Journal of Cardiovascular Pharmacology and Therapeutics
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Statins Reduce Appropriate Cardioverter-Defibrillator Shocks and Mortality in Patients With Heart Failure and Combined Cardiac Resynchronization and Implantable Cardioverter-Defibrillator Therapy
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 14 Số 3 - Trang 176-179 - 2009
Of 209 patients with heart failure treated with combined cardiac
resynchronization therapy and implantable cardioverter-defibrillator therapy,
appropriate cardioverter-defibrillator shocks occurred at 34-month follow-up in
22 of 121 patients (18%) on statins and in 30 of 88 patients (34%) not on
statins (P = .009). Deaths occurred in 3 of 121 patients (2%) on statins and in
9 of 88 patients (10%) ...
Ticagrelor Inhibits Adenosine Uptake In Vitro and Enhances Adenosine-Mediated Hyperemia Responses in a Canine Model
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 17 Số 2 - Trang 164-172 - 2012
Aims: A routine secondary pharmacology screen indicated that reversibly binding
oral P2Y12 receptor antagonist ticagrelor could inhibit adenosine uptake in
human erythrocytes, suggesting that ticagrelor may potentiate adenosine-mediated
responses in vivo. The aim of this study was to further characterize the
adenosine uptake inhibition in vitro and study possible physiological
consequences of aden...
Efficacy of Atorvastatin Compared With Simvastatin in Patients With Hypercholesterolemia
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 5 Số 1 - Trang 27-32 - 2000
Background: Atorvastatin, a new enantiomerically pure synthetic statin, has
shown a marked low-density lipoprotein (LDL) cholesterol reduction at doses
ranging from 10 to 80 mg/d. This trial was designed to compare the efficacy of
atorvastatin 10 mg with simvastatin 10 mg and 20 mg, the latter dose being
commonly used in some countries. Methods and Results: A parallel group,
randomized, PROBE, mul...
The Protective Effect of Bergamot Oil Extract on Lecitine-like OxyLDL Receptor-1 Expression in Balloon Injury-related Neointima Formation
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 13 Số 2 - Trang 120-129 - 2008
Lectin-like oxyLDL receptor-1 (LOX-1) has recently been suggested to be involved
in smooth muscle cell (SMC) proliferation and neointima formation in injured
blood vessels. This study evaluates the effect of the nonvolatile fraction
(NVF), the antioxidant component of bergamot essential oil (BEO), on LOX-1
expression and free radical generation in a model of rat angioplasty. Common
carotid arterie...
Effects of Pioglitazone on High-Fat-Diet–Induced Ventricular Remodeling and Dysfunction in Rats
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 17 Số 2 - Trang 223-228 - 2012
Objective: To investigate the effect of pioglitazone on high-fat
(HF)-diet–induced left ventricular (LV) hypertrophy and dysfunction in rats.
Methods: A total of 36 male Sprague-Dawley rats were randomly divided into 3
groups, namely, control, HF diet, and pioglitazone treatment group. High-fat
diet group (HF group) animals were treated with HF diet for 30 weeks, whereas
pioglitazone group was tre...
Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 17 Số 3 - Trang 315-323 - 2012
High-density lipoprotein (HDL)-targeting therapies, including reconstituted HDL
(rHDL), are attractive agents for treating dyslipidemia and atherosclerosis, as
they may increase HDL levels and enhance therapeutic activities associated with
HDL, including reverse cholesterol transport (RCT). Using CSL-111, a rHDL
consisting of native human apolipoprotein AI (hApoAI) and phospholipids, we
characteri...
Reverse D4F, an Apolipoprotein-AI Mimetic Peptide, Inhibits Atherosclerosis in ApoE-null Mice
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 17 Số 3 - Trang 334-343 - 2012
Objective: Synthetic class A amphipathic helical peptide analogs of
apolipoprotein-AI (apoAI; with varied phenylalanine residues) are emerging
therapeutic approaches under investigation for atherosclerosis. Utilizing
retroinverso sequencing, we designed reverse-D4F (Rev-D4F) peptide with 18
d-amino acids containing 4 phenylalanine residues and reverse order that allows
the side chain residues to b...
Prospects for the Primary Prevention of Myocardial Infarction and Stroke
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 24 Số 3 - Trang 207-214 - 2019
Cardiovascular disease (CVD), principally myocardial infarction (MI) and stroke,
is the leading clinical and public health problem in the United States and is
rapidly becoming so worldwide. Their primary prevention is promising, in theory,
but difficult to achieve in practice. The principal modalities that have
demonstrated efficacy include therapeutic lifestyle changes (TLCs) and
adjunctive drug ...
Metabolic Syndrome
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 22 Số 4 - Trang 365-367 - 2017
The United States is experiencing its greatest life expectancy ever.
Nonetheless, the general health of the US population is far from at an all-time
high. An important contributor to the pandemic of cardiovascular disease is that
overweight and obesity are also the major determinants of metabolic syndrome, an
all too common and all too serious clinical and public health challenge.
Clinicians have ...
Antiarrhythmic Action ofβ-Blockers: Potential Mechanisms
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 10 Số 4_suppl - Trang S15-S22 - 2005
Sympathetic nervous system overactivity has been linked to ventricular
tachyarrhythmias and sudden death. It has been hypothesized that the extent and
nature of the arrhythmogenic effect of sympathetic stimulation depends on the
underlying myocardial substrate, the mechanism of the arrhythmia, and the
integrated effects of sympathetic stimulation in the particular individual
circumstance. Multiple...
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