Journal of Cell Communication and Signaling
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
GAB2 và GAB3 được biểu hiện theo cách phụ thuộc vào giai đoạn, độ ác tính và kiểu mô và có liên quan đến thời gian sống không tiến triển ngắn hơn trong ung thư buồng trứng Dịch bởi AI
Journal of Cell Communication and Signaling - Tập 15 - Trang 57-70 - 2020
Ung thư buồng trứng là loại ung thư phụ khoa nguy hiểm nhất và các cơ chế phân tử của sự tiến triển và di căn của nó chưa được hiểu rõ hoàn toàn. Một số thành viên của gia đình protein GAB (liên kết với GRB2) đã được báo cáo là có liên quan đến sự phát triển và di căn của tế bào ung thư trong nhiều loại ung thư khác nhau. Trong nghiên cứu này, chúng tôi đã phân tích sự biểu hiện của các protein GA...... hiện toàn bộ
#ung thư buồng trứng #GAB2 #GAB3 #di căn #sự sống không tiến triển
K562 chronic myeloid leukemia cells modify osteogenic differentiation and gene expression of bone marrow stromal cells
Journal of Cell Communication and Signaling - Tập 12 - Trang 441-450 - 2017
Bone marrow (BM) microenvironment plays an important role in normal and malignant hematopoiesis. As a consequence of interaction with the leukemic cells, the stromal cells of the bone marrow become deregulated in their normal function and gene expression. In our study, we found that mesenchymal stem cells (MSC) from BM of chronic myeloid leukemia (CML) patients have defective osteogenic differenti...... hiện toàn bộ
Analysis of the MMP-dependent and independent functions of tissue inhibitor of metalloproteinase-2 on the invasiveness of breast cancer cells
Journal of Cell Communication and Signaling - Tập 6 - Trang 87-95 - 2012
Matrix metalloproteinases (MMPs) are secreted endopeptidases that play an essential role in remodeling the extracellular matrix (ECM). MMPs are primarily active during development, when the majority of ECM remodeling events occurs. In adults, elevated MMP activity has been observed in many pathological conditions such as cancer and osteoarthritis. The proteolytic activity of MMPs is controlled by ...... hiện toàn bộ
Autophagy enhancement is rendered ineffective in presence of α-synuclein in melanoma cells
Journal of Cell Communication and Signaling - Tập 11 - Trang 381-394 - 2017
Increased cellular concentration of α-synuclein (α-syn) predisposes it to misfolding and aggregation that in turn impair the degradation pathways. This poses a limitation to the use of overexpression models for studies on α-syn clearance by autophagy, which is widely investigated for its therapeutic potential. This limitation can be overcome with the use of endogenous models. In this study, SK-MEL...... hiện toàn bộ
The apoptotic inducible effects of salicylic acid on hepatoma cell line: relationship with nitric oxide signaling
Journal of Cell Communication and Signaling - Tập 11 - Trang 245-253 - 2017
Clinical and experimental data suggest that salicylic acid (SA) is tumor preventive and NO has a multitude of effects on tumor biology. Therefore, firstly, the aim of our study is to explore the important role of SA in apoptotic induction of liver cancer cells. Secondly, we investigate whether SA mediates the anti-tumor effects by NO signaling pathway. The liver cancer cell line was treated with d...... hiện toàn bộ
Humanin inhibits apoptosis in pituitary tumor cells through several signaling pathways including NF-κB activation
Journal of Cell Communication and Signaling - Tập 11 - Trang 329-340 - 2017
Humanin (HN) and Rattin (HNr), its homologous in the rat, are peptides with cytoprotective action in several cell types such as neurons, lymphocytes and testicular germ cells. Previously, we have shown that HNr is expressed in pituitary cells and that HN inhibited the apoptotic effect of TNF-α in both normal and tumor pituitary cells. The aim of the present study was to identify signaling pathways...... hiện toàn bộ
CCN2 expression and localization in melanoma cells
Journal of Cell Communication and Signaling - Tập 5 - Trang 219-226 - 2011
The matricellular protein connective tissue growth factor (CTGF, CCN2) is overexpressed in several forms of cancer and may represent a novel target in anti-cancer therapy. However, whether CCN2 is expressed in melanoma cells is unknown. The highly metastatic murine melanoma cell line B16(F10) was used for our studies. Real time polymerase chain reaction analysis was used to detect mRNA expression ...... hiện toàn bộ
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells
Journal of Cell Communication and Signaling - Tập 17 Số 4 - Trang 1371-1388 - 2023
Correction to: DNA damage response and repair pathway modulation by non-histone protein methylation: implications in neurodegeneration
Journal of Cell Communication and Signaling - Tập 15 - Trang 151-151 - 2020
The original version of this article unfortunately requires correction where the name of a methyltransferase was represented wrongly.
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