UHPLC‐Q‐TOF‐MS/MS‐guided dereplication to study chemical constituents of Hedera nepalensis leaves in northern Vietnam
Tóm tắt
Hedera nepalensis is commonly used as a traditional medicine for the treatment of several diseases. In this research, the efficient characterization of chemical constituents, especially triterpenoid saponins, contained in H. nepalensis extract was established by applying ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry method (UHPLC‐Q‐TOF‐MS/MS). As a result, a total of 45 compounds including 21 triterpene saponins were tentatively elucidated based on MS and MS/MS data, in which eight structures have been reported for the first time. This study provided an efficient analysis strategy to rapidly determine the chemical constituents and laid a foundation for future study of H. nepalensis planted in Northern Vietnam and other Hedera species.
Tài liệu tham khảo
Ackerfield J, Wen J. A morphometric analysis of Hedera L. (the ivy genus, Araliaceae) and its taxonomic implications. Adansonia. 2002;24(2):197–212.
Bashir A, Nida M, Shumaila B, Sadiq A, Ibrar K, Mohammad A. Biological screening of Hedera nepalensis. J Med Plants Res. 2012;6(39):5250–7.
Chua SL, Mohd-Amin AN, Hong-Neo CJ, Lee HT, Lee TC, Sarmidi RM, Aziz AR. LC–MS/MS-based metabolites of Eurycoma longifolia (Tongkat Ali) in Malaysia (Perak and Pahang). J Chromatogr B. 2011;879:3909–19.
Er-Fei Z, Yun L, Zi Y, Qing Z. Identification and structural characterisation of triterpene saponins. Nat Prod Res. 2018;32(8):918–23.
Haruhisa K, Shingo K, Fukio N, Tsuyoshi T, Tsuneo N. Studies on nepalese crude drugs. III. On the Saponins of Hedera nepalensis K. Koch. Chem Pharm Bull. 1985;33(8):3324–9.
Huang C, Xu Q, Chen C, Song C, Yu Y, Xiang Y, Feng Y, Ouyang H, Zhang Y, Jiang H. The rapid discovery and identification of physalins in the calyx of Physalis alkekengi L.var.franchetii (Mast.) Makino using ultra-high performance liquid chromatography-quadrupole time of flight tandem mass spectrometry together with a novel three-step data mining strategy. J Chromatogr A. 2014;1361:139–52.
Kumaria S, Elancheran R, Kotoky J, Devi R. Rapid screening and identification of phenolic antioxidants in Hydrocotyle sibthorpioides Lam. by UPLC-ESI-MS/MS. Food Chem. 2016;203:521–9.
Leonid AY and Vladimir IG. Chapter 11: Ivy and licorice triterpene glycosides: promising molecular containers for some drugs and biomolecules. Studies in natural products chemistry. 2017;55:351–83.
Miao-miao J, Wen-dan Z, Hong-hong J, Ying-feng D, Wei G, Liang C, Hui-jun X. UPLC-Q-TOF-MS/MS-guided dereplication of Pulsatilla chinensis to identify triterpenoid saponins. Phytochem Anal. 2018;29(5):516–27.
Qi Y, Qingwang L, Cunyong H, Xiaohua M, Xiaoli G, Amer T, Jianping Z. UPLC-Q-TOF/MS characterization, HPLC fingerprint analysis and species differentiation for quality control of Nigella glandulifera Freyn et Sint seeds and Nigella sativa L. seeds. Anal Methods. 2014;6:4845–52.
Saleem S, Jafri L, Haq IU, Chang LC, Calderwood D, Green BD, Mirza B. Plants Fagonia cretica L. and Hedera nepalensis K. Koch contain natural compounds with potent dipeptidyl peptidase-4 (DPP-4) inhibitory activity. J Ethnopharmacol. 2014;156:26–32.
Samia I, Rukhsana I, Ateeq-ur R, Fayyaz MC, Bushra M. Biological evaluation of some selected plant species of Pakistan. Pharm Biol. 2007;45(5):397–403.
Samia I, Paul DP, Hassan KO, Ata-ur R, Bushra M. Bioprospecting traditional Pakistani medicinal plants for potent antioxidants. Food Chem. 2012;132(1):222–9.
Simab K, Nazif U, Ihsan UH, Imran A, Bushra M. Antioxidant, antitumor activities and phytochemical investigation of Hedera nepalensis K. Koch, an important medicinal plant from Pakistan. Pak J Bot. 2011;43:85–9.
Sun TT, Liang XL, Zhu HY, Peng XL, Guo XJ, Zhao LS. Rapid separation and identification of 31 major saponins in Shizhu ginseng by ultra-high performance liquid chromatography–electron spray ionization–MS/MS. J Ginseng Res. 2016;40(3):220–8.
Yue-Wei G, Shu Z, Kayo Y, Katsuko K. MS/MS similarity networking accelerated target profiling of triterpene saponins in Eleutherococcus senticosus leaves. Food Chem. 2017;227:444–52.