Journal of Natural Medicines
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Longgu (Fossilia Ossis Mastodi) alters the profiles of organic and inorganic components in Keishikaryukotsuboreito
Journal of Natural Medicines - Tập 70 - Trang 483-491 - 2016
Longgu (Fossilia Ossis Mastodi) is a non-botanical crude drug, defined as “the ossified bone of large mammal” in the Japanese Pharmacopoeia sixteenth edition (JP16). It is a non-reproducible drug and is now facing the threat of exhaustion. To solve this problem, we aimed to clarify the role of longgu in Kampo prescriptions, which has not yet been scientifically ascertained. In this study, we focus......
Inhibition of Aβ aggregation by naphtho-γ-pyrone derivatives from a marine-derived fungus, Aspergillus sp. MPUC239
Journal of Natural Medicines - Tập 77 - Trang 516-522 - 2023
Alzheimer’s disease (AD) is an important human disease that mainly causes cognitive impairments. Growing evidence has shown that amyloid-β (Aβ) peptide plays a key role in AD pathogenesis in what is known as the Aβ cascade hypothesis. This hypothesis suggests the importance of suppressing Aβ aggregation and Aβ production. The latter process is governed by β-site APP Cleaving Enzyme1 (BACE1) and γ-......
A new chalcone glycoside from Sapium sebiferum
Journal of Natural Medicines - Tập 61 - Trang 339-341 - 2007
A new chalcone glycoside, having an allenic ester moiety, was isolated together with chalcononaringenin 2′-O-β-D-glucopyranoside from the catkin of Sapium sebiferum. The structure elucidations of chalcone glycosides were based on the analyses of spectroscopic data.
Quality evaluation of medicinally-used Codonopsis species and Codonopsis Radix based on the contents of pyrrolidine alkaloids, phenylpropanoid and polyacetylenes
Journal of Natural Medicines - Tập 68 - Trang 326-339 - 2013
A comparative study of 56 specimens of three medicinally-used Codonopsis taxa collected from China and 54 commercial samples of Codonopsis Radix available in Chinese, Japanese and Korean markets was carried out by quantitative analysis of seven major components: codonopyrrolidium B (1), codonopyrrolidium A (2), tangshenoside I (3), cordifolioidyne B (4), lobetyolinin (5), lobetyolin (6) and lobety......
The sedative effect of inhaled terpinolene in mice and its structure–activity relationships
Journal of Natural Medicines - Tập 67 - Trang 833-837 - 2013
Terpinolene is a cyclic monoterpene compound found in some Labiatae herbs. In our previous study, we evaluated the sedative effect of inhaled essential oils of Microtoena patchoulii leaves in mice and isolated terpinolene as an active ingredient. We investigated the structure–activity relationships of terpinolene to identify the structural part essential to its sedative effect. Comparison of terpi......
Species identification of Chinese medicinal plant Fallopia multiflora (Thunb.) Haraldson by suppression subtraction hybridization
Journal of Natural Medicines - Tập 68 - Trang 192-198 - 2013
Fallopia multiflora (Thunb.) Haraldson, a traditional Chinese medicinal plant, has been extensively used in preparations of herbal medicine, health products and personal hygiene products. However, the clinical safety and efficiency of F. multiflora (Thunb.) Haraldson is impaired because of the existence of various adulterants. In this study, genomic DNA (gDNA) suppression subtract......
Protein tyrosine phosphatase 1B inhibitory activity of Indonesian herbal medicines and constituents of Cinnamomum burmannii and Zingiber aromaticum
Journal of Natural Medicines - - 2013
Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (II): apoptosis of antiproliferactive principle (24,25-dihydrowithanolide D) against ATL cell lines and structure–activity relationships with withanolides isolated from solanaceous plants
Journal of Natural Medicines - Tập 67 - Trang 415-420 - 2012
Adult T-cell leukemia/lymphoma (ATL) is an incurable peripheral T-cell malignancy caused by human T-cell lymphotropic virus type I. In our preceding paper, 214 extracts from 162 plants were screened to elucidate the antiproliferative principles against ATL cell lines. Several withanolides were isolated and the structure–activity relationships (SAR) examined. To extend the search for SAR, 31 furthe......
Three new megastigmanes from the leaves of Annona muricata
Journal of Natural Medicines - Tập 66 - Trang 284-291 - 2011
Three new megastigmanes (1–3), named annoionols A and B (1, 2) and annoionoside (3), were isolated from the leaves of Annona muricata L. (Annonaceae) together with 14 known compounds (4–17). Among the known compounds, annoionol C (4) was isolated from a natural source for the first time. The structures of all compounds were elucidated by spectroscopic and chemical analyses.
Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid
Journal of Natural Medicines - Tập 70 - Trang 302-317 - 2016
5-Nor stemmadenine alkaloids, isolated from the genus Tabernaemontana, display a range of bioactivity. 16-Hydroxy-16,22-dihydroapparicine, the active component of an extract from the Tabernaemontana sp. (dichotoma, elegans, and divaricate), exhibited potent antimalarial activity, representing the first such report of the antimalarial property of 5-nor stemmadenine alkaloids. We, therefore, decided......
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