Journal of Flow Chemistry
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Continuous synthesis of tetraethyl thiuram disulfide with CO2 as acid agent in a gas-liquid microdispersion system
Journal of Flow Chemistry - Tập 9 - Trang 211-220 - 2019
Herein, a continuous synthetic method of tetraethyl thiuram disulfide (TETD) with CO2 as a weak acid reagent in a gas-liquid microdispersion reaction system has been described. A microdispersion reaction system comprising two microreactors for CO2 absorption and diethyldithiocarbamate acid subsequent oxidation reaction was developed. In the first step, the main products of absorption and oxidation......
Generation and Reactions of Vinyllithiums Using Flow Microreactor Systems
Journal of Flow Chemistry - Tập 2 - Trang 70-72 - 2012
Vinyllithiums were effectively generated by bromine-lithium exchange reaction of vinyl bromides with one eq of s-BuLi in a flow microreactor system at 0 °C or 20 °C, although two eq of t-BuLi and much lower temperatures are required for a conventional macro batch reaction. Subsequent reactions with various electrophiles in the flow microreactor system gave the corresponding vinyl compounds in good......
Flow Synthesis of Symmetrical Di- and Trisulfides Using Phase-Transfer Catalysis
Journal of Flow Chemistry - Tập 3 - Trang 118-121 - 2013
Using mild conditions and short reaction times, symmetrical disulfides have been synthesized in flow chemistry using phase transfer catalysts to facilitate the substitution of organohalides with disodium disulfide. Also, the synthesis of symmetrical trisulfides was possible using this procedure with an additional equivalent of sulfur.
A device for continuous and flexible adjustment of liquid-liquid slug size in micro-channels
Journal of Flow Chemistry - Tập 10 - Trang 409-422 - 2020
In liquid-liquid segmented flow slug size determines the interfacial area as well as the intensity of Taylor vortices and is thus an important operational parameter, decisive for mass transfer performance of biphasic micro-reactors and -extractors. Resulting slug sizes conventionally depend on material properties, flow and geometric parameters of the mixing point of the liquids. To evade tedious m......
Photo-Induced Copper-Mediated Acrylate Polymerization in Continuous-Flow Reactors
Journal of Flow Chemistry - Tập 6 - Trang 260-267 - 2016
The synthetic scope of photo-induced copper-mediated polymerization (photoCMP) in continuous-flow reactors is further explored. A series of monomers, namely, methyl (MA), ethyl (EA), n-butyl (nBA), 2-hydroxyethyl (HEA), and di(ethylene glycol) ethyl ether (DEGA) acrylate are investigated, all showing high livingness (dispersity in the range of 1.1 and linear first order kinetics) in the polymeriza......
Design and scale-up of continuous di-nitration reaction using pinched tube flow reactor
Journal of Flow Chemistry - Tập 11 - Trang 611-624 - 2021
Scale-up of the di-nitration reaction for synthesis of selective herbicide pendimethalin using only nitric acid in continuous flow is presented in this work. This work showcases an approach for smooth scale-up for an herbicide for a production capacity of 50 kg/day using a pinched tube reactor. The approach begins with the batch experiments followed by flow synthesis using a 1/8-inchSS316 helical ......
Synthesis of a Key Intermediate towards the Preparation of Efavirenz Using n-Butyllithium
Journal of Flow Chemistry - Tập 7 - Trang 37-40 - 2017
A key reaction in one of the routes to efavirenz, an essential drug used in the treatment of acquired immunodeficiency syndrome (AIDS), is the ortho-lithiation reaction of N-Boc-4-chloroaniline. For the first time, we demonstrate that the reaction may be conducted using n-BuLi and show that the reaction may be performed in a flow reactor with a significantly higher yield (70%) compared to batch (2......
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Enantioselective catalytic Strecker reaction on cyclic (Z)-aldimines in flow: reaction optimization and sustainability aspects
Journal of Flow Chemistry - - Trang 1-14 - 2023
Catalytic enantioselective Strecker reactions on an achiral substrate using sub-stoichiometric amounts of a chiral catalyst represent an evolving key strategy for the effective synthesis of α-amino nitriles. We herein disclosed the set-up of a flow-based methodology for enantioselective Strecker, employing ethyl cyanoformate as a relatively safe cyanide source, a cinchona-based catalyst, and metha......
Highlights from the Flow Chemistry Literature 2015 (Part 4)
Journal of Flow Chemistry - Tập 6 - Trang 62-66 - 2016
In this Section of the journal, the literature on continuous flow synthesis (primarily organic synthesis and functional materials) from the period of October–December 2015 is presented. All the publications are listed ordered by journal name, with a Review article appearing at the end. In this quarter the number of papers on flow synthesis of nanomaterials is relatively higher than in the previous......
Telescoped continuous flow synthesis of phenyl acrylamide
Journal of Flow Chemistry - - 2020
Functional acrylamides are valuable intermediates for organic synthesis and building blocks in many industrial areas, like polymer synthesis, fine chemicals and pharmaceutics. The conventional batch reaction copes with some safety issues, due to the intrinsic reactivity and careful handling of the reagents. Moreover, the hazardous solvents used and the energy consumed have an enormous environmenta......
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