Journal of Applied Physiology

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Ozone-induced airway hyperresponsiveness and loss of neuronal M2 muscarinic receptor function
Journal of Applied Physiology - Tập 76 Số 3 - Trang 1088-1097 - 1994
A. H. Schultheis, David Bassett, A.D. Fryer
The effect of acute ozone exposure on the function of efferent parasympathetic nerves, M3 muscarinic receptors on airway smooth muscle, and inhibitory M2 muscarinic receptors on the parasympathetic nerves was studied. Immediately after exposure to 2.0 ppm ozone for 4 h, guinea pigs became hyperresponsive to electrical stimulation of the vagus nerves. The normal airway response to intraven...... hiện toàn bộ
Total respiratory tract deposition of fine micrometer-sized particles in healthy adults: empirical equations for sex and breathing pattern
Journal of Applied Physiology - Tập 101 Số 2 - Trang 401-412 - 2006
Chong S. Kim, Shu-Chieh Hu
Accurate dose estimation under various inhalation conditions is important for assessing both the potential health effects of pollutant particles and the therapeutic efficacy of medicinal aerosols. We measured total deposition fraction (TDF) of monodisperse micrometer-sized particles [particle diameter (Dp) = 1, 3, and 5 μm in diameter] in healthy adults (8 men and 7 w...... hiện toàn bộ
Effects of pressure on uptake and release of calcium by brain synaptosomes
Journal of Applied Physiology - Tập 60 Số 4 - Trang 1446-1450 - 1986
Sara C. Gilman, K.K. Kumaroo, John M. Hallenbeck
Uptake of radioactive calcium from guinea pig brain fractions enriched in synaptosomes could be significantly and reproducibly decreased by exposure to high pressure. Calcium efflux from preloaded synaptosomes was unaffected by pressure exposure. It was hypothesized that the development of pressure-induced encephalopathy may be related to an effect of pressure on the central nervous syste...... hiện toàn bộ
M1/70 attenuates blood-borne neutrophil oxidants, activation, and myofiber damage following stretch injury
Journal of Applied Physiology - Tập 95 Số 3 - Trang 969-976 - 2003
Stacey Brickson, Lili Ji, Kathleen Schell, Ronke M. Olabisi, Barbara St. Pierre Schneider, Thomas M. Best
The purpose of this study was to determine the role of the CD11b-dependent respiratory burst in neutrophil oxidant generation and activation, interleukin-8 (IL-8) production, and myofiber damage after muscle stretch injury by using the monoclonal antibody M1/70 to block this pathway. Twelve male New Zealand White rabbits were randomly assigned to a treatment group: M1/70 ( n = 6), IgG isot...... hiện toàn bộ
Determination of oxygen consumption by use of the paramagnetic oxygen analyzer.
Journal of Applied Physiology - Tập 33 Số 2 - Trang 261-263 - 1972
Robert W. Hill
Metabolic and vasomotor insulative responses occurring on immersion in cold water
Journal of Applied Physiology - Tập 58 Số 3 - Trang 964-977 - 1985
L. Strong, Gin K. Gee, Ralph F. Goldman
Twenty male volunteers (17–28 yr of age) exhibiting a range of body weights (60 kg less than or equal to Wt less than or equal to 95 kg) and body fat (7% less than or equal to BF less than or equal to 23%) underwent total immersion while at rest in water between 36 and 20 degrees C. The metabolic heat production measured as a function of time and water temperature was converted to explici...... hiện toàn bộ
ACTN3 and MLCK genotype associations with exertional muscle damage
Journal of Applied Physiology - Tập 99 Số 2 - Trang 564-569 - 2005
Priscilla M. Clarkson, Eric P. Hoffman, Edward J. Zambraski, Heather Gordish‐Dressman, Amy K. Kearns, Monica J. Hubal, Brennan Harmon, Joseph M. Devaney
Strenuous exercise results in damage to skeletal muscle that is manifested in delayed muscle pain, prolonged strength loss, and increases in muscle proteins in the blood, especially creatine kinase (CK) and myoglobin (Mb). Some individuals experience profound changes in these variables in response to standard laboratory exercise or recreational activities. We proposed that variations in ge...... hiện toàn bộ
Surfactant-associated protein inhibits phospholipid secretion from type II cells
Journal of Applied Physiology - Tập 63 Số 2 - Trang 692-698 - 1987
Ward R. Rice, Gary F. Ross, Fannie M. Singleton, Sharon Dingle, J. A. Whitsett
Secretion of [3H]phosphatidylcholine ([3H]PC) from isolated rat pulmonary type II epithelial cells was inhibited by the surfactant-associated protein of Mr = 35,000 (SAP-35) purified from canine lung surfactant. SAP-35 inhibited [3H]PC secretion in a dose-dependent manner and significantly inhibited basal, phorbol ester, beta-adrenergic, and P2-purinergic agonist-induced [3H]PC secretion....... hiện toàn bộ
Blood O2 content measurements using the oxygen electrode
Journal of Applied Physiology - Tập 20 Số 5 - Trang 1063-1069 - 1965
Myron B. Laver, Anna Murphy, Astrid Seifen, Edward P. Radford
A method is described for determining the oxygen content in whole blood with the membrane-covered oxygen electrode that requires less time and skill than the Van Slyke-Neill technique. A blood sample (0.05 ml) is mixed with a large volume of dilute (0.2% w/v) potassium ferricyanide solution in equilibrium with ambient air and the oxygen tension of the mixture is measured at a known temper...... hiện toàn bộ
Mathematical analysis and digital simulation of the respiratory control system.
Journal of Applied Physiology - Tập 22 Số 2 - Trang 260-276 - 1967
Fred S. Grodins, Jennifer Buell, A J Bart
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