Journal of Analytical Science and Technology
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UPLC/FT-ICR MS-based high-resolution platform for determining the geographical origins of raw propolis samples
Journal of Analytical Science and Technology - Tập 10 - Trang 1-12 - 2019
In this study, we demonstrate a high-resolution 15 Tesla Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry coupled with a reverse-phase ultra-performance liquid chromatography (RP-UPLC) system for determining the geographical origins of raw propolis samples. The UPLC/FT-ICR MS-based high-resolution platform was validated on the ethanol-extracted propolis (EEP) from various propo......
Bioanalysis of alpelisib using liquid chromatography–tandem mass spectrometry and application to pharmacokinetic study
Journal of Analytical Science and Technology - Tập 13 - Trang 1-13 - 2022
Alpelisib is the first alpha-specific phosphatidylinositol-3-kinase (PI3K) inhibitor indicated for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative, PI3K catalytic subunit alpha-mutated, advanced, or metastatic breast cancer. Substantial attempts have been made to extend its clinical use to other types of cancer. Analytical methods proven to accurately ......
A rapid assessment method for determination of iodate in table salt samples
Journal of Analytical Science and Technology - Tập 4 - Trang 1-6 - 2013
In the present work, a simple and rapid method for determination of iodate is described. Iodometric reaction between iodate, excess iodide, and acid has been used, and the iodine liberated is allowed to react with variamine blue (VB) dye in the presence of sodium acetate to yield a violet-colored species. A calibration curve was obtained in the concentration range of 2 to 30 μg of iodate in a fina......
Environmentally preferable solvents promoted resolution of multi-component mixtures of amino acids: an approach to perform green chromatography
Journal of Analytical Science and Technology - Tập 4 - Trang 1-6 - 2013
Amino acids are the building blocks of proteins and found in structural tissues of the human body. Their deficiency may cause a number of diseases. Amino acids were analysed by the proposed thin layer chromatographic system using silica gel as stationary phase and Ethanol/70% aq. ethylene glycol/acetone (5:3:1) as mobile phase. Separations of some closely related amino acids from their quaternary,......
A novel cysteine catalytic oxidation-based colorimetric approach for sensitive analysis of acute pancreatitis-related microRNA
Journal of Analytical Science and Technology - Tập 14 - Trang 1-7 - 2023
It is essential to establish simple, sensitive and accurate quantitative approaches for microRNAs (miRNAs) identification due to its crucial roles in a variety of physiological and pathological processes. Herein, we propose a novel RCA-based colorimetric method for sensitive and reliable miRNA analysis. In this approach, cyclization of the padlock sequence by miRNA-21 initiates the RCA to produce ......
Accessible analytical methodology for assessing workplace contamination of antineoplastic drugs in limited-resource oncology health-care settings
Journal of Analytical Science and Technology - Tập 7 - Trang 1-9 - 2016
Environmental monitoring of workplaces where antineoplastic drugs are handled constitutes an essential tool to assess occupational exposures among health-care workers. Consequently, availability of simple, sensitive, and affordable analytical methodologies is needed, particularly in health-care settings with limited resources that restrict environmental monitoring studies. Previously validated met......
A sensitive chemiluminescence based immunoassay for the detection of cortisol and cortisone as stress biomarkers
Journal of Analytical Science and Technology - Tập 10 Số 1 - Trang 1-13 - 2019
An electrochemically based antibody immobilization was used to perform environmentally and clinically relevant immunoassays for stress hormones biomarkers (cortisol and cortisone) using chemiluminescence (CL) detection. To achieve CL detection, the ferrocene tag on the antibodies was first oxidised, and this then acted as a catalyst for the luminol and hydrogen peroxide CL reaction. The conditions......
Kinetic and Thermodynamic Spectrophotometric Technique to Estimate Gabapentin in Pharmaceutical Formulations using Ninhydrin
Journal of Analytical Science and Technology - Tập 4 - Trang 1-8 - 2013
Simple and sensitive spectrophotometric method is described based on the reaction of drug (gabapentin) with ninhydrin in pure form and in pharmaceutical preparations. Complex formed during this reaction is measured at 575 nm as a function of time. Kinetic study involve initial-rate, rate-constant and fixed-time (80 minutes) procedures to determine the concentration of the drug. Drug was studied in......
Identification, method development, validation, and characterization of Aza sugars by an ion-chromatography, high-resolution mass spectrometer, and LC-MS/MS
Journal of Analytical Science and Technology - Tập 9 - Trang 1-16 - 2018
Aza sugars are organi c sugars having nitrogen containing polyhydroxyl sugar molecules. These molecules are active pharmaceutical ingredients; these are not well separated and eluted early in the HPLC and UPLC columns due to high polar nature. Aza sugars are having high conductivity hence the ion chromatography validated method has been established for the castanospermin and celgosivir along with ......
Spectrophotometric determination and spectroscopic studies on Schiff base and charge transfer complex of ketorolac tromethamine
Journal of Analytical Science and Technology - Tập 6 Số 1 - 2015
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