Protection against thallium hepatotoxicity by Silymarin

Journal of Applied Toxicology - Tập 8 Số 5 - Trang 351-354 - 1988
Marisabel Mourelle1, Liliana Favari1, José Luis Amezcua1
1Pharmacology and Toxicology Department, Centro de Investigatión y de Estudios Avanzades del I.P.N., Apdo. Postal 14–740, Mexico 07000, D.F., Mexico

Tóm tắt

AbstractThe effect of silymarin (100 mg/kg i.p.) on the biochemical indicators of liver damage induced by thallium (10 mg/kg p.o.) was studied in rats. The production of malondialdehyde and the content of reduced glutathione in the liver were measured as indicators of lipid peroxidation. Thallium intoxication increased the serum activities of glutamic pyruvic transaminase, gamma‐glutamyl transpeptidase, alkaline phosphatase and the liver concentration of triglycerides. Thallium decreased the activity of alkaline phosphatase and increased that of gamma‐glutamyl transpeptidase in the liver cell membrane. It also abolished the membrane activity of Na+/K+ ATPase. Lipid peroxidation was enhanced by thallium as malondialdehyde production was increased and the content of reduced glutathione was decreased in the liver. Silymarin completely prevented all these changes. It is suggested that thallium toxicity is due, at least in part, to the promotion of lipid peroxidation. The membrane stabilizing effect of silymarin observed in this and in other models of liver toxicity is due to some antioxidant property, possibly related to its ability to scavenge free oxygen radicals.

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Tài liệu tham khảo

10.3109/15563658008985073

10.1378/chest.85.2.236

10.1001/archneur.1972.00490110090009

10.3109/15563658108990328

10.1016/0041-008X(67)90104-4

10.1016/0005-2736(69)90022-4

10.1016/S0006-291X(76)80273-2

Luckey T. D., 1977, Metal Toxicity in Mammals, 101

10.1007/978-94-011-6618-8_2

Raven H. M., 1979, Die antihepatotoxische wirkung von silymarin bei experimentellen leberschädigungen der rate durch tetra chlorcohlens to ff, D‐Galaktosamin und Allylalkohol, Arzneim.‐Forsch., 21, 1194

10.1016/0006-2952(85)90421-6

10.1126/science.107.2775.254

10.1016/S0076-6879(78)52032-6

Beutler G., 1963, Improved method for the determination of blood glutathione, J. Lab. Clin. Med., 61, 882

Plaa L. G., 1982, Principles and Methods of Toxicology

10.1083/jcb.8.2.413

Berger L., 1963, Standard Method of Clinical Chemistry

10.1016/0014-5793(72)80075-9

10.1093/ajcp/28.1.56

10.1002/jat.2550050108

10.1002/9780470316474.ch10

Recknagel R. O., 1967, Carbon tetrachloride hepatotoxicity, Pharmacol. Rev., 19, 145

Coodley E. L., 1969, Enzyme diagnosis in hepatobiliary disease, Am. J. Gastroenterol., 52, 189

10.1016/0002-9343(59)90175-5

10.1007/BF02533425

10.1016/0024-3205(83)90787-7

10.1016/0024-3205(82)90743-3

10.1016/0005-2744(68)90254-4

10.1002/jat.2550050106

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Journal of Applied Toxicology

Tập 8 Số 5

351-354

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