Journal of Immunology
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Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1β Secretion through the NLRP3 Inflammasome In Vitro
Journal of Immunology - Tập 186 Số 4 - Trang 2495-2502 - 2011
Abstract Basic calcium phosphate (BCP) crystals are associated with severe
osteoarthritis and acute periarticular inflammation. Three main forms of BCP
crystals have been identified from pathological tissues: octacalcium phosphate,
carbonate-substituted apatite, and hydroxyapatite. We investigated the
proinflammatory effects of these BCP crystals in vitro with special regard to
the involvement of ...
Herpesvirus-Specific CD8 T Cell Immunity in Old Age: Cytomegalovirus Impairs the Response to a Coresident EBV Infection
Journal of Immunology - Tập 173 Số 12 - Trang 7481-7489 - 2004
Abstract Aging in humans is associated with increased infections and the reduced
proliferative capacity of T cells, part of the more global phenomenon termed
immune senescence. The etiology of immune senescence is unknown but the
accumulation of virus-specific memory T cells may be a contributory factor. We
have examined CD8 T cell responses to two persistent herpesvirus infections, CMV
and EBV, a...
A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency.
Journal of Immunology - Tập 153 Số 4 - Trang 1687-1696 - 1994
Abstract Recently, we have reported a novel protocol for the generation of
highly efficient cytotoxic effector cells by culturing PBLs in the presence of
IFN-gamma, IL-2, mAb against CD3, and IL-1 alpha. We have termed these cultures
cytokine-induced killer (CIK) cells because the phenotype of the cells with the
greatest cytotoxicity expresses both the T cell marker CD3 and the NK cell
marker CD56...
B Cell Clonal Expansion and Somatic Hypermutation of Ig Variable Heavy Chain Genes in the Synovial Membrane of Patients with Osteoarthritis
Journal of Immunology - Tập 178 Số 1 - Trang 557-565 - 2007
Abstract Inflammatory mediators have been explored as possible factors in the
initiation and/or progression of osteoarthritis (OA). This study shows that
synovial infiltration by B lymphocytes is present in almost half of the knee OA
cases. The degree of B lymphocyte infiltration is associated with more
pronounced synovial inflammation and with the presence of plasma cells and
lymphoid follicles i...
Nucleocytoplasmic Shuttling of HMGB1 Is Regulated by Phosphorylation That Redirects It toward Secretion
Journal of Immunology - Tập 177 Số 11 - Trang 7889-7897 - 2006
Abstract The high mobility group box 1 (HMGB1) protein can be secreted by
activated monocytes and macrophages and functions as a late mediator of sepsis.
HMGB1 contains two nuclear localization signals (NLSs) for controlled nuclear
transport, and acetylation of both NLSs of HMGB1 is involved in nuclear
transport toward secretion. However, phosphorylation of HMGB1 and its relation
to nuclear transp...
Heat Shock Protein 70 Is Secreted from Tumor Cells by a Nonclassical Pathway Involving Lysosomal Endosomes
Journal of Immunology - Tập 177 Số 11 - Trang 7849-7857 - 2006
AbstractHeat shock protein (HSP)70 can be released from tumor cells and
stimulate a potent antitumor immune response. However, HSP70 does not contain a
consensus secretory signal and thus cannot traverse the plasma membrane by
conventional mechanisms. We have observed HSP70 release from intact human
prostate carcinoma cell lines (PC-3 and LNCaP) by a mechanism independent of de
novo HSP70 synthesi...
IgE Synthesis in Man
Journal of Immunology - Tập 118 Số 1 - Trang 334-341 - 1977
Abstract Specific IgE and IgG antibodies were measured in 39 adolescent and
adult humans preselected to have less than 0.125 antitoxin units (AU) ml of
tetanus antitoxin (IgG) irrespective of previous immunization history. Mean
antitoxin values (IgG) measured by sheep red cell hemagglutination (SRBC)
increased by 2 logs to 1.49 AU/ml sera for tetanus and by 1 log to 0.025 AU/ml
sera for diphtheria...
B Cell–Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle
Journal of Immunology - Tập 200 Số 3 - Trang 937-948 - 2018
Abstract Although TLR signaling in B cells has been implicated in the germinal
center (GC) responses during viral infections and autoimmune diseases, the
underlying mechanism is unclear. Bacterial phage Qβ-derived virus-like particle
(Qβ-VLP) contains TLR ligands, which can enhance Qβ-VLP-induced Ab response,
including GC response, through TLR/MyD88 signaling in B cells. In this study, by
examinin...
Induction of Antitumor Immunity with Dendritic Cells Transduced with Adenovirus Vector-Encoding Endogenous Tumor-Associated Antigens
Journal of Immunology - Tập 163 Số 2 - Trang 699-707 - 1999
AbstractDendritic cells (DCs) are professional Ag-presenting cells that are
being considered as potential immunotherapeutic agents to promote host immune
responses against tumor Ags. In this study, recombinant adenovirus (Ad) vectors
encoding melanoma-associated Ags were used to transduce murine DCs, which were
then tested for their ability to activate CTL and induce protective immunity
against B1...
IL-4 in the Brain: A Cytokine To Remember
Journal of Immunology - Tập 189 Số 9 - Trang 4213-4219 - 2012
Abstract IL-4 has been extensively studied in the context of its role in
immunity. Accumulating evidence indicates, however, that it also plays a
critical role in higher functions of the normal brain, such as memory and
learning. In this review, we summarize current knowledge of the basic immunology
of IL-4, describe how and where this cytokine appears to operate in normal brain
function, and prop...
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