Journal of Applied Toxicology

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Mitochondrial and liver oxidative stress alterations induced by N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine: relevance for hepatotoxicity
Journal of Applied Toxicology - Tập 33 Số 6 - Trang 434-443 - 2013
Maria Manuel Oliveira, José Teixeira, Cármen Nóbrega, Luís Félix, Vilma A. Sardão, Aura Colaço, Paula A. Oliveira, Francisco Peixoto
ABSTRACTThe most significant toxicological effect of nitrosamines like N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine (BBN) is their carcinogenic activity, which may result from exposure to a single large dose or from chronic exposure to relatively small doses. However, its effects on mitochondrial liver bioenergetics we...... hiện toàn bộ
Reduced mitochondrial membrane potential and metabolism correspond to acute chloroform toxicity ofin vitro hepatocytes
Journal of Applied Toxicology - Tập 25 Số 4 - Trang 310-317 - 2005
Sean M. Hartig, Serena Fries, R. Robert Balcarcel
Impact of glyphosate and glyphosate‐based herbicides on the freshwater environment
Journal of Applied Toxicology - Tập 34 Số 5 - Trang 458-479 - 2014
Robert D. Annett, Hamid R. Habibi, Alice Hontela
ABSTRACTGlyphosate [N‐(phosphonomethyl) glycine] is a broad spectrum, post emergent herbicide and is among the most widely used agricultural chemicals globally. Initially developed to control the growth of weed species in agriculture, this herbicide also plays an important role in both modern silviculture and domestic weed control. The cr...... hiện toàn bộ
Prevention by silymarin of membrane alterations in acute CCI4 liver damage
Journal of Applied Toxicology - Tập 10 Số 4 - Trang 275-279 - 1990
Pablo Muriel, Marisabel Mourelle
AbstractThe effect of silymarin on liver lipid peroxidation and membrane lipid alterations induced by an acute dose of CCI4 was studied. Four groups of animals were treated with CCI4, CCI4 + silymarin, silymarin and its vehicles. CCI4 was given orally (0.4 g 100 g−1... hiện toàn bộ
Protection against thallium hepatotoxicity by Silymarin
Journal of Applied Toxicology - Tập 8 Số 5 - Trang 351-354 - 1988
Marisabel Mourelle, Liliana Favari, José Luis Amezcua
AbstractThe effect of silymarin (100 mg/kg i.p.) on the biochemical indicators of liver damage induced by thallium (10 mg/kg p.o.) was studied in rats. The production of malondialdehyde and the content of reduced glutathione in the liver were measured as indicators of lipid peroxidation. Thallium intoxication increased the serum activities of glutamic pyruvic trans...... hiện toàn bộ
Review of the health effects of methylmercury
Journal of Applied Toxicology - Tập 5 Số 3 - Trang 113-133 - 1985
M. J. Inskip, J. K. Piotrowski
AbstractThe study critically reviews recent data relating to the health effects of methylmercury in man and the attendant dose‐response relationships. New data obtained from animal studies, including pre‐ and postnatal exposure, are also examined. The consumption of fish and fish produce represents the major source of methylmercury exposure in the general populatio...... hiện toàn bộ
Influence of the surface coating on the cytotoxicity, genotoxicity and uptake of gold nanoparticles in human HepG2 cells
Journal of Applied Toxicology - Tập 33 Số 10 - Trang 1111-1119 - 2013
Sónia Fraga, Helena Faria, Maria Elisa Soares, José Alberto Duarte, Leonor Soares, Eulália Pereira, Cristiana Pereira, João Paulo Teixeira, Maria de Lourdes Bastos, Helena Carmo
ABSTRACTThe toxicological profile of gold nanoparticles (AuNPs) remains controversial. Significant efforts to develop surface coatings to improve biocompatibility have been carried out. In vivo biodistribution studies have shown that the liver is a target for AuNPs accumulation. Therefore, we investigated the effects induced by ~20 nm sph...... hiện toàn bộ
Aflatoxin biomarkers in hair may facilitate long‐term exposure studies
Journal of Applied Toxicology - Tập 37 Số 4 - Trang 395-399 - 2017
Innocent Mupunga, Christo D. Izaaks, Leshweni Jeremia Shai, David R. Katerere
AbstractAflatoxins are highly toxic fungal metabolites produced by some members of the Aspergillus species. They are low molecular weight lipophilic compounds that are easily absorbed from the gastrointestinal tract. They contaminate most staple foods, including maize, peanuts, peanut butter and sorghum mainly in the tropics where hot and...... hiện toàn bộ
Physiologically based modeling of p‐tert‐octylphenol kinetics following intravenous, oral or subcutaneous exposure in male and female Sprague–Dawley rats
Journal of Applied Toxicology - Tập 30 Số 5 - Trang 437-449 - 2010
G. Hamelin, Sami Haddad, Kannan Krishnan, Robert Tardif
AbstractThe objective of this study was to develop a physiologically based pharmacokinetic (PBPK) model for p‐tert‐octylphenol (OP) for understanding the qualitative and quantitative determinants of its kinetics in Sprague–Dawley rats. Compartments of the PBPK model included the liver, richly perfused tissues, p...... hiện toàn bộ
Calibration and validation of a physiologically based model for soman intoxication in the rat, marmoset, guinea pig and pig
Journal of Applied Toxicology - Tập 32 Số 9 - Trang 673-686 - 2012
Kaizhen Chen, Kok‐Yong Seng
ABSTRACTA physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model has been developed for low, medium and high levels of soman intoxication in the rat, marmoset, guinea pig and pig. The primary objective of this model was to describe the pharmacokinetics of soman after intravenous, intramuscular and subcutaneous administration in the rat, marmoset,...... hiện toàn bộ
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