Journal of Immunology

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Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1β Secretion through the NLRP3 Inflammasome In Vitro
Journal of Immunology - Tập 186 Số 4 - Trang 2495-2502 - 2011
Borbála Pazár, Jean‐Claude Roujeau, Sharmal Narayan, Laeticia Kolly, Nathalie Bagnoud, Véronique Chobaz, Thierry Roger, Frédéric Lioté, Alexander So, Nathalie Busso
Abstract Basic calcium phosphate (BCP) crystals are associated with severe osteoarthritis and acute periarticular inflammation. Three main forms of BCP crystals have been identified from pathological tissues: octacalcium phosphate, carbonate-substituted apatite, and hydroxyapatite. We investigated the proinflammatory effects of these BCP crystals in ...... hiện toàn bộ
Herpesvirus-Specific CD8 T Cell Immunity in Old Age: Cytomegalovirus Impairs the Response to a Coresident EBV Infection
Journal of Immunology - Tập 173 Số 12 - Trang 7481-7489 - 2004
Naeem Khan, Andrew D. Hislop, Nancy Gudgeon, Mark Cobbold, Rajiv Khanna, Laxman Nayak, Alan B. Rickinson, Paul Moss
Abstract Aging in humans is associated with increased infections and the reduced proliferative capacity of T cells, part of the more global phenomenon termed immune senescence. The etiology of immune senescence is unknown but the accumulation of virus-specific memory T cells may be a contributory factor. We have examined CD8 T cell responses to two p...... hiện toàn bộ
A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency.
Journal of Immunology - Tập 153 Số 4 - Trang 1687-1696 - 1994
Peihua Lu, Robert S. Negrin
Abstract Recently, we have reported a novel protocol for the generation of highly efficient cytotoxic effector cells by culturing PBLs in the presence of IFN-gamma, IL-2, mAb against CD3, and IL-1 alpha. We have termed these cultures cytokine-induced killer (CIK) cells because the phenotype of the cells with the greatest cytotoxicity expresses both t...... hiện toàn bộ
B Cell Clonal Expansion and Somatic Hypermutation of Ig Variable Heavy Chain Genes in the Synovial Membrane of Patients with Osteoarthritis
Journal of Immunology - Tập 178 Số 1 - Trang 557-565 - 2007
Reng-Rong Da, Yingzhi Qin, Dominique Baeten, Yiping Zhang
Abstract Inflammatory mediators have been explored as possible factors in the initiation and/or progression of osteoarthritis (OA). This study shows that synovial infiltration by B lymphocytes is present in almost half of the knee OA cases. The degree of B lymphocyte infiltration is associated with more pronounced synovial inflammation and with the p...... hiện toàn bộ
Nucleocytoplasmic Shuttling of HMGB1 Is Regulated by Phosphorylation That Redirects It toward Secretion
Journal of Immunology - Tập 177 Số 11 - Trang 7889-7897 - 2006
Ju Ho Youn, Jeon‐Soo Shin
Abstract The high mobility group box 1 (HMGB1) protein can be secreted by activated monocytes and macrophages and functions as a late mediator of sepsis. HMGB1 contains two nuclear localization signals (NLSs) for controlled nuclear transport, and acetylation of both NLSs of HMGB1 is involved in nuclear transport toward secretion. However, phosphoryla...... hiện toàn bộ
Heat Shock Protein 70 Is Secreted from Tumor Cells by a Nonclassical Pathway Involving Lysosomal Endosomes
Journal of Immunology - Tập 177 Số 11 - Trang 7849-7857 - 2006
Salamatu S. Mambula, Stuart K. Calderwood
AbstractHeat shock protein (HSP)70 can be released from tumor cells and stimulate a potent antitumor immune response. However, HSP70 does not contain a consensus secretory signal and thus cannot traverse the plasma membrane by conventional mechanisms. We have observed HSP70 release from intact human prostate carcinoma cell lines (PC-3 and LNCaP) by a mechanism inde...... hiện toàn bộ
IgE Synthesis in Man
Journal of Immunology - Tập 118 Số 1 - Trang 334-341 - 1977
James Nagel, Dianna Svec, Tomi Waters, Philip Fireman
Abstract Specific IgE and IgG antibodies were measured in 39 adolescent and adult humans preselected to have less than 0.125 antitoxin units (AU) ml of tetanus antitoxin (IgG) irrespective of previous immunization history. Mean antitoxin values (IgG) measured by sheep red cell hemagglutination (SRBC) increased by 2 logs to 1.49 AU/ml sera for tetanus...... hiện toàn bộ
B Cell–Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle
Journal of Immunology - Tập 200 Số 3 - Trang 937-948 - 2018
Meijie Tian, Zhaolin Hua, Hong Sheng, Zhimin Zhang, Can Liu, Lin Lin, Jiaorong Chen, Wei Zhang, Xuyu Zhou, Fuping Zhang, Anthony DeFranco, Baidong Hou
Abstract Although TLR signaling in B cells has been implicated in the germinal center (GC) responses during viral infections and autoimmune diseases, the underlying mechanism is unclear. Bacterial phage Qβ-derived virus-like particle (Qβ-VLP) contains TLR ligands, which can enhance Qβ-VLP-induced Ab response, including GC response, through TLR/MyD88 ...... hiện toàn bộ
Induction of Antitumor Immunity with Dendritic Cells Transduced with Adenovirus Vector-Encoding Endogenous Tumor-Associated Antigens
Journal of Immunology - Tập 163 Số 2 - Trang 699-707 - 1999
Johanne Kaplan, Queendy Yu, Susan Piraino, Sarah Pennington, Srinivas Shankara, Lisa Woodworth, Bruce Roberts
AbstractDendritic cells (DCs) are professional Ag-presenting cells that are being considered as potential immunotherapeutic agents to promote host immune responses against tumor Ags. In this study, recombinant adenovirus (Ad) vectors encoding melanoma-associated Ags were used to transduce murine DCs, which were then tested for their ability to activate CTL and indu...... hiện toàn bộ
IL-4 in the Brain: A Cytokine To Remember
Journal of Immunology - Tập 189 Số 9 - Trang 4213-4219 - 2012
Sachin P. Gadani, James C. Cronk, Geoffrey T. Norris, Jonathan Kipnis
Abstract IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this cytokine appea...... hiện toàn bộ
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