TIGIT in cancer immunotherapy Tập 8 Số 2 - Trang e000957 - 2020
Joë-Marc Chauvin, Hassane M. Zarour
Tumors evade immune-mediated recognition through multiple mechanisms of immune escape. On chronic tumor antigen exposure, T cells become dysfunctional/exhausted and upregulate various checkpoint inhibitory receptors (IRs) that limit T cells’ survival and function. During the last decade, immunotherapies targeting IRs such as programmed cell death receptor 1 (PD-1) and anticytotoxic T lymph...... hiện toàn bộ LAG-3: from molecular functions to clinical applications Tập 8 Số 2 - Trang e001014 - 2020
Takumi Maruhashi, Daisuke Sugiura, Il‐mi Okazaki, Taku Okazaki
To prevent the destruction of tissues owing to excessive and/or inappropriate immune responses, immune cells are under strict check by various regulatory mechanisms at multiple points. Inhibitory coreceptors, including programmed cell death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4), serve as critical checkpoints in restricting immune responses against self-tissues and tumor ce...... hiện toàn bộ Baseline neutrophil-to-lymphocyte ratio (NLR) and derived NLR could predict overall survival in patients with advanced melanoma treated with nivolumab - 2018
Mariaelena Capone, Diana Giannarelli, Domenico Mallardo, Gabriele Madonna, Lucia Festino, Antonio Grimaldi, Vito Vanella, Ester Simeone, Miriam Paone, Giuseppe Palmieri, Ernesta Cavalcanti, Corrado Caracò, Paolo A. Ascierto
Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity Tập 8 Số 2 - Trang e001369 - 2020
Iuliia Efimova, Elena Catanzaro, Louis Van der Meeren, Victoria D. Turubanova, Hamida Hammad, Tatiana A. Mishchenko, Maria V. Vedunova, Carmela Fimognari, Claus Bachert, Frauke Coppieters, Steve Lefever, André G. Skirtach, Olga Krysko, Dmitri V. Krysko
BackgroundImmunotherapy represents the future of clinical cancer treatment. The type of cancer cell death determines the antitumor immune response and thereby contributes to the efficacy of anticancer therapy and long-term survival of patients. Induction of immunogenic apoptosis or necroptosis in cancer cells does activate antitumor immunity, but resistan...... hiện toàn bộ