Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloidJournal of Natural Medicines - Tập 70 - Trang 302-317 - 2016
Yoshihiko Noguchi, Tomoyasu Hirose, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, Toshiaki Sunazuka, Satoshi Ōmura
5-Nor stemmadenine alkaloids, isolated from the genus Tabernaemontana, display a range of bioactivity. 16-Hydroxy-16,22-dihydroapparicine, the active component of an extract from the Tabernaemontana sp. (dichotoma, elegans, and divaricate), exhibited potent antimalarial activity, representing the first such report of the antimalarial property of 5-nor stemmadenine alkaloids. We, therefore, decided...... hiện toàn bộ
In vitro and in vivo antiherpetic effects of (1R,2R)-1-(5′-methylful-3′-yl)propane-1,2,3-triolJournal of Natural Medicines - Tập 70 - Trang 217-224 - 2016
Kohei Sasaki, Kyoko Hayashi, Yuji Matsuya, Kenji Sugimoto, Jung-Bum Lee, Fumiya Kurosaki, Toshimitsu Hayashi
In this study, we demonstrated the in vitro and in vivo antiherpetic activities of a stable furan derivative, (1R,2R)-1-(5′-methylful-3′-yl)propane-1,2,3-triol (MFPT), which had originally been isolated from Streptomyces sp. strain FV60. In the present study, we synthesized MFPT from (5-methylfuran-3-yl)methanol in 6 steps for use in the experiments. MFPT showed potent in vitro antiviral activitie...... hiện toàn bộ
Quantification of terpene trilactones in Ginkgo biloba with a 1H NMR methodJournal of Natural Medicines - Tập 72 - Trang 793-797 - 2018
Tingfu Liang, Takuya Miyakawa, Jinwei Yang, Tsutomu Ishikawa, Masaru Tanokura
Ginkgo biloba L. has been used as a herbal medicine in the traditional treatment of insufficient blood flow, memory deficits, and cerebral insufficiency. The terpene trilactone components, the bioactive agents of Ginkgo biloba L., have also been reported to exhibit useful functionality such as anti-inflammatory and neuroprotective effects. Therefore, in the present research, we attempted to analyz...... hiện toàn bộ
Discrimination of Curcuma species from Asia using intron length polymorphism markers in genes encoding diketide-CoA synthase and curcumin synthaseJournal of Natural Medicines - Tập 76 - Trang 69-86 - 2021
Qundong Liu, Shu Zhu, Shigeki Hayashi, Osamu Iida, Akihito Takano, Katsunori Miyake, Suchada Sukrong, Mangestuti Agil, Indira Balachandran, Norio Nakamura, Nobuo Kawahara, Katsuko Komatsu
Recently, Curcuma rhizome-related foods with claimed health benefits have been used worldwide; however, correct identification and quality assessment have not been conducted. Due to the wide distribution and morphological similarities of Curcuma species, the classification of some species is debated and nomenclature is inconsistent among countries. In this study, to elucidate specific molecular ma...... hiện toàn bộ