Journal of Immunology
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Antibodies to Guinea Pig LymphokinesAbstract
It was shown previously, that an antiserum directed against highly purified fractions of migration inhibitory factor inhibits delayed hypersensitivity reactions in vivo and in vitro. Using radiolabeling techniques we determined that the anti-lymphokine serum reacted primarily with three lymphocyte activation products (m.w. 60,000, 45,000, an... ... hiện toàn bộ
Journal of Immunology - Tập 121 Số 3 - Trang 1199-1205 - 1978
Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity.Abstract
Humans chronically infected with schistosomiasis usually have impaired parasite Ag-specific lymphocyte proliferation and IFN-gamma production that may facilitate persistence of the parasite while producing little clinical disease. The mechanisms that contribute to the immunologic hyporesponsiveness in these patients remain undefined. IL-10 h... ... hiện toàn bộ
Journal of Immunology - Tập 156 Số 12 - Trang 4715-4721 - 1996
Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells.Abstract
Mice genetically deficient in IL-7R(alpha) are highly lymphopenic in the peripheral lymphoid organs. The functional competence of T cells that have developed in the absence of an IL-7R signal was investigated. Three important observations were made using several in vitro activation regimens. First, stimulation of T cells from IL-7R -/- mice ... ... hiện toàn bộ
Journal of Immunology - Tập 157 Số 12 - Trang 5315-5323 - 1996
Secretory Phospholipases A2 Induce β-Glucuronidase Release and IL-6 Production from Human Lung MacrophagesAbstract Secretory phospholipases A2 (sPLA2s) are a group of extracellular enzymes that release fatty acids at the sn-2 position of phospholipids. Group IIA sPLA2 has been detected in inflammatory fluids, and its plasma level is increased in inflammatory diseases. To investigate a potential mechanism of sPLA2-induced inflammation we studied the effect of group IA (f... ... hiện toàn bộ
Journal of Immunology - Tập 164 Số 9 - Trang 4908-4915 - 2000
Listeria monocytogenesInfection Overcomes the Requirement for CD40 Ligand in Exogenous Antigen Presentation to CD8+ T CellsAbstract In vivo priming of CD8+ T lymphocytes against exogenously processed model Ags requires CD4+ T cell help, specifically interactions between CD40 ligand (CD40L) expressed by activated CD4+ T cells and CD40, which is present on professional APC such as dendritic cells (DCs). To address this issue in the context of bacterial infection, we examined CD40L-CD40 in... ... hiện toàn bộ
Journal of Immunology - Tập 167 Số 10 - Trang 5603-5609 - 2001
B Lymphocytes as Antigen-Presenting Cells for CD4+ T Cell Priming In VivoAbstract
The contribution of B lymphocytes as APCs for CD4+ T cell priming remains controversial, based on findings that B cells cannot provide the requisite ligating and costimulatory signals for naive T cells to be activated. In the current study, we have examined Ag-specific T:B cell collaboration under circumstances in which B cells take up Ag th... ... hiện toàn bộ
Journal of Immunology - Tập 162 Số 10 - Trang 5695-5703 - 1999
Stabilization of Foxp3 by Targeting JAK2 Enhances Efficacy of CD8 Induced Regulatory T Cells in the Prevention of Graft-versus-Host Disease.
Journal of Immunology - Tập 201 Số 9 - Trang 2812-2823 - 2018
CD8+ induced regulatory T cells (iTregs) have been identified to suppress alloreactive immune responses and expressed regulatory T cell (Treg) ontological markers as similar as CD4+ iTregs. However, adoptive transfer of CD8+ iTreg-based therapy is hampered by the instability of Treg specific-transcription factor, Foxp3. As CD8+ iTregs were previously demonstrated to possess superior tumor-killing ...... hiện toàn bộ
Stabilization of Foxp3 by Targeting JAK2 Enhances Efficacy of CD8 Induced Regulatory T Cells in the Prevention of Graft-versus-Host Disease.
Journal of Immunology - - 2018
CD8+ induced regulatory T cells (iTregs) have been identified to suppress alloreactive immune responses and expressed regulatory T cell (Treg) ontological markers as similar as CD4+ iTregs. However, adoptive transfer of CD8+ iTreg-based therapy is hampered by the instability of Treg specific-transcription factor, Foxp3. As CD8+ iTregs were previously demonstrated to possess superior tumor-killing ...... hiện toàn bộ
Protective role of IgE in immunocompromised rat toxoplasmosis.Abstract
In contrast to euthymic adult Fischer rats, immunocompromised Nu/Nu animals develop a lethal infection when inoculated with the RH strain of the protozoan Toxoplasma gondii. However, a significant period of survival is obtained when Nu/Nu rats are passively transferred with sera from 28-day infected Fischer +/+ (euthymic) animals. Specific I... ... hiện toàn bộ
Journal of Immunology - Tập 141 Số 3 - Trang 978-983 - 1988
Agonist-dependent phosphorylation of N-formylpeptide and activation peptide from the fifth component of C (C5a) chemoattractant receptors in differentiated HL60 cells.Abstract
Attenuation of signaling is a key step in controlling the cytotoxic potential of leukocyte responses to chemotactic factors. Antipeptide antibodies, directed against the N-formyl chemotactic peptide receptor (FPR) and the activation peptide from the fifth component of C (C5a) anaphylatoxin receptor (C5aR) of human neutrophils, were used to a... ... hiện toàn bộ
Journal of Immunology - Tập 150 Số 8 - Trang 3534-3545 - 1993
Tổng số: 2,038
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