [OR] = 2.34) and genotype GG of rs6046 (OR = 2.64), whereas genotype GA of rs6046 had the protective value (OR = 0.42). A combination of alleles G of rs1799963, A of rs6046, and G of rs1800790 (OR = 0.31) reduces the risk of FGR.ConclusionPolymorphism rs6046 of the FVII gene is associated with the development of FGR.

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Journal of Obstetrics and Gynaecology Research

Tập 43 Số 7

1139-1144

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