Journal of Applied Physiology

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Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia
Journal of Applied Physiology - Tập 116 Số 7 - Trang 893-904 - 2014
Nayia Petousi, Quentin P. P. Croft, Gianpiero L. Cavalleri, Hung‐Yuan Cheng, Federico Formenti, Kōji Ishida, Daniel Lunn, Mark McCormack, Kevin V. Shianna, Nick P. Talbot, Peter J. Ratcliffe, Peter A. Robbins
Tibetan natives have lived on the Tibetan plateau (altitude ∼4,000 m) for at least 25,000 years, and as such they are adapted to life and reproduction in a hypoxic environment. Recent studies have identified two genetic loci, EGLN1 and EPAS1, that have undergone natural selection in Tibetans, and further demonstrated an association of EGLN1/ EPAS1 genotype with hemoglobin concentration. Both genes... hiện toàn bộ
Invited Review: Estrogens effects on the brain: multiple sites and molecular mechanisms
Journal of Applied Physiology - Tập 91 Số 6 - Trang 2785-2801 - 2001
Bruce S. McEwen
Besides their well-established actions on reproductive functions, estrogens exert a variety of actions on many regions of the nervous system that influence higher cognitive function, pain mechanisms, fine motor skills, mood, and susceptibility to seizures; they also appear to have neuroprotective actions in relation to stroke damage and Alzheimer's disease. Estrogen actions are now recognized to o... hiện toàn bộ
An analysis of aerobic capacity in a large United States population
Journal of Applied Physiology - Tập 60 Số 2 - Trang 494-500 - 1986
James A. Vogel, John F. Patton, Robert P. Mello, W. Lee Daniels
This study presents a description of aerobic capacity in a large US population comprised of 1,514 men and 375 women. Such influencing factors as age, training state, occupation, and body composition were evaluated. The population consisted of new recruits entering the US Army from civilian life as well as soliders in a variety of assignments and physical training programs. Age ranged from 17 to 55... hiện toàn bộ
Reduction in maximal oxygen uptake with age.
Journal of Applied Physiology - Tập 35 Số 5 - Trang 649-654 - 1973
Irma Åstrand, Per‐Olof Åstrand, I. Hallbäck, Åsa Kilbom
Longitudinal variations in maximal oxygen intake with age and activity.
Journal of Applied Physiology - Tập 33 Số 6 - Trang 805-807 - 1972
Michael M. Dehn, Robert A. Bruce
Shunt and ventilation-perfusion distribution during partial liquid ventilation in healthy piglets
Journal of Applied Physiology - Tập 82 Số 3 - Trang 933-942 - 1997
Elisabeth Mates, J. Hildebrandt, J. Craig Jackson, Peter Tarczy‐Hornoch, Michael P. Hlastala
Mates, Elisabeth A., Jacob Hildebrandt, J. Craig Jackson, Peter Tarczy-Hornoch, and Michael P. Hlastala. Shunt and ventilation-perfusion distribution during partial liquid ventilation in healthy piglets. J. Appl. Physiol.82(3): 933–942, 1997.—Replacing gas in the lung with perfluorocarbon fluids (PFC) and periodically ventilating with a gas [partial liquid ventilation (PLV)] has been shown to impr... hiện toàn bộ
A method for perfusion of cerebral ventricles of the conscious monkey.
Journal of Applied Physiology - Tập 30 Số 4 - Trang 589-592 - 1971
R D Myers, Tony L. Yaksh, Geoffrey Hall, W. L. Veale
Continuous Recording of Blood Oxygen Tensions by Polarography
Journal of Applied Physiology - Tập 6 Số 3 - Trang 189-193 - 1953
Leland C. Clark, Richard M. Wolf, Donald L. Granger, Zena Taylor
Ozone-induced airway hyperresponsiveness and loss of neuronal M2 muscarinic receptor function
Journal of Applied Physiology - Tập 76 Số 3 - Trang 1088-1097 - 1994
A. H. Schultheis, David Bassett, A.D. Fryer
The effect of acute ozone exposure on the function of efferent parasympathetic nerves, M3 muscarinic receptors on airway smooth muscle, and inhibitory M2 muscarinic receptors on the parasympathetic nerves was studied. Immediately after exposure to 2.0 ppm ozone for 4 h, guinea pigs became hyperresponsive to electrical stimulation of the vagus nerves. The normal airway response to intravenous choli... hiện toàn bộ
Total respiratory tract deposition of fine micrometer-sized particles in healthy adults: empirical equations for sex and breathing pattern
Journal of Applied Physiology - Tập 101 Số 2 - Trang 401-412 - 2006
Chong S. Kim, Shu-Chieh Hu
Accurate dose estimation under various inhalation conditions is important for assessing both the potential health effects of pollutant particles and the therapeutic efficacy of medicinal aerosols. We measured total deposition fraction (TDF) of monodisperse micrometer-sized particles [particle diameter (Dp) = 1, 3, and 5 μm in diameter] in healthy adults (8 men and 7 women) in a wide range of breat... hiện toàn bộ
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