Bio-diagnostic performances of microRNAs set related to DNA damage response pathway among hepatitis C virus-associated hepatocellular carcinoma patientsJournal of Genetic Engineering and Biotechnology - Tập 21 - Trang 1-11 - 2023
Sara M. Abdo, Wafaa Gh. Shousha, Amal Ahmed Mohamed, Mohamed Elshobaky, Mohamed Saleh, Mostafa Mohamed Abdelhamid Ali
Up to date, a well-defined microRNAs (miRNAs) profile involved in hepatocellular carcinoma (HCC) pathogenesis remains indecisive. Thus, employing miRNAs for HCC diagnosis is demanded for early therapeutic interventions. We aimed to evaluate the usage of miRNAs set related to the SuperPath: miRNAs involved in DNA damage response pathway as effective biomarkers for HCV-related HCC diagnosis. The stu...... hiện toàn bộ
Genetic diversity analysis of some Egyptian Origanum and Thymus species using AFLP markersJournal of Genetic Engineering and Biotechnology - - 2019
El-Shaimaa Saad El-Demerdash, Esraa Attia Elsherbeny, Yasser Abdelhakim Mohamed Salama, Mohamed Zoelfakar Ahmed
In the present investigation, two genera of family Labiatae (genus Origanum and genus Thymus including their available species in Egypt) were analyzed genetically on DNA level using amplified fragment length polymorphism (AFLP) markers. Four selective primer combinations (E-AGC/M-CAA, E-AGC/M-CAC, E-AGG/M-CTC, and E-ACC/M-CAT) were used to detect genetic variations (polymorphisms) within and betwe...... hiện toàn bộ
In silico multi-epitope Bunyumwera virus vaccine to target virus nucleocapsid N proteinJournal of Genetic Engineering and Biotechnology - Tập 20 - Trang 1-13 - 2022
Kanaka Durga Devi Nelluri, Manne Anupama Ammulu, M. Lakshmi Durga, Melika Sravani, Vemuri Praveen Kumar, Sudhakar Poda
Bunyumwera virus can cause 82% mortality in humans currently with no vaccine or drugs for treatment. We described an in silico multi-epitope vaccine targeting Bunyumwera virus nucleocapsid N-protein and predicted B and T cell epitopes for immunogenicity, allergenicity, toxicity, and conservancy. For creating the most potent immunological response possible, docking epitopes with HLA alleles are cho...... hiện toàn bộ
Molecular docking unveils the potential of andrographolide derivatives against COVID-19: an in silico approachJournal of Genetic Engineering and Biotechnology - Tập 20 - Trang 1-16 - 2022
Ravichandran Veerasamy, Rohini Karunakaran
The recent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection cause high mortality and there is an emergency need to develop a specific drug to treat the novel coronavirus disease, COVID-19. However, some natural and synthetic products with action against SARS-CoV-2 have been reported in recent research, there is no specific drug available for treating COVID-19. In the present ...... hiện toàn bộ
Genetic variations in Turkey cultivar and ecotype Medicago sativa species: cytological, total protein profile, and molecular characterizationJournal of Genetic Engineering and Biotechnology - Tập 19 - Trang 1-11 - 2021
Büşra Yazıcılar, Gholamreza Jannati, Ismail Bezirganoglu
Alfalfa (Medicago sativa L.) is a perennial plant, which is high in nutritional value and resistant to environmental conditions, and it is one of most frequently preferred feed crop among the leguminous family. In this study, it was aimed to determine the genetic diversity of some alfalfa ecotypes and their varieties by DNA, protein, nucleus, and chromosome counts. The genetic distance between the...... hiện toàn bộ
Identification of conserved miRNAs and their targets in Jatropha curcas: an in silico approachJournal of Genetic Engineering and Biotechnology - Tập 21 - Trang 1-15 - 2023
Foeaz Ahmed, Md. Nazmul Islam Bappy, Md. Shariful Islam
MicroRNAs (miRNAs) are small endogenous RNAs with an approximate length of 18–22 nucleotides and involved in the regulation of gene expression in transcriptional or post-transcriptional levels. They were found to be associated with leaf morphogenesis, flowering time, vegetative phase change, and response to environmental cues in plants, where they act as a critical regulatory factor. The nature of...... hiện toàn bộ