Journal of Biology
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Sắp xếp:
The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
Journal of Biology - Tập 1 - Trang 1-4 - 2002
The discovery of small molecules that act as agonists and antagonists of the
Hedgehog-Gli signaling pathway, which plays important roles in the embryo and
adult, opens a new avenue for the treatment of diseases caused by aberrant
suppression or activation of this complex pathway.
Conserved elements within open reading frames of mammalian Hox genes
Journal of Biology - Tập 8 - Trang 1-4 - 2009
A recent study in BMC Evolutionary Biology shows that many of the open reading
frames in mammalian Hox genes are more conserved than expected on the basis of
their protein sequence. The presence of highly conserved DNA elements is thus
not confined to the noncoding DNA in neighboring regions but clearly overlaps
with coding sequences. These findings support an emerging view that gene
regulatory an...
The future of artemisinins: natural, synthetic or recombinant?
Journal of Biology - Tập 7 - Trang 1-5 - 2008
Artemisinins are the most important anti-malarial drugs in use today, but are
more costly than previous anti-malarials and production and price tend to
fluctuate. Alternative ways of producing artemisinins are discussed here in the
light of a recent paper in BMC Biotechnology on improving the yield of the
precursor, artemisinic acid, in genetically engineered yeast.
Regulators of kinesin involved in polarized trafficking and axon outgrowth
Journal of Biology - Tập 5 - Trang 1-4 - 2006
Proteins such as UNC-76 that associate with kinesin motors are important in
directing neurite extension. A small Caenorhabditis elegans coiled-coil protein,
UNC-69, has now been shown to interact with UNC-76 and to be involved in axonal
(but not dendritic) transport and outgrowth, as well as synapse formation.
Mapping the protistan 'rare biosphere'
Journal of Biology - Tập 8 - Trang 1-3 - 2009
The use of cultivation-independent approaches to map microbial diversity,
including recent work published in BMC Biology, has now shown that protists,
like bacteria/archaea, are much more diverse than had been realized. Uncovering
eukaryotic diversity may now be limited not by access to samples or cost but
rather by the availability of full-length reference sequence data. See research
article http...
The absolute pitch mind continues to reveal itself
Journal of Biology - Tập 8 - Trang 1-4 - 2009
Absolute pitch has proved useful as an alternative perspective from which to
investigate various cognitive faculties. A new functional magnetic resonance
imaging study published recently in BMC Neuroscience adds new data to the
ongoing debate concerning the neural underpinnings of this unusual ability.
A balancing act between the X chromosome and the autosomes
Journal of Biology - Tập 5 Số 1 - Trang 1-3 - 2006
Dosage compensation equalizes gene dosage between males and females, but its
role in balancing expression between the X chromosome and the autosomes may be
far more important. Now, DNA microarrays have shown equality between the average
expression of X-linked genes and that of autosomal genes, in male and female
tissues of flies, worms and mice.
Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
Journal of Biology - Tập 6 - Trang 1-18 - 2007
Eukaryotic cells have evolved various response mechanisms to counteract the
deleterious consequences of oxidative stress. Among these processes, metabolic
alterations seem to play an important role. We recently discovered that yeast
cells with reduced activity of the key glycolytic enzyme triosephosphate
isomerase exhibit an increased resistance to the thiol-oxidizing reagent
diamide. Here we show...
At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation
Journal of Biology - - 2003
The tumor suppressor kinase LKB1 has been identified as a physiologic activator
of the key metabolic regulator 5'-AMP-activated protein kinase, establishing a
possible molecular link between the regulation of metabolism and cell
proliferation.
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