Journal of Natural Medicines
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Longgu (Fossilia Ossis Mastodi) alters the profiles of organic and inorganic components in Keishikaryukotsuboreito
Journal of Natural Medicines - Tập 70 - Trang 483-491 - 2016
Longgu (Fossilia Ossis Mastodi) is a non-botanical crude drug, defined as “the
ossified bone of large mammal” in the Japanese Pharmacopoeia sixteenth edition
(JP16). It is a non-reproducible drug and is now facing the threat of
exhaustion. To solve this problem, we aimed to clarify the role of longgu in
Kampo prescriptions, which has not yet been scientifically ascertained. In this
study, we focus...
Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239
Journal of Natural Medicines - Tập 77 - Trang 516-522 - 2023
Alzheimer’s disease (AD) is an important human disease that mainly causes
cognitive impairments. Growing evidence has shown that amyloid-β (Aβ) peptide
plays a key role in AD pathogenesis in what is known as the Aβ cascade
hypothesis. This hypothesis suggests the importance of suppressing Aβ
aggregation and Aβ production. The latter process is governed by β-site APP
Cleaving Enzyme1 (BACE1) and γ-...
A new chalcone glycoside from Sapium sebiferum
Journal of Natural Medicines - Tập 61 - Trang 339-341 - 2007
A new chalcone glycoside, having an allenic ester moiety, was isolated together
with chalcononaringenin 2′-O-β-D-glucopyranoside from the catkin of Sapium
sebiferum. The structure elucidations of chalcone glycosides were based on the
analyses of spectroscopic data.
Quality evaluation of medicinally-used Codonopsis species and Codonopsis Radix based on the contents of pyrrolidine alkaloids, phenylpropanoid and polyacetylenes
Journal of Natural Medicines - Tập 68 - Trang 326-339 - 2013
A comparative study of 56 specimens of three medicinally-used Codonopsis taxa
collected from China and 54 commercial samples of Codonopsis Radix available in
Chinese, Japanese and Korean markets was carried out by quantitative analysis of
seven major components: codonopyrrolidium B (1), codonopyrrolidium A (2),
tangshenoside I (3), cordifolioidyne B (4), lobetyolinin (5), lobetyolin (6) and
lobety...
The sedative effect of inhaled terpinolene in mice and its structure–activity relationships
Journal of Natural Medicines - Tập 67 - Trang 833-837 - 2013
Terpinolene is a cyclic monoterpene compound found in some Labiatae herbs. In
our previous study, we evaluated the sedative effect of inhaled essential oils
of Microtoena patchoulii leaves in mice and isolated terpinolene as an active
ingredient. We investigated the structure–activity relationships of terpinolene
to identify the structural part essential to its sedative effect. Comparison of
terpi...
Species identification of Chinese medicinal plant Fallopia multiflora (Thunb.) Haraldson by suppression subtraction hybridization
Journal of Natural Medicines - Tập 68 - Trang 192-198 - 2013
Fallopia multiflora (Thunb.) Haraldson, a traditional Chinese medicinal plant,
has been extensively used in preparations of herbal medicine, health products
and personal hygiene products. However, the clinical safety and efficiency of F.
multiflora (Thunb.) Haraldson is impaired because of the existence of various
adulterants. In this study, genomic DNA (gDNA) suppression subtraction
hybridization...
Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum
Journal of Natural Medicines - - 2013
Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (II): apoptosis of antiproliferactive principle (24,25-dihydrowithanolide D) against ATL cell lines and structure–activity relationships with withanolides isolated from solanaceous plants
Journal of Natural Medicines - Tập 67 - Trang 415-420 - 2012
Adult T-cell leukemia/lymphoma (ATL) is an incurable peripheral T-cell
malignancy caused by human T-cell lymphotropic virus type I. In our preceding
paper, 214 extracts from 162 plants were screened to elucidate the
antiproliferative principles against ATL cell lines. Several withanolides were
isolated and the structure–activity relationships (SAR) examined. To extend the
search for SAR, 31 furthe...
Three new megastigmanes from the leaves of Annona muricata
Journal of Natural Medicines - Tập 66 - Trang 284-291 - 2011
Three new megastigmanes (1–3), named annoionols A and B (1, 2) and annoionoside
(3), were isolated from the leaves of Annona muricata L. (Annonaceae) together
with 14 known compounds (4–17). Among the known compounds, annoionol C (4) was
isolated from a natural source for the first time. The structures of all
compounds were elucidated by spectroscopic and chemical analyses.
Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid
Journal of Natural Medicines - Tập 70 - Trang 302-317 - 2016
5-Nor stemmadenine alkaloids, isolated from the genus Tabernaemontana, display a
range of bioactivity. 16-Hydroxy-16,22-dihydroapparicine, the active component
of an extract from the Tabernaemontana sp. (dichotoma, elegans, and divaricate),
exhibited potent antimalarial activity, representing the first such report of
the antimalarial property of 5-nor stemmadenine alkaloids. We, therefore,
decided...
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