Journal of Cell Communication and Signaling

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METTL3–METTL14 complex induces necroptosis and inflammation of vascular smooth muscle cells via promoting N6 methyladenosine mRNA methylation of receptor-interacting protein 3 in abdominal aortic aneurysms
Journal of Cell Communication and Signaling - Tập 17 - Trang 897-914 - 2023
Kun Li, Dongbin Zhang, Shuiting Zhai, Huilin Wu, Hongzhi Liu
Abdominal aortic aneurysms (AAA) have the highest incidence and rupture rate of all aortic aneurysms. The N6 methyladenosine (m6A) modification is closely associated with angiotensin (Ang II)-induced aortic diseases. This study aimed to identify whether the m6A writer METTL3/METTL4 regulates rip3 mRNA expression in AAA. To induce the mouse AAA model, apolipoprotein E-deficient (ApoE-/-) mice were ...... hiện toàn bộ
Cellular senescence and autophagy of myoepithelial cells are involved in the progression of in situ areas of carcinoma ex-pleomorphic adenoma to invasive carcinoma. An in vitro model
Journal of Cell Communication and Signaling - - 2015
Carolina Amália Barcellos Silva, Elizabeth Ferreira Martinez, Ana Paula Dias Demasi, Albina Altemani, Jeruza P. Bossonaro, Ney Soares de Araújo, Vera Cavalcanti de Araújo
Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes
Journal of Cell Communication and Signaling - - 2023
Gary J. Fisher, Bo Wang, Yaqiong Cui, Ming Shi, Yi Zhao, Taihao Quan, John J. Voorhees
An interesting perspective on a well-studied pathway: does type III TGF-Β receptor have therapeutic potential?
Journal of Cell Communication and Signaling - Tập 9 - Trang 103-103 - 2015
Philip C. Trackman
The type III TGF-β receptor has potential therapeutic and prognostic potential in breast cancer.
Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer
Journal of Cell Communication and Signaling - Tập 17 - Trang 591-608 - 2022
Depanwita Saha, Debarpan Mitra, Neyaz Alam, Sagar Sen, Saunak Mitra Mustafi, Pradip K. Majumder, Biswanath Majumder, Nabendu Murmu
Vasculogenic mimicry (VM), defined as an endothelial cell independent alternative mechanism of blood and nutrient supply by dysregulated tumor cells, is associated with poor prognosis in oral squamous cell carcinoma (OSCC). Here we aim to investigate the underlying molecular mechanism of the synergistic effect of phytochemical Lupeol and standard microtubule inhibitor Paclitaxel in reversing the h...... hiện toàn bộ
Grape seed proanthocyanidins and metformin act by different mechanisms to promote insulin signaling in rats fed high calorie diet
Journal of Cell Communication and Signaling - - 2014
Baskaran Yogalakshmi, Saravanan Bhuvaneswari, S. Sreeja, Carani Venkatraman Anuradha
AbstractKey pathways like insulin signaling, AMP activated kinase (AMPK) activation and inflammatory signaling are involved in the complex pathological network of hepatic insulin resistance. Our aim is to investigate whether grape seed proanthocyanidins (GSP) and metformin (MET) target any of these pathways in insulin resistant rat liver. Albino Wistar rats were re...... hiện toàn bộ
The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence
Journal of Cell Communication and Signaling - Tập 17 - Trang 409-422 - 2022
Seyyede Fatemeh Hashemi, Hossein Khorramdelazad
Chemokines are immune system mediators that mediate various activities and play a role in the pathogenesis of several cancers. Among these chemokines, C-X-C motif chemokine 17 (CXCL-17) is a relatively novel molecule produced along the airway epithelium in physiological and pathological conditions, and evidence shows that it plays a homeostatic role in most cases. CXCL17 has a protective role in s...... hiện toàn bộ
Encapsulation of eukaryotic cells in alginate microparticles: cell signaling by TNF-alpha through capsular structure of cystic fibrosis cells
Journal of Cell Communication and Signaling - Tập 5 - Trang 157-165 - 2010
Stefania Mazzitelli, Monica Borgatti, Giulia Breveglieri, Roberto Gambari, Claudio Nastruzzi
Entrapment of mammalian cells in natural or synthetic biomaterials represents an important tool for both basic and applied research in tissue engineering. For instance, the encapsulation procedures allow to physically isolate cells from the surrounding environment, after their transplantation maintaining the normal cellular physiology. The first part of the current paper describes different microe...... hiện toàn bộ
CCN5 in alveolar epithelial proliferation and differentiation during neonatal lung oxygen injury
Journal of Cell Communication and Signaling - Tập 12 - Trang 217-229 - 2018
Najla Fiaturi, Joshua W. Russo, Heber C. Nielsen, John J. Castellot
Lung immaturity is the major cause of morbidity and mortality in premature infants, especially those born <28 weeks of gestation. These infants are at high risk of developing respiratory distress syndrome (RDS), a lung disease caused by insufficient surfactant production and immaturity of saccular/alveolar type II epithelial cells in the lung. RDS treatment includes oxygen and respiratory support ...... hiện toàn bộ
Sequence features, structure, ligand interaction, and diseases in small leucine rich repeat proteoglycans
Journal of Cell Communication and Signaling - Tập 15 - Trang 519-531 - 2021
Norio Matsushima, Hiroki Miyashita, Robert H. Kretsinger
Small leucine rich repeat proteoglycans (SLRPs) are a group of active components of the extracellular matrix in all tissues. SLRPs bind to collagens and regulate collagen fibril growth and fibril organization. SLRPs also interact with various cytokines and extracellular compounds, which lead to various biological functions such cell adhesion and signaling, proliferation, and differentiation. Mutat...... hiện toàn bộ
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