Journal of Molecular Histology

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DLK1 overexpression improves sepsis-induced cardiac dysfunction and fibrosis in mice through the TGF-β1/Smad3 signaling pathway and MMPs
Journal of Molecular Histology - Tập 54 Số 6 - Trang 655-664 - 2023
Ni Zeng, Zaijin Jian, Junmei Xu, Sijia Zheng, Yongmei Fan, Feng Xiao
NFIC promotes the vitality and osteogenic differentiation of rat dental follicle cells
Journal of Molecular Histology - Tập 50 - Trang 471-482 - 2019
Fuping Zhang, Min Liang, Chuanjiang Zhao, Yun Fu, Shaojie Yu
Nuclear factor I-C (NFIC) plays critical roles in the regulation of tooth development by influencing the biological behaviors of stem cells in the dental germ. This study aimed to investigate the effect of NFIC on the vitality and osteogenic/cementogenic differentiation of rat dental follicle cells (DFCs). DFCs were isolated from dental follicles in the first molars of neonatal rats. DFCs expresse...... hiện toàn bộ
Co-expression of interleukin-6 and human growth hormone in apparently normal prostate biopsies that ultimately progress to prostate cancer using low pH, high temperature antigen retrieval
Journal of Molecular Histology - Tập 37 - Trang 37-41 - 2006
M. D. Slater, C. R. Murphy
Prostate cancer is the most common cancer in American men and the second leading cause of cancer deaths in this group. Both growth hormone (GH) and the inflammatory cytokine interleukin 6 (IL-6) have been implicated in prostate cancer progression. Studies in other systems have shown that an increase in GH results in an increase in IL-6 also. The current study demonstrated a parallel spatial and te...... hiện toàn bộ
Tác dụng bảo vệ của lycopene đối với chức năng tim và xơ hóa cơ tim sau nhồi máu cơ tim cấp tính ở chuột theo cơ chế điều chỉnh p38 và MMP-9 Dịch bởi AI
Journal of Molecular Histology - Tập 45 - Trang 113-120 - 2013
Xin Wang, Hong Lv, Yongwei Gu, Xi Wang, Hong Cao, Yanhong Tang, Hui Chen, Congxin Huang
Ma trận ngoại bào (ECM) đóng vai trò quan trọng trong việc duy trì hình dạng và chức năng của thất trái, và việc ức chế tái cấu trúc ECM có những lợi ích điều trị giúp giảm tiến triển của tái cấu trúc thất. Các nghiên cứu gần đây cho thấy lycopene có tác dụng bảo vệ tim. Trong nghiên cứu này, một mô hình nhồi máu cơ tim (MI) ở chuột đã được thiết lập bằng cách thắt động mạch vành bên trái xuống. S...... hiện toàn bộ
#lycopene #nhồi máu cơ tim #chức năng tim #xơ hóa cơ tim #MMP-9 #p38
Fascin promotes the invasion of pituitary adenoma through partial dependence on epithelial–mesenchymal transition
Journal of Molecular Histology - - 2021
Hong You, Jian Xu, Xiaochun Qin, Guodong Qian, Yang Wang, Fulei Chen, Xiaoxu Shen, Dong Zhao, Qi Liu
The heparan sulphate deficient Hspg2 exon 3 null mouse displays reduced deposition of TGF-β1 in skin compared to C57BL/6 wild type mice
Journal of Molecular Histology - Tập 47 Số 3 - Trang 365-374 - 2016
Cindy Shu, Susan Smith, James Melrose
The expression pattern of ADP-ribosyltransferase 3 in rat traumatic brain injury
Journal of Molecular Histology - Tập 43 - Trang 37-47 - 2011
Wei Shi, Peipei Gong, Jian Fan, Yao Hua Yan, Lanchun Ni, Xiaohong Wu, Gang Cui, Xinmin Wu, Xingxing Gu, Jian Chen
Mammalian ecto ADP-ribosyltransferases (ARTs) can regulate the biological functions of various types of cells by catalyzing the transfer of single ADP-ribose moiety from NAD+ to a specific amino acid in a target protein. ART3 is a member of the known ART family which is involved in cell division, DNA-repair and the regulation of the inflammatory response. To elucidate the expression, cellular loca...... hiện toàn bộ
Downregulation of the long noncoding RNA TUG1 inhibits the proliferation, migration, invasion and promotes apoptosis of renal cell carcinoma
Journal of Molecular Histology - Tập 47 Số 4 - Trang 421-428 - 2016
Meng Zhang, Wei Lu, Yi Huang, Jizhou Shi, Xun Wu, Xiaolong Zhang, Runze Jiang, Zhiming Cai, Song Wu
Overexpression of insulin receptor substrate-4 is correlated with clinical staging in colorectal cancer patients
Journal of Molecular Histology - Tập 49 - Trang 39-49 - 2017
Patricia Sanmartín-Salinas, M. Val Toledo-Lobo, Fernando Noguerales-Fraguas, María-Encarnación Fernández-Contreras, Luis G. Guijarro
Insulin receptor substrate-4 (IRS-4), a poorly studied member of the IRS family, may play an important role in colorectal cancer (CRC) tumourigenesis. The aim of this pilot study was to elucidate the potential role of IRS-4 in colorectal carcinogenesis by evaluating IRS-4 expression in different types of colorectal tumours (n = 20) and comparing its expression to normal mucosa (n = 20). Tissue sam...... hiện toàn bộ
The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer
Journal of Molecular Histology - Tập 37 - Trang 301-307 - 2006
Markus Seifert, Jörg Reichrath
The cellular DNA mismatch repair (MMR) pathway, involving the DNA mismatch repair genes MLH1 and MSH2, detects and repairs DNA replication errors. Defects in MSH2 and MLH1 account for most cases of hereditary non-polyposis colorectal cancer as well as for sporadic colorectal tumors. Additionally, increased expression of MSH2 RNA and/or protein has been reported in various malignancies. Loss of DNA...... hiện toàn bộ
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