Journal of Immunology

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1β Secretion through the NLRP3 Inflammasome In Vitro
Journal of Immunology - Tập 186 Số 4 - Trang 2495-2502 - 2011
Borbála Pazár, Jean‐Claude Roujeau, Sharmal Narayan, Laeticia Kolly, Nathalie Bagnoud, Véronique Chobaz, Thierry Roger, Frédéric Lioté, Alexander So, Nathalie Busso
Abstract Basic calcium phosphate (BCP) crystals are associated with severe osteoarthritis and acute periarticular inflammation. Three main forms of BCP crystals have been identified from pathological tissues: octacalcium phosphate, carbonate-substituted apatite, and hydroxyapatite. We investigated the proinflammatory effects of these BCP crystals in ...... hiện toàn bộ
B Cell Clonal Expansion and Somatic Hypermutation of Ig Variable Heavy Chain Genes in the Synovial Membrane of Patients with Osteoarthritis
Journal of Immunology - Tập 178 Số 1 - Trang 557-565 - 2007
Reng-Rong Da, Yingzhi Qin, Dominique Baeten, Yiping Zhang
Abstract Inflammatory mediators have been explored as possible factors in the initiation and/or progression of osteoarthritis (OA). This study shows that synovial infiltration by B lymphocytes is present in almost half of the knee OA cases. The degree of B lymphocyte infiltration is associated with more pronounced synovial inflammation and with the p...... hiện toàn bộ
Nucleocytoplasmic Shuttling of HMGB1 Is Regulated by Phosphorylation That Redirects It toward Secretion
Journal of Immunology - Tập 177 Số 11 - Trang 7889-7897 - 2006
Ju Ho Youn, Jeon‐Soo Shin
Abstract The high mobility group box 1 (HMGB1) protein can be secreted by activated monocytes and macrophages and functions as a late mediator of sepsis. HMGB1 contains two nuclear localization signals (NLSs) for controlled nuclear transport, and acetylation of both NLSs of HMGB1 is involved in nuclear transport toward secretion. However, phosphoryla...... hiện toàn bộ
Heat Shock Protein 70 Is Secreted from Tumor Cells by a Nonclassical Pathway Involving Lysosomal Endosomes
Journal of Immunology - Tập 177 Số 11 - Trang 7849-7857 - 2006
Salamatu S. Mambula, Stuart K. Calderwood
AbstractHeat shock protein (HSP)70 can be released from tumor cells and stimulate a potent antitumor immune response. However, HSP70 does not contain a consensus secretory signal and thus cannot traverse the plasma membrane by conventional mechanisms. We have observed HSP70 release from intact human prostate carcinoma cell lines (PC-3 and LNCaP) by a mechanism inde...... hiện toàn bộ
Mac-1, but Not LFA-1, Uses Intercellular Adhesion Molecule-1 to Mediate Slow Leukocyte Rolling in TNF-α-Induced Inflammation
Journal of Immunology - Tập 171 Số 11 - Trang 6105-6111 - 2003
Jessica L. Dunne, Robert G. Collins, Arthur L. Beaudet, Christie M. Ballantyne, Klaus Ley
AbstractWe have previously shown that Mac-1 and LFA-1 play a cooperative role in slow leukocyte rolling in inflamed vessels, and that, although both have a role in leukocyte adhesion, the contribution from LFA-1 exceeds that of Mac-1. In this study, we used mice deficient in ICAM-1 (ICAM-1null) to study the function of ICAM-1 as an endothelial ligand for Mac-1 and ...... hiện toàn bộ
Processing of engulfed apoptotic bodies yields T cell epitopes.
Journal of Immunology - Tập 159 Số 11 - Trang 5391-5399 - 1997
Matteo Bellone, Giandomenica Iezzi, Patrizia Rovere, Giacomo Galati, Anna Ronchetti, Maria Pia Protti, Jean Davoust, C Rugarli, A A Manfredi
Abstract Programmed death via apoptosis is the metazoan physiologic mode of cell death. Apoptotic cells are recognized by scavenger phagocytes via a number of membrane receptors and engulfed. Thereafter, little is known of their fate, or that of phagocytes. Here, we have traced apoptotic cells upon their engulfment by macrophages. After 3 h, apoptoti...... hiện toàn bộ
Expression, Linkage, and Polymorphism of MHC-Related Genes in Rainbow Trout,Oncorhynchus mykiss
Journal of Immunology - Tập 163 Số 2 - Trang 774-786 - 1999
John D. Hansen, Pamela Strassburger, Gary H. Thorgaard, William P. Young, Louis Du Pasquier
AbstractThe architecture of the MHC in teleost fish, which display a lack of linkage between class I and II genes, differs from all other vertebrates. Because rainbow trout have been examined for a variety of immunologically relevant genes, they present a good teleost model for examining both the expression and organization of MHC-related genes. Full-length cDNA an...... hiện toàn bộ
TIM-3 Regulates Innate Immune Cells To Induce Fetomaternal Tolerance
Journal of Immunology - Tập 190 Số 1 - Trang 88-96 - 2013
Lola Chabtini, Bechara Mfarrej, Marwan Mounayar, Bing Zhu, Ibrahim Batal, Pranal J. Dakle, Brian D. Smith, Olaf Boenisch, Nader Najafian, Hisaya Akiba, Hideo Yagita, Indira Guleria
Abstract TIM-3 is constitutively expressed on subsets of macrophages and dendritic cells. Its expression on other cells of the innate immune system and its role in fetomaternal tolerance has not yet been explored. In this study, we investigate the role of TIM-3–expressing innate immune cells in the regulation of tolerance at the fetomaternal interfac...... hiện toàn bộ
Myeloid-Derived Suppressor Cells Regulate Immune Response in Patients with Chronic Hepatitis B Virus Infection through PD-1–Induced IL-10
Journal of Immunology - Tập 193 Số 11 - Trang 5461-5469 - 2014
Ang Huang, Bo Zhang, Weiwei Yan, Bo Wang, Huafeng Wei, Fan Zhang, Lang Wu, Kexing Fan, Yajun Guo
Abstract Although myeloid-derived suppressor cells (MDSCs) are well known for their immunosuppressive function in several pathological conditions, the role of MDSCs in hepatitis B virus infection remains obscure. In this study, we investigated the frequency and function of MDSCs in the peripheral blood and liver of 91 chronic hepatitis B (CHB) patien...... hiện toàn bộ
Humoral response to a carboxyl-terminal region of the merozoite surface protein-1 plays a predominant role in controlling blood-stage infection in rodent malaria.
Journal of Immunology - Tập 155 Số 1 - Trang 236-243 - 1995
T M Daly, Carol A. Long
Abstract The developmental stages of malaria parasites that infect E are responsible for the morbidity and mortality associated with this disease. One of the leading candidates for a blood-stage vaccine against malaria is a surface protein of merozoites, the infectious stages for E, designated merozoite surface protein-1 (MSP-1). The rodent malarial ...... hiện toàn bộ
Tổng số: 2,039   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10