Journal of Cardiovascular Pharmacology and Therapeutics

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Statins Reduce Appropriate Cardioverter-Defibrillator Shocks and Mortality in Patients With Heart Failure and Combined Cardiac Resynchronization and Implantable Cardioverter-Defibrillator Therapy
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 14 Số 3 - Trang 176-179 - 2009
Harit Desai, Wilbert S. Aronow, Fausan S. Tsai, Chul Ahn, Hoang M. Lai, Harshad Amin, Kaushang Gandhi, William H. Frishman, Martin Cohen, Carmine Sorbera
Of 209 patients with heart failure treated with combined cardiac resynchronization therapy and implantable cardioverter-defibrillator therapy, appropriate cardioverter-defibrillator shocks occurred at 34-month follow-up in 22 of 121 patients (18%) on statins and in 30 of 88 patients (34%) not on statins (P = .009). Deaths occurred in 3 of 121 patients (2%) on statins and in 9 of 88 patien...... hiện toàn bộ
Ticagrelor Inhibits Adenosine Uptake In Vitro and Enhances Adenosine-Mediated Hyperemia Responses in a Canine Model
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 17 Số 2 - Trang 164-172 - 2012
J.J.J. van Giezen, James E. Sidaway, Philip Glaves, Ian P. Kirk, Jan‐Arne Björkman
Aims: A routine secondary pharmacology screen indicated that reversibly binding oral P2Y12 receptor antagonist ticagrelor could inhibit adenosine uptake in human erythrocytes, suggesting that ticagrelor may potentiate adenosine-mediated responses in vivo. The aim of this study was to further characterize the adenosine uptake inhibition in vitro and study possible phys...... hiện toàn bộ
Efficacy of Atorvastatin Compared With Simvastatin in Patients With Hypercholesterolemia
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 5 Số 1 - Trang 27-32 - 2000
Michel Farnier, Jean-Jacques Portal, P Maigret
Background: Atorvastatin, a new enantiomerically pure synthetic statin, has shown a marked low-density lipoprotein (LDL) cholesterol reduction at doses ranging from 10 to 80 mg/d. This trial was designed to compare the efficacy of atorvastatin 10 mg with simvastatin 10 mg and 20 mg, the latter dose being commonly used in some countries. Methods and Results: A parallel gr...... hiện toàn bộ
The Protective Effect of Bergamot Oil Extract on Lecitine-like OxyLDL Receptor-1 Expression in Balloon Injury-related Neointima Formation
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 13 Số 2 - Trang 120-129 - 2008
Vincenzo Mollace, Salvatore Ragusa, Iolanda Sacco, Carolina Muscoli, Francesca Sculco, Valeria Visalli, Ernesto Palma, Saverio Muscoli, Luigi Mondello, Paola Dugo, Domenicantonio Rotiroti, Francesco Romeo
Lectin-like oxyLDL receptor-1 (LOX-1) has recently been suggested to be involved in smooth muscle cell (SMC) proliferation and neointima formation in injured blood vessels. This study evaluates the effect of the nonvolatile fraction (NVF), the antioxidant component of bergamot essential oil (BEO), on LOX-1 expression and free radical generation in a model of rat angioplasty. Common caroti...... hiện toàn bộ
Effects of Pioglitazone on High-Fat-Diet–Induced Ventricular Remodeling and Dysfunction in Rats
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 17 Số 2 - Trang 223-228 - 2012
Yaqiang Tian, Shou-she LI, Xudong Su, Guangzhen Zhang, Jiajun Zhao, Guangwei Li, Lexin Wang
Objective: To investigate the effect of pioglitazone on high-fat (HF)-diet–induced left ventricular (LV) hypertrophy and dysfunction in rats. Methods: A total of 36 male Sprague-Dawley rats were randomly divided into 3 groups, namely, control, HF diet, and pioglitazone treatment group. High-fat diet group (HF group) animals were treated with HF diet for 30 weeks, whereas pioglitazone grou...... hiện toàn bộ
Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 17 Số 3 - Trang 315-323 - 2012
Zhu Chen, Edward A. O’Neill, Roger Meurer, Karen Gagen, Silvi Luell, Shengping Wang, Marina Ichetovkin, Betsy Frantz-Wattley, Suzanne S. Eveland, Alison M. Strack, Timothy S. Fisher, Douglas G. Johns, Carl P. Sparrow, Samuel D. Wright, Brian K. Hubbard, Ester Carballo‐Jane
High-density lipoprotein (HDL)-targeting therapies, including reconstituted HDL (rHDL), are attractive agents for treating dyslipidemia and atherosclerosis, as they may increase HDL levels and enhance therapeutic activities associated with HDL, including reverse cholesterol transport (RCT). Using CSL-111, a rHDL consisting of native human apolipoprotein AI (hApoAI) and phospholipids, we c...... hiện toàn bộ
Reverse D4F, an Apolipoprotein-AI Mimetic Peptide, Inhibits Atherosclerosis in ApoE-null Mice
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 17 Số 3 - Trang 334-343 - 2012
Shucun Qin, Vaijinath S. Kamanna, Jack H. Lai, Tianjiao Liu, Shobha H. Ganji, Linhua Zhang, William W. Bachovchin, Moti L. Kashyap
Objective: Synthetic class A amphipathic helical peptide analogs of apolipoprotein-AI (apoAI; with varied phenylalanine residues) are emerging therapeutic approaches under investigation for atherosclerosis. Utilizing retroinverso sequencing, we designed reverse-D4F (Rev-D4F) peptide with 18 d-amino acids containing 4 phenylalanine residues and reverse ord...... hiện toàn bộ
Prospects for the Primary Prevention of Myocardial Infarction and Stroke
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 24 Số 3 - Trang 207-214 - 2019
Madison Caldwell, Lisa Martínez, Jennifer Foster, Dawn Harris Sherling, Charles H. Hennekens
Cardiovascular disease (CVD), principally myocardial infarction (MI) and stroke, is the leading clinical and public health problem in the United States and is rapidly becoming so worldwide. Their primary prevention is promising, in theory, but difficult to achieve in practice. The principal modalities that have demonstrated efficacy include therapeutic lifestyle changes (TLCs) and adjunct...... hiện toàn bộ
Metabolic Syndrome
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 22 Số 4 - Trang 365-367 - 2017
Dawn Harris Sherling, Parvathi Perumareddi, Charles H. Hennekens
The United States is experiencing its greatest life expectancy ever. Nonetheless, the general health of the US population is far from at an all-time high. An important contributor to the pandemic of cardiovascular disease is that overweight and obesity are also the major determinants of metabolic syndrome, an all too common and all too serious clinical and public health challenge. Clinici...... hiện toàn bộ
Antiarrhythmic Action ofβ-Blockers: Potential Mechanisms
Journal of Cardiovascular Pharmacology and Therapeutics - Tập 10 Số 4_suppl - Trang S15-S22 - 2005
Paul Dorian
Sympathetic nervous system overactivity has been linked to ventricular tachyarrhythmias and sudden death. It has been hypothesized that the extent and nature of the arrhythmogenic effect of sympathetic stimulation depends on the underlying myocardial substrate, the mechanism of the arrhythmia, and the integrated effects of sympathetic stimulation in the particular individual circumstance....... hiện toàn bộ
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