Diastereoselective [2+2] Photocycloaddition of a Chiral Cyclohexenone with Ethylene in a Continuous Flow Microcapillary Reactor

Journal of Flow Chemistry - Tập 2 - Trang 73-76 - 2012
Kimitada Terao1, Yasuhiro Nishiyama1, Hiroki Tanimoto1, Tsumoru Morimoto1, Michael Oelgemöller2, Kiyomi Kakiuchi1
1Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), Ikoma Nara, Japan
2School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia

Tóm tắt

The diastereoselective [2+2] photocycloaddition of ethylene to a chiral cyclohexenone was studied in a continuous flow microcapillary reactor. In all cases examined, the microcapillary reactor gave higher conversions and selectivity than the batch system, even after shorter irradiation times. These findings were explained by the superior temperature control, favorable light penetration, and generation of a gas-liquid slug flow with improved mass transfer in the microreactor.

Tài liệu tham khảo

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