Journal of Cerebral Blood Flow and Metabolism
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Attenuation of Stroke Size in Rats Using an Adenoviral Vector to Induce Overexpression of Interleukin-1 Receptor Antagonist in Brain Adenoviruses have been proposed as potential vectors for gene therapy in the central nervous system, but there are no reports of their use in the treatment of a brain disease. Because central administration of interleukin-1 receptor antagonist protein (IL-1ra) reduces ischemic brain damage, we determined whether a recombinant adenovirus vector carrying the human IL-1ra cDNA (Ad.RSV IL-1ra... ... hiện toàn bộ
Journal of Cerebral Blood Flow and Metabolism - Tập 15 Số 4 - Trang 547-551 - 1995
Nimodipine Cải Thiện Lưu Lượng Máu Não và Khả Năng Phục Hồi Thần Kinh Sau Khi Bị Thiếu Máu Não Hoàn Toàn ở Chó Dịch bởi AI Mười phút thiếu máu hoàn toàn đã được tạo ra trên 11 con chó bằng cách thắt tạm thời động mạch chủ. Ngay trước khi xảy ra thiếu máu, những con chó này đã nhận được nimodipine, một loại thuốc chẹn kênh canxi mới, với liều 10 μg kg−1 , tiêm tĩnh mạch, sau đó được truyền với liều 1 μg kg−1 phút−1 trong 2 giờ. Lưu lượng máu não và ... ... hiện toàn bộ
Journal of Cerebral Blood Flow and Metabolism - Tập 3 Số 1 - Trang 38-43 - 1983
Treatment with an AMPA Antagonist 12 Hours following Severe Normothermic Forebrain Ischemia Prevents CA1 Neuronal Injury The neuroprotective effects of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo( f)quinoxaline (NBQX), GYKI 52466, and MK-801 were tested following severe forebrain ischemia. Wistar rats were subjected to 10 min of normothermic ischemia and reperfused for 7 days. Necrotic hippocampal CA1 neurons were counted and expressed as a percentage (mean ± SD). In Experiment 1, saline-tre... ... hiện toàn bộ
Journal of Cerebral Blood Flow and Metabolism - Tập 13 Số 6 - Trang 933-939 - 1993
Reactive Astrocytosis from Excitotoxic Injury in Hippocampal Organ Culture Parallels that Seen in Vivo Reactive astrocytes influence not only the severity of brain injury, but also the capacity of brain to reshape itself with learning. Mechanisms responsible for astrogliosis remain unknown but might be best studied in vitro, where improved access and visualization permit application of modern molecular and cellular techniques. We have begun to explore whether gliosis might be studied in hi... ... hiện toàn bộ
Journal of Cerebral Blood Flow and Metabolism - Tập 17 Số 1 - Trang 26-43 - 1997
Magnetic Resonance Imaging of Regional Hemodynamic and Cerebrovascular Recovery after Lateral Fluid-Percussion Brain Injury in Rats Hemodynamic and cerebrovascular factors are crucially involved in secondary damage after traumatic brain injury (TBI). With magnetic resonance imaging, this study aimed to quantify regional cerebral blood flow (CBF) by arterial spin labeling and cerebral blood volume by using an intravascular contrast agent, during 14 days after lateral fluid-percussion injury (LFPI) in rats. Immunohistoc... ... hiện toàn bộ
Journal of Cerebral Blood Flow and Metabolism - Tập 31 Số 1 - Trang 166-177 - 2011
Up-regulation of Wnt/β-catenin expression is accompanied with vascular repair after traumatic brain injury Recent data suggest that repairing the cerebral vasculature after traumatic brain injury (TBI) may help to improve functional recovery. The Wnt/β-catenin signaling pathway promotes blood vessel formation during vascular development, but its role in vascular repair after TBI remains elusive. In this study, we examined how the cerebral vasculature responds to TBI and the role of Wnt/β-caten... ... hiện toàn bộ
Journal of Cerebral Blood Flow and Metabolism - Tập 38 Số 2 - Trang 274-289 - 2018
Effects of voluntary exercise on structure and function of cortical microvasculature Aerobic activity has been shown highly beneficial to brain health, yet much uncertainty still surrounds the effects of exercise on the functioning of cerebral microvasculature. This study used two-photon fluorescence microscopy to examine cerebral hemodynamic alterations as well as accompanying geometric changes in the cortical microvascular network following five weeks of voluntary exerc... ... hiện toàn bộ
Journal of Cerebral Blood Flow and Metabolism - Tập 37 Số 3 - Trang 1046-1059 - 2017
Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury Cortical spreading depression (CSD) and depolarization waves are associated with dramatic failure of brain ion homeostasis, efflux of excitatory amino acids from nerve cells, increased energy metabolism and changes in cerebral blood flow (CBF). There is strong clinical and experimental evidence to suggest that CSD is involved in the mechanism of migraine, stroke, subarachnoid hemorrhage a... ... hiện toàn bộ
Journal of Cerebral Blood Flow and Metabolism - Tập 31 Số 1 - Trang 17-35 - 2011
Cerebral Metabolic Relationships for Selected Brain Regions in Healthy Adults The local cerebral metabolic rate for glucose was determined in 26 regions of the brain in 31 healthy subjects who underwent resting fluorodeoxyglucose positron emission tomography. Intercorrelations among the 26 regional measures were accepted as reliable at p < 0.01 (r > 0.45), uncorrected for the number of measures. From the matrix two apparently separate functional metabolic sys... ... hiện toàn bộ
Journal of Cerebral Blood Flow and Metabolism - Tập 4 Số 1 - Trang 1-7 - 1984
Cerebral Metabolic Relationships for Selected Brain Regions in Alzheimer's, Huntington's, and Parkinson's Diseases Local CMRGlc values were determined for 13 regions in each hemisphere from tomographs of patients with Alzheimer's, Huntington's, and Parkinson's diseases who were studied using [18 F]fluorodeoxyglucose with positron emission computed tomography. Intercorrelations among the 26 regional measures were calculated for each disease state and for normal controls, and were ac... ... hiện toàn bộ
Journal of Cerebral Blood Flow and Metabolism - Tập 4 Số 4 - Trang 500-506 - 1984
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