Reproduction and Resistance to Stress: When and How Tập 15 Số 8 - Trang 711-724 - 2003
John C. Wingfield, RM Sapolsky
AbstractEnvironmental and social stresses have deleterious effects on
reproductive function in vertebrates. Global climate change, human disturbance
and endocrine disruption from pollutants are increasingly likely to pose
additional stresses that could have a major impact on human society.
Nonetheless, some populations of vertebrates (from fish to mammals) are able to
temporarily resist environmen... hiện toàn bộ
Neurodevelopmental and Neurophysiological Actions of Thyroid Hormone Tập 20 Số 6 - Trang 784-794 - 2008
Graham R. Williams
For over 100 years, thyroid hormones have been known to be essential for
neonatal neurodevelopment but whether they are required by the foetal brain
remains a matter of controversy. For decades, the prevailing view was that
thyroid hormones are not necessary until after birth because circulating levels
in the foetus are very low and the placenta forms an efficient barrier to their
transfer from th... hiện toàn bộ
Measurement of Immediate‐Early Gene Activation‐ c‐fos and Beyond Tập 20 Số 6 - Trang 665-672 - 2008
Krisztina Kovács
Immediate‐early genes (IEG) are powerful tools for identifying activated
neurosecretory neurones and extended circuits that affect neuroendocrine
functions. The generally acknowledged scenario is when cells became activated,
IEGs expressed and IEG‐encoded transcription factors affect target gene
expression. However, there are several examples in which: (i) neuronal
activation occurs without induct... hiện toàn bộ
Endocrine Disrupters: A Review of Some Sources, Effects, and Mechanisms of Actions on Behaviour and Neuroendocrine Systems Tập 24 Số 1 - Trang 144-159 - 2012
Cheryl A. Frye, Elisabetta Bo, Gemma Calamandrei, Laura Calzà, Francesco Dessì‐Fulgheri, Mercedes Fernández, Leonida Fusani, Olivier Kah, Małgorzata Kajta, Yann Le Page, Heather B. Patisaul, Aldina Venerosi, Anna K. Wójtowicz, Giancarlo Panzica
Some environmental contaminants interact with hormones and may exert adverse
consequences as a result of their actions as endocrine disrupting chemicals
(EDCs). Exposure in people is typically a result of contamination of the food
chain, inhalation of contaminated house dust or occupational exposure. EDCs
include pesticides and herbicides (such as dichlorodiphenyl trichloroethane or
its metabolite... hiện toàn bộ
Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABAA Receptors Tập 7 Số 3 - Trang 171-177 - 1995
Daniel Bitran, Michael Shiekh, Michael K. McLeod
AbstractPrevious studies from this laboratory have shown that progesterone
(PROG) treatment in ovariectomized rats produces an anti‐anxiety response
similar to that observed after the administration of prototypical anxiolytic
benzodiazepine (BDZ) compounds. The PROG‐induced anxiolytic response was highly
correlated with an increased level of 3α‐hydroxy‐5α‐pregnan‐20‐one
(allopregnanolone) in the b... hiện toàn bộ