Journal of Biology
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The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
Journal of Biology - Tập 1 - Trang 1-4 - 2002
The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway, which plays important roles in the embryo and adult, opens a new avenue for the treatment of diseases caused by aberrant suppression or activation of this complex pathway.
Connecting LKB1 and AMPK links metabolism with cancer
Journal of Biology - Tập 2 - Trang 1-4 - 2003
The tumor suppressor gene product LKB1 has been identified as the upstream activating kinase for the stress-responsive AMP-activated kinase, providing a link between regulators of cellular metabolism and cell proliferation in cancer.
Conserved elements within open reading frames of mammalian Hox genes
Journal of Biology - Tập 8 - Trang 1-4 - 2009
A recent study in BMC Evolutionary Biology shows that many of the open reading frames in mammalian Hox genes are more conserved than expected on the basis of their protein sequence. The presence of highly conserved DNA elements is thus not confined to the noncoding DNA in neighboring regions but clearly overlaps with coding sequences. These findings support an emerging view that gene regulatory an......
The future of artemisinins: natural, synthetic or recombinant?
Journal of Biology - Tập 7 - Trang 1-5 - 2008
Artemisinins are the most important anti-malarial drugs in use today, but are more costly than previous anti-malarials and production and price tend to fluctuate. Alternative ways of producing artemisinins are discussed here in the light of a recent paper in BMC Biotechnology on improving the yield of the precursor, artemisinic acid, in genetically engineered yeast.
Regulators of kinesin involved in polarized trafficking and axon outgrowth
Journal of Biology - Tập 5 - Trang 1-4 - 2006
Proteins such as UNC-76 that associate with kinesin motors are important in directing neurite extension. A small Caenorhabditis elegans coiled-coil protein, UNC-69, has now been shown to interact with UNC-76 and to be involved in axonal (but not dendritic) transport and outgrowth, as well as synapse formation.
Mapping the protistan 'rare biosphere'
Journal of Biology - Tập 8 - Trang 1-3 - 2009
The use of cultivation-independent approaches to map microbial diversity, including recent work published in BMC Biology, has now shown that protists, like bacteria/archaea, are much more diverse than had been realized. Uncovering eukaryotic diversity may now be limited not by access to samples or cost but rather by the availability of full-length reference sequence data. See research article
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The absolute pitch mind continues to reveal itself
Journal of Biology - Tập 8 - Trang 1-4 - 2009
Absolute pitch has proved useful as an alternative perspective from which to investigate various cognitive faculties. A new functional magnetic resonance imaging study published recently in BMC Neuroscience adds new data to the ongoing debate concerning the neural underpinnings of this unusual ability.
A balancing act between the X chromosome and the autosomes
Journal of Biology - Tập 5 Số 1 - Trang 1-3 - 2006
Dosage compensation equalizes gene dosage between males and females, but its role in balancing expression between the X chromosome and the autosomes may be far more important. Now, DNA microarrays have shown equality between the average expression of X-linked genes and that of autosomal genes, in male and female tissues of flies, worms and mice.
Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress
Journal of Biology - Tập 6 - Trang 1-18 - 2007
Eukaryotic cells have evolved various response mechanisms to counteract the deleterious consequences of oxidative stress. Among these processes, metabolic alterations seem to play an important role. We recently discovered that yeast cells with reduced activity of the key glycolytic enzyme triosephosphate isomerase exhibit an increased resistance to the thiol-oxidizing reagent diamide. Here we show......
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