Journal of Applied Toxicology

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Protection against thallium hepatotoxicity by Silymarin
Journal of Applied Toxicology - Tập 8 Số 5 - Trang 351-354 - 1988
Marisabel Mourelle, Liliana Favari, José Luis Amezcua
AbstractThe effect of silymarin (100 mg/kg i.p.) on the biochemical indicators of liver damage induced by thallium (10 mg/kg p.o.) was studied in rats. The production of malondialdehyde and the content of reduced glutathione in the liver were measured as indicators of lipid peroxidation. Thallium intoxication increased the serum activities of glutamic pyruvic trans...... hiện toàn bộ
Aflatoxin biomarkers in hair may facilitate long‐term exposure studies
Journal of Applied Toxicology - Tập 37 Số 4 - Trang 395-399 - 2017
Innocent Mupunga, Christo D. Izaaks, Leshweni Jeremia Shai, David R. Katerere
AbstractAflatoxins are highly toxic fungal metabolites produced by some members of the Aspergillus species. They are low molecular weight lipophilic compounds that are easily absorbed from the gastrointestinal tract. They contaminate most staple foods, including maize, peanuts, peanut butter and sorghum mainly in the tropics where hot and...... hiện toàn bộ
Calibration and validation of a physiologically based model for soman intoxication in the rat, marmoset, guinea pig and pig
Journal of Applied Toxicology - Tập 32 Số 9 - Trang 673-686 - 2012
Kaizhen Chen, Kok‐Yong Seng
ABSTRACTA physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model has been developed for low, medium and high levels of soman intoxication in the rat, marmoset, guinea pig and pig. The primary objective of this model was to describe the pharmacokinetics of soman after intravenous, intramuscular and subcutaneous administration in the rat, marmoset,...... hiện toàn bộ
Comparison of the effects of erdosteine and N-acetylcysteine on apoptosis regulation in endotoxin-induced acute lung injury
Journal of Applied Toxicology - Tập 26 Số 4 - Trang 301-308 - 2006
Rezan Demiralay, Nesrin Gürsan, Gülay Özbilim, Gülgün Erdoğan, Elif Demirci
A simple approach to validation of directed‐flow nose‐only inhalation chambers
Journal of Applied Toxicology - Tập 27 Số 2 - Trang 160-167 - 2007
Jürgen Pauluhn, Achim Thiel
AbstractDirected‐flow nose‐only exposure systems are designed and operated so that the genuine test atmosphere is dynamically delivered to each exposure port and exhaled air from exposed animals is immediately exhausted without the possibility of other animals rebreathing this atmosphere. This technique is particularly useful for preventing uncontrolled changes of ...... hiện toàn bộ
Studies on the toxic effects of microcystin‐LR on the zebrafish (Danio rerio) under different temperatures
Journal of Applied Toxicology - Tập 31 Số 6 - Trang 561-567 - 2011
Xuezhen Zhang, Wei Ji, Huan Zhang, Wei Zhang, Ping Xie
AbstractIt is well known that fish have stronger tolerance than mammals to microcystin (MC) exposure, and such a difference is attributed to their different core body temperatures. However, no in vivo study has been conducted to investigate the effects of temperature on MC‐induced toxicity in fish, a typical poikilotherm. Tolerance and de...... hiện toàn bộ
Developmental toxicity assay using high content screening of zebrafish embryos
Journal of Applied Toxicology - Tập 35 Số 3 - Trang 261-272 - 2015
Susan M. Lantz, Xiaoqing Guo, Elvis Cuevas, M Dumas, Glenn D. Newport, Syed F. Ali, Merle G. Paule, Jyotshna Kanungo
AbstractTypically, time‐consuming standard toxicological assays using the zebrafish (Danio rerio) embryo model evaluate mortality and teratogenicity after exposure during the first 2 days post‐fertilization. Here we describe an automated image‐based high content screening (HCS) assay to identify the teratogenic/embryotoxic potential of co...... hiện toàn bộ
Toxicogenomics: a pivotal piece in the puzzle of toxicological research
Journal of Applied Toxicology - Tập 27 Số 4 - Trang 302-309 - 2007
Elisavet Gatzidou, Athina Zira, Stamatios Theocharis
AbstractToxicogenomics, resulting from the merge of conventional toxicology with functional genomics, being the scientific field studying the complex interactions between the cellular genome, toxic agents in the environment, organ dysfunction and disease state. When an organism is exposed to a toxic agent the cells respond by altering the pattern of gene expression...... hiện toàn bộ
Facilitating the use of non-standardin vivostudies in health risk assessment of chemicals: a proposal to improve evaluation criteria and reporting
Journal of Applied Toxicology - Tập 34 Số 6 - Trang 607-617 - 2014
Anna Beronius, Linda Molander, Christina Rudén, Annika Hanberg
Adrenocortical hypertrophy: establishing cause and toxicological significance
Journal of Applied Toxicology - Tập 30 Số 7 - Trang 617-626 - 2010
Philip W. Harvey, Catherine G. Sutcliffe
AbstractThe primary cause of adrenocortical hypertrophy is increased adrenocorticotrophic hormone (ACTH) stimulation. In toxicology studies, such a condition can arise as a result of the stress response, but it may also occur due to deficient glucocorticoid feedback regulation of ACTH due to toxicity to the adrenal cortex. This latter condition is defined as adreno...... hiện toàn bộ
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