AbstractIntegrity of the extracellular matrix (ECM) is essential for maintaining
the normal structure and function of connective tissues. ECM is secreted locally
by cells and organized into a complex meshwork providing physical support to
cells, tissues, and organs. Initially thought to act only as a scaffold, the ECM
is now known to provide a myriad of signals to cells regulating all aspects of
t... hiện toàn bộ
AbstractIn recent months, four different systems have been reported in the
literature in which CCN2 transgenes were individually expressed in podocytes,
hepatocytes, cardiomyocytes or respiratory epithelial cells to achieve
overexpression in, respectively, the kidney, liver, heart, or lung. These
transgenic systems have provided valuable information about the contribution of
CCN2 to fibrosis in vi... hiện toàn bộ